Miguel Ruiz,Savannah M Bogus,Andreas M Ernst
Miguel Ruiz
Biomolecular condensates represent a new paradigm of cytoplasmic organization. In recent years, an increasing amount of evidence suggests that protein condensates can directly impact the morphology and function of membrane compartments. The...
Models of Intracellular Transport: Contradictions and Current Understanding [0.03%]
细胞内运输模型：矛盾和当前的理解
Alexander A Mironov,Galina V Beznoussenko
Alexander A Mironov
Intracellular transport is one of the most complex and debated topics in cell biology. Numerous models and their combinations have been proposed to explain experimental data on this process. This article describes our current understanding ...
Alexandre Varangot,Cyril Hanus
Alexandre Varangot
Like other cells, neurons synthesize, chemically modify, and traffic secreted and surface membrane proteins in the specialized biosynthetic membrane network of the secretory pathway. Unlike other cells, neurons develop and maintain very lon...
The Impact of Golgi Organization on Cell Cycle and Cancer Development [0.03%]
戈尔吉体的组织结构对细胞周期和癌症发展的影响
Antonino Colanzi,Inmaculada Ayala
Antonino Colanzi
The Golgi complex plays a pivotal role in the secretory pathway, cell signaling, and cytoskeleton organization. In mammalian cells, it is organized as a ribbon-like structure that can undergo dynamic reorganizations, which are crucial for v...
Association of Golgi Stacks and Recycling Endosomes Ensures Post-Golgi Trafficking [0.03%]
高尔基体堆和回肠内体的结合确保了后高尔基体转运
Akiko K Satoh
Akiko K Satoh
The trans-Golgi network (TGN) has traditionally been considered the primary sorting hub for newly synthesized proteins, whereas recycling endosomes (REs) are recognized as intermediate stations for endocytosed materials before their return ...
Jaakko Saraste,Kristian Prydz
Jaakko Saraste
In addition to the classical secretory pathway, which involves the transport of endoplasmic reticulum (ER)-derived cargo through the cisternal stacks of the Golgi apparatus, several Golgi-independent transport routes contribute to the deliv...
Revealing Golgi Architecture: Novel Insights Through Light Microscopy [0.03%]
高尔基体的结构解析——透过光学显微镜技术获得的新认识
Divyanshu Mahajan,Lei Lu
Divyanshu Mahajan
The Golgi is a eukaryotic organelle that modifies, sorts, and transports proteins and lipids to their destinations. In mammals, the Golgi is a complex network of interconnected stacks, with each stack made up of closely packed flat membrane...
Akihiro Harada
Akihiro Harada
Using super-resolution microscopies, SCLIM and STORM, and CRISPR/Cas9 knockin technology, we show that the Golgi complex is assembled by a number of small "Golgi units" that are 1-3 μm in diameter. Each Golgi unit can be considered a funct...
Three-Dimensional Ultrastructure of the Golgi Apparatus In Vivo: Scanning Electron Microscopy of Osmium-Macerated Mammalian Cells [0.03%]
高尔基体的三维 ultrastructure：锇消化的哺乳动物细胞的扫描电子显微镜观测结果
Daisuke Koga,Ryosuke Morinaga,Satoshi Kusumi
Daisuke Koga
The osmium maceration method remains the only technique that enables direct three-dimensional (3D) visualization of subcellular structures via scanning electron microscopy (SEM), and it is particularly effective for resolving spatially comp...
Seed Amplification Assays as Powerful Tools for Detecting Peripheral Biomarkers in Prion-Like Diseases [0.03%]
用于检测朊病毒样疾病外周生物标志物的种子放大实验作为一种强有力的工具
Ilaria Linda Dellarole,Annalisa Lombardo,Arianna Ciullini et al.
Ilaria Linda Dellarole et al.
Seed amplification assays (SAAs) are highly sensitive and advanced techniques originally developed for the study and diagnosis of prion diseases. Thanks to their remarkably high sensitivity and specificity, SAAs are now widely employed in b...