Regulation of Glycan Modification by Glycosyltransferases in the Golgi Apparatus [0.03%]
高尔基体中糖基转移酶介导的糖链修饰调控机制研究进展
Hirokazu Yagi,Seigo Tateo,Koichi Kato
Hirokazu Yagi
Protein glycosylation, a fundamental modification critical for diverse biological functions, is well orchestrated within the Golgi apparatus, a central organelle in the secretory pathway. This review explores the mechanisms by which the Gol...
Siamese Twins: The Multimodular Mechanisms of Golgi Maturation and Glycan Synthesis Are Coupled at Their Core [0.03%]
联体婴儿：高尔基体成熟和聚糖合成的核心耦合多模块机制
Domenico Russo,Seetharaman Parashuraman,Alberto Luini
Domenico Russo
The Golgi apparatus functions as the central processing hub for proteins and lipids, orchestrating glycosylation, sorting, and secretion. Once viewed as a passive site of bulk enzyme recycling, the Golgi is now recognized as a highly dynami...
Yutaro Shimizu,Tomohiro Uemura
Yutaro Shimizu
Membrane trafficking is crucial for various aspects of plant growth, development, and responses to environmental stimuli. The trans-Golgi network (TGN) in plants serves as a central sorting station for membrane trafficking and operates at t...
Jan Parolek,Yeongho Kim,Christopher G Burd
Jan Parolek
In organelle biogenesis pathways, the Golgi apparatus plays a central role in synthesizing and distributing complex sphingolipids, glycerolipids, and cholesterol, which form the membranes of organelles. The concept of 'lipid flow' describes...
Farhana Taher Sumya,Vladimir V Lupashin
Farhana Taher Sumya
The Conserved Oligomeric Golgi (COG) complex, an evolutionary conserved octameric vesicular tether, is essential for maintaining Golgi function by ensuring accurate delivery of resident proteins to their specific locations. Mutations in hum...
Amrita Khakurel,Walter S Aragon-Ramirez,Vladimir V Lupashin
Amrita Khakurel
The Golgi Associated Retrograde Protein (GARP) complex, a member of the Complexes Associated with Tethering Containing Helical Rods (CATCHR) family, is proposed to tether vesicles arriving from endosomes to the trans-Golgi network (TGN). Di...
Petia Adarska,Luis Wong-Dilworth,Francesca Bottanelli
Petia Adarska
ADP-ribosylation factors (ARFs) are small (~21 kDa) GTPases that play a central role in intracellular transport across eukaryotic cells. Structurally related to Ras GTPases, ARFs were initially discovered as allosteric activators of cholera...
Maraym Arab,Martin Lowe
Maraym Arab
The golgins are a family of ubiquitously expressed and evolutionary conserved Golgi-localised coiled-coil proteins. The golgins are particularly important for vesicle trafficking and structural organisation of the Golgi apparatus. The golgi...
Bruno Goud
Bruno Goud
The RAB family in humans comprises approximately 70 members with about one third localizing to the Golgi apparatus and associated compartments. This significant localization reflects the number and diversity of transport pathways operating ...
Kunyou Park,Jia-Shu Yang,Victor W Hsu et al.
Kunyou Park et al.
The Coat Protein I (COPI) complex forms both vesicles and tubules for transport at the Golgi complex. Anterograde Golgi transport occurs with the Golgi cisternae acting as carriers, a process known as cisternal maturation, while COPI vesicl...