Reshuffling Overcrowded Milieu: Stress-Induced Reorganization of the Eukaryotic Membrane-Less Organelles [0.03%]
拥挤环境下的重新洗牌：压力诱导下无膜细胞器的组织重塑
Anastasia A Gavrilova,Eva A Shmidt,Vladimir N Uversky et al.
Anastasia A Gavrilova et al.
Cells are crowded entities, but the intracellular space represents an inhomogeneously crowded environment, where the concentrations of macromolecules (proteins, nucleic acids, etc.) are not uniformly distributed throughout the cell resultin...
Mitsuki Tsuruta,Sumit Shil,Keiko Kawauchi et al.
Mitsuki Tsuruta et al.
The inside of a living cell is highly crowded with extremely diverse biomacromolecules, small metabolites and osmolytes. The molecular conditions in cells change dynamically and rapidly depending on the cell cycle and state, organelle, and ...
Michael A Model
Michael A Model
To study macromolecular crowding (MC) in living cells, one needs a method to measure it. Several existing approaches to quantify MC address slightly different aspects of crowding. If we define MC through protein concentration, it can be mea...
Munishwar Nath Gupta,Vladimir N Uversky
Munishwar Nath Gupta
Bacterial microcompartments (BMCs) and biomolecular condensates are two different forms of protein compartmentalization with different aims and functional advantages, representing specific designs of sequestering enzymes or segments of meta...
Masahiro Kumeta
Masahiro Kumeta
Nuclear pores serve as the sole gates mediating nucleocytoplasmic molecular communication. They constantly accept heavy molecular traffic at a rate of ~1000 molecules per second, selected from a vast number of molecules randomly approaching...
Semen V Nesterov,Vladimir N Uversky
Semen V Nesterov
The chapter reviews the various effects of crowding on mitochondrial structure and function. Data illustrate that, as a rule, the concentration of macromolecules in the mitochondrial matrix and inner membrane is at least as high as in other...
Muhamed Adilović,Vladimir N Uversky,Jasmin Šutković
Muhamed Adilović
A high concentration of diverse macromolecules causes a densely packed environment, influencing both function and structural change of the cell organelles, cytoplasm, and molecules within. The concept of molecular crowding was for the first...
Judith Herzfeld
Judith Herzfeld
The cytoskeleton is not only responsible for cell morphology and rheology, but is also involved in such functions as cell motility, intracellular transport and cell division. Key to all these roles is the suitable deployment of its labile p...
Understanding the Effect of Macromolecular Crowding on Protein Misfolding and Aggregation [0.03%]
理解大分子拥挤对蛋白质错误折叠和聚集的影响
Aabgeena Naeem,Gufran Ahmed Siddiqui
Aabgeena Naeem
Biological molecules evolved and function within cellular environments that are extremely congested by the presence of other macromolecules. A characteristic of the intracellular environment is that it contains the high concentration of mac...
Effects of Molecular Crowding on the Structure, Folding, Stability, and Catalysis of RNA [0.03%]
分子拥挤对RNA结构、折叠、稳定性和催化的的影响
Shu-Ichi Nakano
Shu-Ichi Nakano
Dynamic and thermodynamic properties of RNA molecules vary across different cellular locations through multiple environmental factors, such as excluded volume interactions of cellular substances, alteration of the physical properties of the...