Vitamin C in sepsis [0.03%]
维生素C在脓毒症中的应用
John X Wilson,F Wu
John X Wilson
Bacterial bloodstream infection causes septic syndromes that range from systemic inflammatory response syndrome (SIRS) and encephalopathy to severe sepsis and septic shock. Microvascular dysfunction, comprising impaired capillary blood flow...
Mario C De Tullio
Mario C De Tullio
When considering the history of vitamin C, and the names given to this molecule in early days, the Latin proverb nomen est omen suddenly comes to mind. Around 1920, when Casimir Funk introduced the term Vitamin C to indicate the nutritional...
Elaine L Jacobson,H Kim,M Kim et al.
Elaine L Jacobson et al.
Niacin is defined collectively as nicotinamide and nicotinic acid, both of which fulfill the vitamin functions of niacin carried out by the bioactive forms NAD(P). In the last few decades numerous new enzymes that consume NAD(P) as substrat...
Niacin status and genomic instability in bone marrow cells; mechanisms favoring the progression of leukemogenesis [0.03%]
烟酸状况与骨髓细胞基因组不稳定；有利于白血病发生的机制
James B Kirkland
James B Kirkland
Niacin deficiency causes dramatic genomic instability in bone marrow cells in an in vivo rat model. The end result is seen in the increased incidence of sister chromatid exchanges, micronuclei, chromosomal aberrations and the eventual devel...
Hamid M Said
Hamid M Said
Significant progress has been made in our understanding of the biochemical, physiological and nutritional aspects of the water-soluble vitamin biotin (vitamin H). It is well know now that biotin plays important roles in a variety of critica...
David Amberg,Jane E Leadsham,Vasillios Kotiadis et al.
David Amberg et al.
For some time the view that the actin cytoskeleton acts primarily as a scaffold, to be assembled in response to a signaling cascade as an end point in the pathway, has prevailed. However, it is now clear that the dynamic nature of the cytos...
Armin Rashidi,Thomas B L Kirkwood,Daryl P Shanley
Armin Rashidi
Mother cell-specific ageing is a well-known phenomenon in budding yeast Saccharomyces cerevisiae. Asymmetric segregation of damage and its accumulation in the mother cell has been proposed as one important mechanism. There are, however, uni...
Genetic approaches to aging in budding and fission yeasts: new connections and new opportunities [0.03%]
芽殖和裂殖酵母的遗传老化研究：新的联系与机会
Bo-Ruei Chen,Kurt W Runge
Bo-Ruei Chen
Yeasts are powerful model systems to examine the evolutionarily conserved aspects of eukaryotic aging because they maintain many of the same core cellular signaling pathways and essential organelles as human cells. We constructed a strain o...
George L Sutphin,Brady A Olsen,Brian K Kennedy et al.
George L Sutphin et al.
In the past several decades the budding yeast Saccharomyces cerevisiae has emerged as a prominent model for aging research. The creation of a single-gene deletion collection covering the majority of open reading frames in the yeast genome a...
Christian Q Scheckhuber,Andrea Hamann,Diana Brust et al.
Christian Q Scheckhuber et al.
Cellular quality control pathways are needed for maintaining the biological function of organisms. If these pathways become compromised, the results are usually highly detrimental. Functional impairments of cell components can lead to disea...