Ethyl isopropylamiloride downregulates Na,K-ATPase gene expression which confers cytotoxicity in primary proximal tubule cell cultures [0.03%]
乙异丙基氨利尿肽下调Na,K-ATP酶基因表达并使原代近端肾小管细胞培养的细胞发生毒性作用
H M Chiu,H H Lin,M J Tang
H M Chiu
Our original attempt was to examine whether inhibition of Na/H exchange in proximal tubule would affect the expression of basolateral membrane protein Na,K-ATPase. Three amiloride analogues were tested within the range of 10(-6) M to 10(-4)...
The antioxidative property of green tea against iron-induced oxidative stress in rat brain [0.03%]
绿茶防治铁过载所致大鼠脑氧化应激损伤的抗氧化作用研究
A M Lin,B Y Chyi,L Y Wu et al.
A M Lin et al.
The antioxidative property of green tea against iron-induced oxidative stress was investigated in the rat brain both in vivo and in vivo. Incubation of brain homogenates at 37 degrees C for 4 hours in vitro increased the formation of Schiff...
Nifedipine, verapamil and diltiazem block shock-wave-induced rises in cytosolic calcium in MDCK cells [0.03%]
硝苯地平、维拉帕米和地尔硫草阻断冲击波引起的MDCK细胞胞浆钙离子浓度升高现象
C R Jan,W C Chen,S N Wu et al.
C R Jan et al.
Nifedipine and verapamil have been shown previously to protect against renal function alterations induced by shock wave lithotripsy (SWL) in humans and rats; however, the mechanism is unclear. This study was aimed to examine whether these d...
The involvement of nitric oxide in synergistic neuronal damage induced by beta-amyloid peptide and glutamate in primary rat cortical neurons [0.03%]
一氧化氮参与β淀粉样蛋白与谷氨酸协同损害原代大鼠皮层神经元的作用及机制研究
S N Yang,W Y Hsieh,D D Liu et al.
S N Yang et al.
Abnormal extracellular accumulation of beta-amyloid (Abeta), the major component of senile plaques in the Alzheimer's brain and the excitatory amino acid glutamate are both considered to be associated with neurodegeneration. We studied whet...
The effect of trigeminal neurotomy on the alteration of local cerebral blood flow of normotensive and hypertensive rats in acute cold stress [0.03%]
三叉神经切断对正常血压和高血压大鼠急性冷应激时局部脑血流的影响
Y C Wang,J S Kuo,S Z Lin
Y C Wang
The cold season is reported to have the highest incidence of stroke in a year. Cold is usually detected by cold receptors in the face. The present studies were designed to test whether the trigeminal nerve plays a role in the regulation of ...
Effects of chronic exercise on muscarinic receptor-mediated vasodilation in rats [0.03%]
慢性运动对大鼠毒蕈碱受体介导的血管舒张的影响
H I Chen,Y L Liao
H I Chen
Previous studies have demonstrated that vascular responses to acetylcholine (ACh), an endothelium-dependent vasodilator, are enhanced in exercise-trained animals. In order to see if chronic exercise upregulates endothelial muscarinic (M) re...
Low susceptibility of stress ulcer in diabetic rats: role of cholinergic gastric motility [0.03%]
糖尿病大鼠应激性溃疡低易感性的研究及其胆碱能胃肠运动的调节作用
C R Hung
C R Hung
The induction of gastric hemorrhage ulcer by cold restraint stress (CRS) and the changes of cholinergic gastric motilities were studied in streptozotocin (STZ)-induced diabetic (DM) rats to compare with the age-matched normoglycemic rats. A...
Characteristics of spontaneous Ca2+ oscillations in bovine aortic endothelial cells in Ca2+-free solution [0.03%]
无钙溶液中牛主动脉内皮细胞的自发性钙振荡特征研究
J M Yang
J M Yang
In nominally Ca2+-free solution, the incidence of spontaneous Ca2+ oscillations in the cultured bovine aortic endothelial (BAE) cells may occur during superfusion. Application of 3 microM ATP induced a single Ca2+ transient regardless of th...
The role of the inhibitory nonadrenergic noncholinergic system in antigen-induced pulmonary hypersensitivity [0.03%]
抑制性肾上腺素能胆碱能系统的肺部抗敏作用
W J Lamm,Y L Lai,J Hildebrandt
W J Lamm
To study the role of the inhibitory nonadrenergic noncholinergic (i-NANC) system in regulating bronchial reactivity during antigen challenge, we first tested a blocker of the i-NANC system (oxyhemoglobin, HbO2, 2.5 microm) on the relaxation...
Transient frequency and intensity sensitivities of central auditory neurons determined with sweep tone [0.03%]
用扫频声测定中枢听神经元的音调和强度敏感性
T W Chiu,Y D Liu,P W Poon
T W Chiu
To determine the transient frequency and intensity sensitivities of central auditory neurons, we implemented an exponential sweep tone stimulus (2 sec in period, mean sweep rate 3.3 octave/sec), intensity of which varied systematically acro...