Future Directions in Biotechnological and Pharmacological Applications of CAIs [0.03%]
赤霉素在生物技术及药学中的未来研究方向
Claudiu T Supuran,Neera Raghav
Claudiu T Supuran
Around 50 different chemotypes were described so far to possess carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action, through five different inhibition mechanisms: zinc coordination, anchoring to the zinc-coordinated water molecule; occlud...
Claudiu T Supuran,Rashmi Pundeer,Clemente Capasso
Claudiu T Supuran
Carbonic anhydrases (CAs) are highly efficient metalloenzymes catalyzing the reversible conversion of carbon dioxide (CO2) into bicarbonate (HCO3-) and protons (H+). Over the past decades, CAs have been employed across diverse industrial an...
Applications of Carbonic Anhydrase Inhibitors in Arthritis, Neuropathic Pain, Acute Mountain Sickness, and Cerebral Ischemia [0.03%]
碳酸酐酶抑制剂在关节炎、神经痛、急性高山病和脑缺血中的应用
Alessio Nocentini,Rashmi Pundeer,Claudiu T Supuran
Alessio Nocentini
Carbonic anhydrase inhibitors (CAIs) have long been used as diuretics, topically acting antiglaucoma agents, anticonvulsants, and for the treatment of altitude sickness. Lately, they have shown promising results as anti-obesity, antimicrobi...
Applications of Carbonic Anhydrase Inhibitors in Neurological Disorders, Mechanisms and Therapeutic Potential [0.03%]
碳酸酐酶抑制剂在神经系统疾病中的应用、机制和治疗潜力
Neera Raghav,Rashmi Pundeer
Neera Raghav
Eleven carbonic anhydrase isoforms are known to be present in different parts of the central nervous system and are involved in signal transduction, cerebral fluid homeostasis, bicarbonate generation, respiratory response to carbon dioxide,...
Claudiu T Supuran,Andrea Angeli
Claudiu T Supuran
Tumor hypoxia and extracellular acidosis are hallmarks of the tumor microenvironment that promote cancer progression, metabolic adaptation, and resistance to therapy. Among the molecular mediators of these processes, carbonic anhydrase IX (...
Simone Giovannuzzi,Alessio Nocentini,Claudiu T Supuran
Simone Giovannuzzi
Ophthalmology is the branch of medicine devoted to the study, diagnosis, and treatment of disorders affecting the eye and visual system, as glaucoma is. It is a leading cause of irreversible blindness worldwide and is commonly diagnosed sol...
Alessandro Bonardi,Paola Gratteri
Alessandro Bonardi
Human carbonic anhydrases (hCAs) are emerging as increasingly relevant therapeutic targets due to their involvement in a broad spectrum of pathological conditions, ranging from glaucoma and epilepsy to cancer, neuroinflammation, metabolic d...
Neera Raghav,Niccolò Paoletti,Claudiu T Supuran
Neera Raghav
Carbonic anhydrases (CAs) are ubiquitous zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide and play essential roles in numerous physiological and pathological processes. Over the past decades, carbonic anhydrase i...
Neera Raghav,Claudiu T Supuran,Alessio Nocentini
Neera Raghav
The catalytic mechanism of carbonic anhydrase (CA, EC 4.2.1.1) at least for the physiological CO2 hydration is well understood, with the CO2-bicarbonate interconversion due to the nucleophilic attack of a zinc hydroxide species on the subst...
Clemente Capasso,Claudiu T Supuran
Clemente Capasso
Carbonic anhydrases (CAs) form a widely distributed superfamily of metalloenzymes, characterized by considerable structural diversity. These enzymes catalyze the reversible conversion of carbon dioxide into bicarbonate and protons. While th...