Noncoding RNAs: A Novel Frontier in Liver Cancer Research and Therapy: Implications for Precision Oncology [0.03%]
非编码RNA：肝癌研究和治疗的新前沿：精准肿瘤学的意义
Al-Aliaa M Sallam,Mahmoud A Elrebehy,Ibrahim M Elazab et al.
Al-Aliaa M Sallam et al.
There is an urgent need for reliable noninvasive indicators of the occurrence and course of liver disease. According to research conducted in recent decades, the risk scores for liver-related complications can be determined by utilizing the...
Unlocking the Epigenetic Landscape of Colorectal Cancer: A Step Toward Epigenetics to Precision [0.03%]
解锁结直肠癌表观遗传景观：迈向精确医学的一小步
Maha M Elbrashy,Sally Farouk,Nadia M Hamdy et al.
Maha M Elbrashy et al.
Epigenetic modifications function as central controllers of gene expression in cancer, coordinating crucial cellular activities that trigger the initiation and progression of the tumor, besides their importance in therapeutic response. Thes...
Mapping Non-Coding Epimutations in Breast Cancer: Advancing Epigenetics Towards Precision Medicine [0.03%]
绘制乳腺癌表观遗传变异图谱：推进精准医学的表观遗传学研究
Mohamed E Abdel Aziz,Heba Momtaz,Basel Mohamed et al.
Mohamed E Abdel Aziz et al.
Breast cancer remains a leading cause of cancer-related morbidity and mortality in women worldwide. While extensive research has focused on mutations in protein-coding genes, emerging evidence underscores the pivotal role of the noncoding g...
The Intricate Interplay of Noncoding RNAs and the Gut Microbiome in Gastrointestinal and Endocrine-Related Cancers [0.03%]
非编码RNA和肠道微生物组在胃肠和内分泌相关癌症中的相互作用
Sherien M El-Daly,Bahgat Fayed,Roba M Talaat et al.
Sherien M El-Daly et al.
The human gut microbiome and noncoding RNAs (ncRNAs) represent interconnected regulatory networks that profoundly influence cancer development, particularly in gastrointestinal and endocrine-related malignancies. This chapter delineates the...
Epigenetic Modulation of Immunity: Mechanisms, Implications, and Emerging Therapeutic Horizons; a Step Toward Epigenetics to Precision [0.03%]
表观遗传调控免疫：机制、意义及新兴治疗前景；从表观遗传学到精准医学的一小步
Dalia O Saleh,Mohamed L Salem,Sophie Van Linthout et al.
Dalia O Saleh et al.
Epigenetic regulation plays a central role in immune cell development, specialization, and memory formation by dynamically modifying DNA, histones, and RNA. These processes enable adaptation to environmental cues, precise pathogen responses...
Junko Toshima,Jiro Toshima
Junko Toshima
Endocytosis is the process by which cells internalize extracellular materials, cell surface proteins, and lipids via vesicles formed by membrane invagination. Endocytosed cargos are first delivered to sorting compartments and then recycled ...
Benjamin S Glick
Benjamin S Glick
The budding yeast Saccharomyces cerevisiae is tremendously useful for revealing basic principles of cell biology. An example is the characterization of the endomembrane system, which consists of secretory, endocytic, and autophagic compartm...
Takuro Tojima,Akihiko Nakano
Takuro Tojima
The Golgi apparatus in the budding yeast Saccharomyces cerevisiae, unlike those in mammalian and plant cells, does not form stacks but exists as multiple separate cisternae scattered throughout the cytoplasm. This unique morphological featu...
Elizabeth Berryman,Ariadna González Solís,Ethan Weiner et al.
Elizabeth Berryman et al.
Post-Golgi trafficking in plants regulates transport to and from the cell surface, vacuolar trafficking, and recycling pathways within the endomembrane system. Endosomes serve as central hubs in these pathways, managing the composition of l...
Yoko Ito,Tomohiro Uemura
Yoko Ito
In spite of its highly conserved molecular constituents, the Golgi apparatus shows diverse morphologies depending on the organism and cell type. In particular, in plant cells, the distribution and dynamics of the Golgi differ considerably f...