The Many Lives of a Single Sequence: Functional Plasticity Through Amyloid Polymorphism [0.03%]
单一系列的多重生命：通过淀粉样多态性实现的功能可塑性
Mariana Pigozzi Cali,Jim Monistrol,Fabio Strati et al.
Mariana Pigozzi Cali et al.
Amyloids play critical functional roles in biology, including microbial virulence, innate immunity, and cellular organization, broadening their traditional association with neurodegenerative and systemic diseases. This chapter explores the ...
Abhinaba Das,Vincent Conticello
Abhinaba Das
Helix-helix interactions are mediated through highly designable interfaces within tertiary and quaternary structures of proteins and protein assemblies. The structural regularity of these interfaces suggests that ordered self-assembled stru...
Biology and Molecular Structure of the α-Fibrous Silks in Bees, Ants, Wasps and Hornets (Hymenoptera) [0.03%]
蜜蜂、蚁、黄蜂和胡蜂(Hymenoptera)的α-丝蛋白的生物学和分子结构研究
Caitlin Johnston,Lyndall Briggs,Michelle Michie et al.
Caitlin Johnston et al.
Larval aculeate insects (bees, ants and hornets) have evolved a silk for cocoon and nest construction based on entirely different design principles from the convergently evolved silk of spiders and silkworms. The silk is based on the coiled...
John W Weisel,Rustem I Litvinov
John W Weisel
Fibrin is a fibrous biopolymer that plays a crucial role in hemostasis, thrombosis, wound healing, and various other biological functions and pathological conditions. The X-ray crystallographic structure of fibrinogen, along with computatio...
Elizabeth G Canty-Laird,Himadri S Gupta,Helen L Birch
Elizabeth G Canty-Laird
The world population is ageing rapidly. The over-60s now outnumber the under- 5s, and 1 in 6 people will be over 60 by 2030 (WHO). Collagen is a key structural component of many tissues and organs, and although a fraction of the collagenous...
Andrzej Fertala
Andrzej Fertala
This chapter explores the role of fibrillar collagens, mainly collagen I, in developing fibrotic disorders associated with acute or chronic injuries. While collagen molecules' fundamental structure, composition, and intracellular biosynthes...
Collagen Mechanics [0.03%]
胶原蛋白力学
Phoebe Szarek,Jeffrey W Ruberti
Phoebe Szarek
The collagen superfamily has evolved over nearly a billion years to produce a set of at least 28 proteins that are present in all vertebrates. Of these, the fibrillar collagens (Types I-III, V, XI, XIV, and XVII) comprise a diverse, fibrous...
Comparative Study of the Positions of Glycosylated Residues in the Chains of Fibril-Forming Collagens and the Role that These Residues Play in Axial and Lateral Assembly [0.03%]
关于原纤维形成胶原链上糖基化残基位置的比较研究及其在轴向和侧向聚集中的作用
Gillian E Norris,David A D Parry
Gillian E Norris
In this review, we have collected and analysed collagen glycosylation data in an effort to better understand its possible function in fibrillogenesis. Towards that end, we have identified glycosylation sites in many different fibril-forming...
The Fibrillar Collagens of Bony Fish: Genes, Proteins, and Biomedical Applications [0.03%]
硬骨鱼类的纤维素基因、蛋白质及其生物医学应用
Ian P Smith,Jordi Bella
Ian P Smith
Fibrillar collagens are the most abundant structural proteins in vertebrates, forming the backbone of connective tissues such as skin, bone, tendon, and cartilage. In bony fish (teleosts), fibrillar collagens exhibit unique genetic and bioc...
Sarah Köster,Harald Herrmann
Sarah Köster
Intermediate filaments (IFs) possess unique mechanical properties that distinguish them from actin filaments and microtubules. In particular, they exhibit high flexibility, pronounced extensibility, and complete stability during biochemical...