Emerging Roles of Fc Receptor-Like 1 in Immunotherapy of Diffuse Large B-Cell Lymphoma [0.03%]
Fc受体样蛋白1在弥漫性大B细胞淋巴瘤免疫治疗中作用机制的研究进展
Kayce Blumenstock,Vandana Zaman,Camille Green et al.
Kayce Blumenstock et al.
Fc Receptor-Like 1 (FCRL1), a member of the FCRL family, contains two immunoreceptor tyrosine-based activation motifs (ITAMs) in its cytoplasmic domain and plays a critical role in B-cell biology. Its expression begins in pre-B-cells, dynam...
The Yin-Yang of Stress and Senescence: Integrated Stress Response and SASP Crosstalk in Stem Cell Fate, Regeneration, and Disease [0.03%]
应激与衰老的阴阳关系：整合应激反应和分泌表型在干细胞命运、再生及疾病中的相互作用
Douglas M Ruden
Douglas M Ruden
Stem cell fate decisions are increasingly understood through the dynamic interplay of two fundamental stress-adaptive programs: the integrated stress response (ISR) and the senescence-associated secretory phenotype (SASP). These pathways ac...
Exploring Neutrophil Extracellular Traps in Cardiovascular Pathologies: The Impact of Lipid Profiles, PAD4, and Radiation [0.03%]
探究中性粒细胞胞外陷阱在心血管疾病中的作用：脂质谱系、PAD4和辐射的影响
Siarhei A Dabravolski,Michael I Bukrinsky,Aleksandra S Utkina et al.
Siarhei A Dabravolski et al.
Neutrophil extracellular traps (NET) have emerged as critical players in the pathogenesis of atherosclerosis and other cardiovascular diseases (CVD). These web-like structures, composed of DNA, histones, and granule proteins released by neu...
Eosinophils in Rheumatoid Arthritis: A Multifaceted Role in the Pathogenesis of the Disease [0.03%]
风湿性关节炎中嗜酸性粒细胞在疾病发病机制中的多重作用
Alexander Blagov,Michael Bukrinsky,Aleksandra Utkina et al.
Alexander Blagov et al.
Eosinophils are multifunctional granulocytes that contribute to the initiation and modulation of inflammation. Accumulating evidence suggests that eosinophils are adaptable leukocytes that orchestrate the resolution of inflammatory response...
Integrin Alpha8 Beta1 (81): An In-Depth Review of an Overlooked RGD-Binding Receptor [0.03%]
整合素α8β1（α8β1）：一个被忽视的RGD结合受体的深入综述
Iman Ezzat,Marisa Zallocchi
Iman Ezzat
Integrins are heterodimeric transmembrane receptors that mediate bidirectional interactions between the intracellular cytoskeletal array and the extracellular matrix. These interactions are critical in tissue development and function by reg...
Regulatory role of NFAT1 signaling in articular chondrocyte activities and osteoarthritis pathogenesis [0.03%]
NFAT1信号在关节软骨细胞活性和骨关节炎发病机制中的调控作用
Mingcai Zhang,Tanner Campbell,Spencer Falcon et al.
Mingcai Zhang et al.
Osteoarthritis (OA), the most common form of joint disease, is characterized clinically by joint pain, stiffness, and deformity. OA is now considered a whole joint disease; however, the breakdown of the articular cartilage remains the major...
Reversal of maternal obesity attenuates hypoxia and improves placental development in the preeclamptic-like BPH/5 mouse model [0.03%]
母体肥胖的逆转缓解子痫前期样小鼠模型BPH/5的胎盘发育不良及低氧状况
Daniella M Adams,Kalie F Beckers,Juliet P Flanagan et al.
Daniella M Adams et al.
Background: Women with obesity have higher risk of adverse pregnancy outcomes, including preeclampsia (PE). Late-gestational hypertension, aberrant fetoplacental development, and fetal growth restriction (FGR), hallmarks ...
Anti-proliferative effect of Annona extracts on breast cancer cells [0.03%]
annonaceae提取物的抗乳腺癌细胞增殖作用
Maria-Luisa Veisaga,Mariam Ahumada,Stacy Soriano et al.
Maria-Luisa Veisaga et al.
Backgorund: Fruits and seed extracts of Annona montana have significant cytotoxic potential in several cancer cells. This study evaluates the effect of A. montana leaves hexane extract on several signaling cascades and ge...
Effect of non-enzymatic glycation on collagen nanoscale mechanisms in diabetic and age-related bone fragility [0.03%]
非酶促糖基化对糖尿病和年龄相关骨质疏松症胶原纳米级机制的影响
James L Rosenberg,William Woolley,Ihsan Elnunu et al.
James L Rosenberg et al.
Age and diabetes have long been known to induce an oxidative reaction between glucose and collagen, leading to the accumulation of advanced glycation end-products (AGEs) cross-links in collagenous tissues. More recently, AGEs content has be...
Protein-mediated interactions in the dynamic regulation of acute inflammation [0.03%]
急性炎症动态调节中的蛋白质介导相互作用
Ryan Stark
Ryan Stark
Protein-mediated interactions are the fundamental mechanism through which cells regulate health and disease. These interactions require physical contact between proteins and their respective targets of interest. These targets include not on...