The roles of AMPK/mTOR autophagy pathway in the acute kidney injury-induced acute lung injury [0.03%]
AMPK/mTOR自噬途径在急性肾损伤诱导的急性肺损伤中的作用
Si-Heng Shen,Ruo-Lin Wang,Qi Yuan et al.
Si-Heng Shen et al.
Acute kidney injury (AKI) is one of the most challenging clinical problems in kidney disease due to serious complications and high mortality rate, which can lead to acute lung injury (ALI) through inflammatory reactions and oxidative stress...
Comparisons of stress-related neuronal activation induced by restraint in adult male rat offspring with prenatal exposure to buprenorphine, methadone, or morphine [0.03%]
布洛芬、美沙酮和吗啡麻醉对大鼠胎儿产前神经元激活的比较研究
Chia-Yen Wu,Hwei-Hsien Chen,Pao-Luh Tao et al.
Chia-Yen Wu et al.
Prenatal opioid exposure may impede the development of adaptive responses to environmental stimuli by altering the stress-sensitive brain circuitry located at the paraventricular nucleus of the hypothalamus (PVH) and locus coeruleus (LC). C...
Mechanotransduction of mesenchymal stem cells and hemodynamic implications [0.03%]
有关间充质干细胞力学生物学及血流动力学意义的研究
Ting-Wei Kao,Yi-Shiuan Liu,Chih-Yu Yang et al.
Ting-Wei Kao et al.
Mesenchymal stem cells (MSCs) possess the capacity for self-renewal and multipotency. The traditional approach to manipulating MSC's fate choice predominantly relies on biochemical stimulation. Accumulating evidence also suggests the role o...
MiR-598-5p inhibits breast cancer tumor growth and lung metastasis by targeting PPAPDC1A [0.03%]
微RNA-598-5p通过靶向PPAPDC1A抑制乳腺癌肿瘤生长和肺转移
Xinyi Guo,Fan Yang,Liangfei Yu et al.
Xinyi Guo et al.
This study aimed to explore the effects of PPAPDC1A on the malignant phenotype of breast cancer (BC) in vivo and in vitro. PPAPDC1A expression was examined in BC tissues and cell lines by real-time polymerase chain reaction and Western blot...
High expression of BHLHE40 promotes immune infiltration and tumor progression in thyroid cancer [0.03%]
BHLHE40高表达促进甲状腺癌的免疫浸润和肿瘤进展
Qilin Gong,Huaying Li
Qilin Gong
Thyroid cancer (THCA) is a common malignancy of the endocrine system which threatens people's health and life quality. It is urgent to find the marker gene of THCA. BHLHE40 is a key gene involved in tumor malignant progression. However, the...
MiR-141-3p promotes malignant progression in prostate cancer through AlkB homolog 5-mediated m6A modification of protein arginine methyltransferase 6 [0.03%]
MiR-141-3p通过Alkbh5介导的蛋白质精氨酸甲基转移酶6的m6A修饰在前列腺癌中促进恶性进展
Xun Li,Bide Liu,Shuheng Wang et al.
Xun Li et al.
Prostate cancer (PCa) is one of the leading causes of cancer-related death in males worldwide and exploring more reliable biomarkers for PCa is essential for the diagnosis and therapeutics for the disease. Although the functions of miR-141-...
Tripartite motif 72 inhibits apoptosis and mitochondrial dysfunction in neural stem cells induced by anesthetic sevoflurane by activating PI3K/AKT pathway [0.03%]
三聚体 motif 72通过激活PI3K/AKT信号通路抑制神经干细胞中麻醉剂七氟醚诱导的凋亡和线粒体功能障碍
Minmin Cai,Xiang Gao,Shenghui Yu
Minmin Cai
Anesthetics exposure induces neurocognitive deficits during brain development and impairs self-renewal and differentiation of neural stem cells (NSCs). Tripartite motif 72 (TRIM72, also known as mitsugumin 53, MG53) is involved in tissue re...
Protocatechuic acid reduces H2O2-induced migration and oxidative stress of fibroblast-like synoviocytes in rheumatoid arthritis by activating Nrf2-Keap1 signaling pathway [0.03%]
(proto)儿茶酸通过激活Nrf2-Keap1信号通路降低滑膜成纤维样细胞H2O2诱导的迁移和氧化应激以治疗类风湿性关节炎
Yan Liu,Yucheng Zhang,Keke Zhang et al.
Yan Liu et al.
Honeycomb (Nidus vespae) is traditional Chinese medicine and can treat rheumatoid arthritis (RA), and protocatechuic acid (PCA) is a bioactive component of honeycomb. This study aimed to investigate whether PCA could reduce the H2O2-induced...
Preoperative anemia: Predictor of free flap reconstruction complications in head and neck cancer [0.03%]
头颈癌游离皮瓣重建术前贫血与术后并发症关系研究
Cheng Hung Tu,San Fu Hong
Cheng Hung Tu
Free flap reconstruction has been the mainstay among reconstruction surgeries for head and neck cancer. Intraoperative and postoperative hemoglobin (Hb) levels were both possible risk factors of flap failure and had been discussed widely. H...
GATA-binding protein 4 promotes neuroinflammation and cognitive impairment in Aβ1-42 fibril-infused rats through small nucleolar RNA host gene 1/miR-361-3p axis [0.03%]
GATA结合蛋白4通过小核仁RNA宿主基因1/miR-361-3p轴促进Aβ1-42纤维注入大鼠的神经炎症和认知障碍
Lidan Liu,Yanhui Peng,Wenping Liu et al.
Lidan Liu et al.
Aging with dysregulated metabolic and immune homeostasis stimulates pyroptosis, neuroinflammation, and cellular senescence, thus contributing to etiopathogenesis of Alzheimer's disease. GATA-binding protein 4 (GATA4) functions as a transcri...