CYP 2E1 mutant mice are resistant to DDC-induced enhancement of MPTP toxicity [0.03%]
CYP 2E1突变小鼠抵抗DDC增强的MPTP毒性作用
C Viaggi,F Vaglini,C Pardini et al.
C Viaggi et al.
In order to reach a deeper insight into the mechanism of diethyldithiocarbamate (DDC)-induced enhancement of MPTP toxicity in mice, we showed that CYP450 (2E1) inhibitors, such as diallyl sulfide (DAS) or phenylethylisothiocyanate (PIC), al...
Y D Van Der Werf,H W Berendse,E J W van Someren et al.
Y D Van Der Werf et al.
Transcranial magnetic stimulation is a tool in the neurosciences to study motor functions and nervous disorders, amongst others. Single pulses of TMS applied over the primary motor cortex lead to a so-called cortical silent period in the re...
The long-term effects of the neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) on cognitive performance in rats [0.03%]
神经毒素1-三氯甲基-1,2,3,4-四氢-β-色满(TaClo)对大鼠认知表现长期影响的作用
T A Sontag,K W Lange,Ch Heim et al.
T A Sontag et al.
The neurotoxin 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) has been reported, both in vitro and in vivo models, to produce neurodegeneration and parkinsonian symptoms after prolonged exposure in rats. The aim of the present ...
Low dose methylphenidate improves freezing in advanced Parkinson's disease during off-state [0.03%]
低剂量的美金刚可改善帕金森病晚期off期的症状冻结现象
L Pollak,Y Dobronevsky,T Prohorov et al.
L Pollak et al.
Five men with advanced idiopathic Parkinson's disease (PD) were examined to assess the effect of low dose methylphenidate (MPD) on gait. The patients were tested during "off" state before and two hours after the intake of 10 mg MPD while wa...
Intrastriatal transplantation of mouse bone marrow-derived stem cells improves motor behavior in a mouse model of Parkinson's disease [0.03%]
骨髓源性干细胞的黑质内移植改善帕金森病模型小鼠的行为学症状
D Offen,Y Barhum,Y S Levy et al.
D Offen et al.
Strategies of cell therapy for the treatment of Parkinson's disease (PD) are focused on replacing damaged neurons with cells to restore or improve function that is impaired due to cell population damage. In our studies, we used mesenchymal ...
Neuroprotection by propargylamines in Parkinson's disease: intracellular mechanism underlying the anti-apoptotic function and search for clinical markers [0.03%]
丙炔胺类化合物在帕金森病中的神经营养作用：抗凋亡功能的细胞内机制及其临床标志物的研究
M Naoi,W Maruyama,H Yi et al.
M Naoi et al.
In Parkinson's and other neurodegenerative diseases, a therapeutic strategy has been proposed to halt progressive cell death. Propargylamine derivatives, rasagiline and (-)deprenyl (selegiline), have been confirmed to protect neurons agains...
Biochemistry of postmortem brains in Parkinson's disease: historical overview and future prospects [0.03%]
帕金森病死后脑的生化研究：历史回顾与未来展望
T Nagatsu,M Sawada
T Nagatsu
Biochemical studies on postmortem brains of patients with Parkinson's disease (PD) have greatly contributed to our understanding of the molecular pathogenesis of this disease. The discovery by 1960 of a dopamine deficiency in the nigro-stri...
Ginsenoside Rd attenuates neuroinflammation of dopaminergic cells in culture [0.03%]
稀有人参皂苷Rd抑制培养的多巴胺能神经元的炎症反应
W M Lin,Y M Zhang,R Moldzio et al.
W M Lin et al.
In Parkinson's disease clinical and experimental evidence suggest that neuroinflammatory changes in cytokines caused by microglial activation contribute to neuronal death. Experimentally, neuroinflammation of dopaminergic neurons can be evo...
Morphological substrates of parkinsonism with and without dementia: a retrospective clinico-pathological study [0.03%]
帕金森病伴或不伴有痴呆的形态学基础：回顾性临床病理研究
K A Jellinger
K A Jellinger
A retrospective study of a 50-year autopsy series of 900 patients with the clinical diagnosis of parkinsonism (31.2% with dementia) revealed pure Lewy body disease (LBD) in 84.9%, but only 44.7% with idiopathic Parkinson disease (PD); 16% w...
E C Hirsch
E C Hirsch
Ideally, animal models of neurodegenerative diseases should reproduce the clinical manifestation of the disease and a selective neuronal loss. In this review we will take as an example Parkinson's disease because its pathophysiology is well...