Sarah Köster,Harald Herrmann
Sarah Köster
Intermediate filaments (IFs) possess unique mechanical properties that distinguish them from actin filaments and microtubules. In particular, they exhibit high flexibility, pronounced extensibility, and complete stability during biochemical...
Matthias Eibauer,Ohad Medalia
Matthias Eibauer
Intermediate filaments (IFs) are central to the mechanical integrity of metazoan cells and play critical roles in various fundamental cellular and multicellular processes, including cell motility, signal transduction, and wound healing. To ...
Structural and Functional Elements of the Epidermal Appendages in Birds and Reptiles: Conformations and Modes of Assembly of the Constituent β-Filaments and Keratin Intermediate Filaments (IF) [0.03%]
鸟类和爬行类表皮附属物的结构与功能要素：构成性β-丝和角蛋白中间丝(IF)的构型及装配方式
David A D Parry
David A D Parry
Much is now known about the structures of the β-filaments and the intermediate filaments that together constitute the bulk of the avian and reptilian (sauropsid) appendages (claws, scales, feathers and beaks). New sequence data from the Rh...
Structural Biology of Actin: Interplay Between Molecular Assembly, Conformational Polymorphism and ATPase [0.03%]
肌动蛋白结构生物学：分子装配、构象多形性和ATP酶之间的相互作用
Yuichiro Maéda,Toshiro Oda,Akihiro Narita et al.
Yuichiro Maéda et al.
Actin was first identified as a major muscle protein with two key activities: polymerization and ATPase. Although the significance of these activities in muscle contraction was unclear, subsequent cell biological studies revealed that actin...
The Structural Role of Tropomyosin in Regulating Thin Filament Activation of Actin-Myosin Interaction [0.03%]
肌钙蛋白调节薄丝活化作用中肌动蛋白-肌浆球蛋白相互作用的结构作用机制研究
William Lehman
William Lehman
Myosin motor-heads projecting from muscle thick filaments interact cyclically with actin-based thin filament tracks, thereby driving inter-filament sliding that powers muscle contraction. Here, controlled recruitment of myosin heads from th...
Pradeep K Luther
Pradeep K Luther
Striated muscle is composed of overlapping arrays of thick myosin filaments and thin actin filaments. The thick filaments are composed of myosin molecules, which are hexamers of two heavy chains and two pairs of light chains. The heavy chai...
Sequence Prediction, Structural Modelling and the Challenges of Plasticity in Coiled Coils [0.03%]
肽链卷曲螺旋的序列预测、结构建模及其可塑性的挑战
Christopher W Wood,Guto G Rhys,Evangelia Notari
Christopher W Wood
The coiled coil is one of the most widespread and versatile protein folding motifs and is involved in a vast array of biological functions. The study and design of these assemblies have been shaped by the development of specialised computat...
An Overview of Targeting Some Cancer Hallmarks with Plant Polyphenols: A Step Toward Precision [0.03%]
植物多酚针对某些癌症标志物的治疗作用概论：迈向精准医疗的第一步
Nadia M Hamdy,Amr Amin,Gamal Eldein Fathy Abd-Ellatef et al.
Nadia M Hamdy et al.
Polyphenols (PPs) are secondary metabolites that are present in more than 80% of plants. They possess a plethora of medicinal properties by modulating key pathological pathways, including epigenetics and those involved in oncogenesis or tum...
A Comprehensive Guide on Epigenetics' Precision Role in Uncommon "Rare" Cancers' Biology and Treatment Frontiers [0.03%]
表观遗传学在罕见癌症生物学和治疗前沿的精准作用的全面指南
Nadia M Hamdy,Ahmed S Doghish,Nehal I Rizk et al.
Nadia M Hamdy et al.
The significance of epigenetics and precision medicine in the context of uncommon cancers, referred to as "rare cancers," is investigated in this chapter.A comprehensive review of the current literature on noncoding RNAs (ncRNAs), natural p...
The Epigenetic Angle in the Precision Medicine Era for Blood Disorder Advancements [0.03%]
精确诊断时代的表观遗传学视角在血液科疾病诊疗中的应用与发展研究进展
Nadia M Hamdy,Ahmed I Abulsoud,Nehal I Rizk et al.
Nadia M Hamdy et al.
This work examined the integration of epigenetics and precision medicine in the management of various blood disorders, including anemias, antiphospholipid syndrome, hemochromatosis, hemophilia, leukemia, lymphoma, multiple myeloma, porphyri...