Diagnosis of Prion Diseases [0.03%]
朊毒症的诊断
Tayyaba Saleem,Anna-Lisa Fischer,Sezgi Canaslan et al.
Tayyaba Saleem et al.
Prion diseases are rapidly progressive and fatal neurodegenerative disorders caused by misfolded prion proteins. Accurate and early diagnosis is essential to distinguish these conditions from treatable dementias and to prevent iatrogenic tr...
Advancements in Chronic Wasting Disease (CWD) Prion Detection: Moving Beyond the Gold Standards [0.03%]
慢性消耗性疾病的朊病毒检测进展：超越金标准的方法
Paulina Soto,Reece McGinn,Rodrigo Morales
Paulina Soto
Chronic wasting disease (CWD) is perhaps the most problematic prion disease at present, considering its rapid spread in North America, its presence in both captive and wild animals, and its unknown zoonotic potential. Although several strat...
Dynamic Post-translational Modifications of Nuclear Lamins in Cellular Function and Pathophysiology [0.03%]
核纤层蛋白的动态翻译后修饰及其在细胞功能和病理生理学中的作用
Anjali Sharma,Nabanita Das,Rohini Bhatt et al.
Anjali Sharma et al.
Nuclear lamins, a crucial type of intermediate filament protein, primarily form the inner nuclear membrane and are essential for maintaining nuclear integrity throughout various cell cycle stages. However, recent research has uncovered thei...
The Fall of the Armor: Lamin Dysregulation and a Wide Network of Laminopathies [0.03%]
层层衰落：核纤层调控失常与多种核纤层病的关系
Hrishee Ray,Tapas K Kundu
Hrishee Ray
The nuclear membrane of cells harbors a lamina as a critical structural component beneath itself which serves as a dynamic scaffold that maintains nuclear integrity and cellular homeostasis. The primary component of the nuclear lamina is la...
Shuvadip Dutta,Mithun K Mitra
Shuvadip Dutta
Lamin proteins, predominantly located near the nuclear lamina, are known to play an important role in maintaining large-scale genome organisation. Disruptions in lamin assembly have been implicated in various diseases exhibiting altered chr...
The Strange Case of the Noncanonical Lamina: Deep Divisions in Nuclear Organisation? [0.03%]
非经典的核小体排列：核组织的深层分隔？
Mark C Field,Michael P Rout
Mark C Field
The nuclear envelope is subtended in most eukaryotes by a proteinaceous lamina, a network that has been recognised since the 1950s. Originally considered as a simple structural support, it is now clear that the lamina can be highly dynamic ...
Bipasa Mandal,Indrakshi Banerjee,Md Wasim Akram Ddoza Hazari et al.
Bipasa Mandal et al.
The extracellular matrix (ECM) and nuclear lamina are fundamental components of cellular architecture, playing pivotal roles in mechanotransduction and gene regulation. The dynamic interplay between the ECM and lamin proteins profoundly inf...
Changes in Chromatin Organisation and Mechanotransduction Mediated by Mutant Lamins in Laminopathies [0.03%]
染色体组织和层粘连蛋白opathy突变介导的机械转导的变化
Subhradip Nath,Kaushik Sengupta
Subhradip Nath
The filamentous nuclear lamina network is predominantly made up of lamin proteins, which play pivotal roles in maintaining nuclear architecture, chromatin structure, mechanotransduction and various other nuclear processes. Among the lamin p...
Differential Expression of Lamins and Modulation of Chromatin Architecture in Carcinogenesis: tous pour un et un pour tous [0.03%]
lamin蛋白的差异表达及在肿瘤发生过程中染色质结构的重塑：一人一表型，多者共机制
Shreyasi Dey Sarkar,Duhita Sengupta,Kaushik Sengupta
Shreyasi Dey Sarkar
Lamins are intermediate filament proteins of the nucleus that are present in nuclear lamina as well as nucleoplasm. They play diverse roles in maintaining the structure and rigidity of the nucleus as well as nuclear homeostasis. Lamins are ...
Genetics and cancer-related Laminopathies: Involvement of Lamins and Lamin-Chromatin Interactions [0.03%]
基因与癌症相关的Laminopathy：核纤层蛋白和核纤层蛋白-染色质相互作用的参与
Camille Desgrouas,Diane Frankel,Nathalie Bonello-Palot et al.
Camille Desgrouas et al.
Lamins are essential for maintaining the mechanical stability of the nucleus and organizing chromatin. B-type lamins are expressed early in embryogenesis, particularly in the central nervous system, where they are crucial for development. I...