Antioxidant capacity in postmortem brain tissues of Parkinson's and Alzheimer's diseases [0.03%]
帕金森和阿尔茨海默病尸体脑组织的抗氧化能力
E Sofic,A Sapcanin,I Tahirovic et al.
E Sofic et al.
Oxidative stress has been associated with damage and progressive cell death that occurs in neurodegenerative disorders such as Parkinson's disease (PD) and Alzheimer's disease (AD). The aim of this study was to investigate the antioxidant c...
E Ch Wolters
E Ch Wolters
Parkinson's disease (PD) is a chronic, neurodegenerative disease with degeneration of the central dopaminergic neurons in the substantia nigra, leading to a depletion of dopamine (DA) in the striatum. This depletion causes the clinical hall...
The DONPAD-study--treatment of dementia in patients with Parkinson's disease with donepezil [0.03%]
多奈哌齐治疗帕金森病伴发痴呆的疗效研究(DONPAD)
T Müller,J Welnic,G Fuchs et al.
T Müller et al.
Inhibition of acetylcholinesterase improves symptoms of dementia in patients with Parkinson's disease (PD). Dementia in PD has a cumulative incidence of up to 80% and is mainly caused by a distinct cholinergic deficit. Objectives of this in...
Changing dopamine agonist treatment in Parkinson's disease: experiences with switching to pramipexole [0.03%]
帕金森病多巴胺激动剂的更换治疗——换用普拉克索的经验
H Reichmann,P Odin,H M Brecht et al.
H Reichmann et al.
1202 patients suffering from Parkinson's disease switched from other dopamine agonists to pramipexole under open conditions either abruptly or in an overlapping, gradual manner. Mostly insufficient effectiveness motivated the switch. The in...
S Fahn
S Fahn
Levodopa is the most efficacious drug to treat the symptoms of Parkinson's disease (PD) and is widely considered the "gold standard" by which to compare other therapies, including surgical therapy. Response to levodopa is one of the criteri...
M B H Youdim
M B H Youdim
Genetics of dystonia [0.03%]
扭转痉挛的遗传学研究进展
S Bressman
S Bressman
Primary torsion dystonia (PTD) has a broad clinical spectrum, with earlier onset of symptoms associated with more generalized muscle involvement. The causes for most dystonia are unknown although several monogenic subtypes have been identif...
M Hallett
M Hallett
Understanding of the pathophysiology of dystonia derives primarily from studies of focal dystonias. Physiological investigations have revealed a number of abnormalities that may reflect the genetic substrate that predisposes certain individ...
The discovery of the pressor effect of DOPS and its blunting by decarboxylase inhibitors [0.03%]
DOPS升压作用的发现及其被脱羧酶抑制剂削弱的现象
H Kaufmann
H Kaufmann
In the 1950s it was found that an artificial aminoacid, 3,4-threo-dihydroxyphenylserine (DOPS), was converted to norepinephrine (NE) in a single step by the enzyme L-aromatic amino acid decarboxylase (AADC), bypassing the need for the rate ...
J B Schulz
J B Schulz
Apoptosis, whether caspase-dependent or caspase-independent, has been implicated as one of the important mechanisms leading to the death of dopaminergic neurons in the substantia nigra of Parkinson's disease patients. Major advances of our ...