Metal specificity of an iron-responsive element in Alzheimer's APP mRNA 5'untranslated region, tolerance of SH-SY5Y and H4 neural cells to desferrioxamine, clioquinol, VK-28, and a piperazine chelator [0.03%]
阿尔茨海默病APP信使核糖核酸5'非翻译区铁反应元素的金属特异性及SH-SY5Y和H4神经细胞对去铁敏、氯喹酮、VK-28及哌嗪螯合剂的耐受性
S Bandyopadhyay,X Huang,H Cho et al.
S Bandyopadhyay et al.
Iron closely regulates the expression of the Alzheimer's Amyloid Precursor Protein (APP) gene at the level of message translation by a pathway similar to iron control of the translation of the ferritin L- and H mRNAs by Iron-responsive Elem...
Impact of selenium, iron, copper and zinc in on/off Parkinson's patients on L-dopa therapy [0.03%]
硒、铁、铜和锌对左旋多巴治疗的帕金森病患者的影响
G A Qureshi,A A Qureshi,S A Memon et al.
G A Qureshi et al.
We have quantitated CSF and serum levels of Selenium, iron, copper and zinc by Atomic absorption spectrophotometer in 36 patients with parkinson's disease all on L-dopa therapy. Out of these 19 showed on or positive response to L-dopa where...
Cerebral oligemia and iron influence in cerebral structures--element of morbus parkinson models? [0.03%]
脑低灌注和铁的影响作用与帕金森病的病因有关？
T A Sontag,C Heim,W Kolasiewicz et al.
T A Sontag et al.
The consequences of short phases of restricted cerebral blood flow and iron enrichment of striatal tissues resulted in an animal model that could correspond to the basic features of a model for Parkinson's disease. An automatic and computer...
J Salazar,N Mena,M T Núñez
J Salazar
Owing to its ability to undergo one-electron reactions, iron transforms the mild oxidant hydrogen peroxide into hydroxyl radical, one of the most reactive species in nature. Deleterious effects of iron accumulation are dramatically evidence...
E C Hirsch
E C Hirsch
Parkinson's disease (PD) is characterized by the death of dopaminergic neurons in the substantia nigra. This neuronal degeneration is associated with a strong microglial activation and iron accumulation in the affected brain structures. The...
S Yehuda,M Yehuda
S Yehuda
The long-term effects of rehabilitated infancy (1 year old) iron deficiency (ID) were examined at age 10. The children were examined for the following variables: auditory system function, the level of morning cortisol, I.Q. score (WISC-R), ...
Acute and chronic effects of developmental iron deficiency on mRNA expression patterns in the brain [0.03%]
发育性缺铁对大脑mRNA表达模式的急性与慢性影响
S L Clardy,X Wang,W Zhao et al.
S L Clardy et al.
Because of the multiple biochemical pathways that require iron, iron deficiency can impact brain metabolism in many ways. The goal of this study was to identify a molecular footprint associated with ongoing versus long term consequences of ...
Novel neuroprotective neurotrophic NAP analogs targeting metal toxicity and oxidative stress: potential candidates for the control of neurodegenerative diseases [0.03%]
靶向金属毒性和氧化应激的新型神经保护神经营养NAP类似物：控制神经退行性疾病的潜在候选药物
H Zheng,D Blat,M Fridkin
H Zheng
A large body of data indicates that a cascade of events contributes to the neurodegeneration in Alzheimer's disease (AD) and Parkinson's disease (PD). Metal (Fe, Cu, Zn) dyshomeostasis and oxidative stress are believed to play a pivotal rol...
A H V Schapira
A H V Schapira
Rasagiline is a novel, potent, irreversible inhibitor of monoamine oxidative B developed for the symptomatic treatment of Parkinson's disease. The drug has shown efficacy in improving motor features in both early and advanced Parkinson's di...
K Magyar,M Pálfi,V Jenei et al.
K Magyar et al.
During the last decades (-)-deprenyl has become the golden standard of MAO-B inhibitors. It possesses dopamine potentiating and antioxidant properties; however, its effects cannot be explained solely by the enzyme inhibitory action. (-)-Dep...