Paeonol represses A549 cell glycolytic reprogramming and proliferation by decreasing m6A modification of Acyl-CoA dehydrogenase [0.03%]
苯酚通过降低长链酰基辅酶A脱氢酶的m6A修饰抑制A549细胞糖酵解重建和增殖
Lixin Zhang,Lihua Wu,Xiangrui Zhu et al.
Lixin Zhang et al.
Aberrant glycolytic reprogramming is involved in lung cancer progression by promoting the proliferation of non-small cell lung cancer cells. Paeonol, as a traditional Chinese medicine, plays a critical role in multiple cancer cell prolifera...
Pachymic acid protects hepatic cells against oxygen-glucose deprivation/reperfusion injury by activating sirtuin 1 to inhibit HMGB1 acetylation and inflammatory signaling [0.03%]
桃儿七酸通过激活SIRT1抑制HMGB1乙酰化和炎症信号来保护缺血再灌注损伤的肝细胞
Chengbiao Xue,Zhigao Xu,Zhongzhong Liu et al.
Chengbiao Xue et al.
Ischemia-reperfusion injury is an important cause of liver injury occurring during liver transplantation. It is usually caused by inflammatory response and oxidative stress-induced oxidative damage. Pachymic acid (PA) has various biological...
Ring-finger protein 5 attenuates oxygen-glucose deprivation and reperfusion-induced mitochondrial dysfunction and inflammation in cardiomyocytes by inhibiting the S100A8/MYD88/NF-κB axis [0.03%]
环指蛋白5通过抑制S100A8/MYD88/NF-κB轴缓解心肌细胞缺血再灌注导致的线粒体功能障碍和炎症反应
Xuesi Chen,Yingjie Wu,Yingchun Bao
Xuesi Chen
Mitochondrial dysfunction is closely intertwined with the progression of heart failure (HF). Ring-finger protein 5 (RNF5) is an E3 ubiquitin ligase, whose deletion induces the enhanced S100A8 expression. S100A8 regulates the mitochondrial d...
Investigation of the regulatory mechanism of lijie capsules on gut microbiota in rheumatoid arthritis [0.03%]
利节胶囊对类风湿关节炎肠道菌群调控机制的研究
Yanqiang Chen,Shaobin Qiu,Fei Qiu et al.
Yanqiang Chen et al.
Lijie Capsules (LJJN) are a classical Chinese herbal formula adopted to treat rheumatoid arthritis (RA) clinically, yet the regulatory mechanism underlying the protection of LJJN against RA has not been fully elucidated. Here, the animal mo...
Sericin improves memory and sociability impairments evoked by transient global cerebral ischemia through suppression of hippocampal oxidative stress, inflammation, and apoptosis [0.03%]
丝素蛋白通过抑制海马氧化应激、炎症和凋亡改善短暂性全脑缺血诱发的认知及社会行为障碍
Seyed Mehdi Vatandoust,Javad Mahmoudi,Shahrbanoo Oryan et al.
Seyed Mehdi Vatandoust et al.
Sericin (Ser) is a natural neuroactive macromolecule with diverse pharmacological properties, and our previous findings have shown its neuroprotective potentials. This study aimed to investigate the therapeutic potential of Ser on cognitive...
miR-22-3p ameliorates the symptoms of premature ovarian failure in mice by inhibiting CMKLR1 expression [0.03%]
miR-22-3p通过抑制CMKLR1表达缓解小鼠早期卵巢衰竭症状
Miaomiao Pan
Miaomiao Pan
Premature ovarian failure (POF) affects many adult women less than 40 years of age and leads to infertility. This study was aimed at exploring the improving effects of miR-22-3p on the symptoms of POF in mice by inhibiting chemokine-like re...
Calycosin inhibits gemcitabine-resistant lung cancer cells proliferation through modulation of the LDOC1/GNL3L/NFκB [0.03%]
锦灯笼素通过调节LDOC1/GNL3L/NF-κB途径抑制吉西他滨耐药的肺癌细胞增殖作用
Chi-Cheng Li,Cheng-You Lu,Chiung-Hung Hsu et al.
Chi-Cheng Li et al.
Lung cancer is the most common malignant cancer worldwide. Combination therapies are urgently needed to increase patient survival. Calycosin is a phytoestrogen isoflavone that has been reported previously to inhibit tumor cell growth, altho...
Breast cancer nipple discharge exosomal microRNAs are stable under degradative conditions [0.03%]
乳腺癌乳头分泌外泌体微小核糖核酸在降解条件下的稳定性研究
Ya-Wen Wang,Weiguo Zhang,Xu Chen et al.
Ya-Wen Wang et al.
We have previously shown that microRNAs (miRNAs) in nipple discharge are potential diagnostic biomarkers. In particular, exosomes are present in nipple discharge. Herein, we sought to elucidate the protective role of exosomes on miRNAs in n...
Abnormal expression of long non-coding RNA FGD5-AS1 affects the development of ovarian cancer through regulating miR-107/RBBP6 axis [0.03%]
长链非编码RNA FGD5-AS1的异常表达通过调节miR-107/RBBP6轴影响卵巢癌的发展
Wen Zhang,Jianguo Shi,Guoyan Liu
Wen Zhang
Long non-coding RNAs (lncRNAs) are important players in cancer development. LncRNA FGD5-AS1 has been reported as a potential oncogene in ovarian cancer (OC). The present paper focused on the action mechanism of FGD5-AS1 in OC. Clinical OC s...
Abnormal expression of long non-coding RNA FGD5-AS1 affects the development of ovarian cancer through regulating miR-107/RBBP6 axis [0.03%]
长链非编码RNA FGD5-AS1异常表达通过调控miR-107/RBBP6轴影响卵巢癌发展
Wen Zhang,Jianguo Shi,Guoyan Liu
Wen Zhang
Long non-coding RNAs (lncRNAs) are important players in cancer development. LncRNA FGD5-AS1 has been reported as a potential oncogene in ovarian cancer (OC). The present paper focused on the action mechanism of FGD5-AS1 in OC. Clinical OC s...