Tubular Lamin- and Emerin-Lined Nuclear Envelope Invaginations Isolate Chromatin Domains for Gene Expression Regulation [0.03%]
管状的染色质结构域隔间隔区用于基因表达调控
Qing Qin Ji,Zewen Ding,Jingxian Duan et al.
Qing Qin Ji et al.
Lamins provide physical support to the nucleus and maintain nuclear shape. In many disease states linked to lamin and other nuclear envelope (NE) protein mutations, altered nuclear shape is viewed as a reflection of aberrant lamin and nucle...
Role of Nuclear Envelope Proteins in the Structure and Function of the Neuromuscular Junction: Focus on Subsynaptic Nuclei [0.03%]
核被膜蛋白在神经肌肉突触结构和功能中的作用：亚突触细胞核为重点
Céline Douarre,Bruno Cadot,Antoine Muchir et al.
Céline Douarre et al.
The role of the nuclear envelope (NE) in skeletal muscle function was first recognized 30 years ago when mutations in NE-associated genes, such as SUN-1, Syne1, Syne2, and LMNA, were linked to muscular dystrophies, also known as nuclear env...
Role of Nuclear Lamins in the Regulation of the Genome: Focus on CardioLaminopathy [0.03%]
核纤层调控基因组的作用：着重于心血管疾病中的核纤层病
Marie Kervella,Antoine Muchir
Marie Kervella
Nuclear lamins, the unique type 5 intermediate filaments of the nucleus, form a structural network beneath the nuclear envelope. Through their strategic localization, they interact with numerous partners and regulate a wide range of biochem...
The Hidden Influences of Macromolecular Crowding: A New Frontier in Cellular Biology and Medicine [0.03%]
大分子拥挤的隐性影响：细胞生物学和医学的新前沿
Isabella V Gimón,Conner Sandefur,Santiago Schnell
Isabella V Gimón
Macromolecular crowding, the dense packing of macromolecules within cells, significantly influences enzyme kinetics, cell signaling, liquid-liquid phase separation, and disease progression. This review explores the multifaceted effects of c...
Shrawan Kumar Choudhary,Sangeeta,Pinki Dey et al.
Shrawan Kumar Choudhary et al.
The interaction between proteins and DNA is fundamental to numerous enzymatic processes, relying on the precise recognition of specific DNA bases by DNA-binding proteins (DBPs). This interaction occurs within the densely packed environment ...
Orkid Coskuner-Weber,Mert Koca,Vladimir N Uversky
Orkid Coskuner-Weber
Molecular crowding plays a crucial role in biological and medicinal systems, impacting the structure, behavior, and function of biomolecules within the densely packed environments of cells. This chapter provides an overview of the implicati...
Piero Andrea Temussi,Matteo Levantino
Piero Andrea Temussi
A few decades ago, it became clear that most biophysical studies were performed on proteins under conditions not corresponding to those found in vivo, thus limiting the generality of at least some of the conclusions. The main difference was...
Macromolecular Crowding for Reparative Medicine and Drug Discovery Applications [0.03%]
高分子拥挤技术在再生医学与新药研发中的应用
Giulia Giuffredi,Andrea Rossoni,Laura Trujillo Cubillo et al.
Giulia Giuffredi et al.
Cell-based reparative medicine and drug discovery utilise the innate sophistication of cells to build supramolecular assemblies. Unfortunately, bereft of their optimal tissue context, during in vitro culture, this ability is compromised. He...
Altijana Hromić-Jahjefendić,Vladimir N Uversky,Hana Krnjić
Altijana Hromić-Jahjefendić
Macromolecular crowding has significant impact on protein behavior in cellular environments, having influence on their structure, folding, and interactions. This process comes from the high concentration of macromolecules, including protein...
Crowding in Anhydrobiosis [0.03%]
干生作用中的拥挤效应
Alex Haydon,Charles A Elder,Rafael S Demarco et al.
Alex Haydon et al.
Anhydrobiosis, the exceptional adaptation of some organisms to enter a state approaching suspended animation after losing most cellular water, has fascinated scientists and non-scientists since Anthony van Leeuwenhoek described the phenomen...