Fabio Lanfranco,Giovanna Motta,Matteo Baldi et al.
Fabio Lanfranco et al.
Ghrelin, a 28-amino-acid octanoylated peptide predominantly produced by the stomach, was discovered to be the natural ligand of the type 1a GH secretagogue receptor. Thus, it was considered as a natural GH secretagogue (GHS) additional to G...
Carlos Diéguez,Kátia Da Boit,Marta G Novelle et al.
Carlos Diéguez et al.
Ghrelin, a peptide hormone first discovered as the endogenous ligand of the growth hormone secretagogue receptor (GHS-R), is predominantly produced and released into the circulation by ghrelin cells (X/A-like) of the stomach fundus cells. G...
A J van der Lelij
A J van der Lelij
The cross-talk between several parts of the gut and the brain involves the exchange of information that enables an individual to optimize metabolism and to adapt it to potentially huge variations in caloric intake during, e.g. fasting and e...
Isabel Méndez,Claudia Vega,Miriam Zamorano et al.
Isabel Méndez et al.
Vasoinhibins are a family of peptides that inhibit blood vessel growth, dilation, permeability, and survival. They are generated by the proteolytic cleavage of prolactin by cathepsin D, matrix metalloproteases, and bone morphogenic protein-...
Marcello D Bronstein
Marcello D Bronstein
Acromegaly is a rare chronic and disabling disease with many comorbidities leading to a mortality rate three times higher than in the normal population, mainly due to cardiovascular diseases. Based on epidemiological evidence, the mortality...
Krystallenia I Alexandraki,Ashley B Grossman
Krystallenia I Alexandraki
The goals of ideal medical therapy for Cushing's disease should be to target the aetiology of the disorder, and thus surgery is the current 'gold standard' treatment. However, no effective drug that directly and effectively targets the adre...
M Theodoropoulou,M Labeur,M Paez Pereda et al.
M Theodoropoulou et al.
Despite considerable progress, there is still no medical treatment available for some kinds of pituitary tumors, in particular hormone inactive adenomas and corticotroph pituitary tumors. Surgical removal or at least debulking of the tumor ...
Diagnosis of cure in Cushing's syndrome: lessons from long-term follow-up [0.03%]
库欣综合征治愈的诊断：来自长期随访的经验教训
M J Barahona,E Resmini,N Sucunza et al.
M J Barahona et al.
It is generally assumed that endocrine 'cure' of hypercortisolism after successful treatment for Cushing's syndrome (CS) is associated with reversal of increased morbidity and mortality, typical of the active disease. However, recent data d...
Serum insulin-like growth factor-1 measurement in the diagnosis and follow-up of patients with acromegaly: preliminary data [0.03%]
胰岛素样生长因子-1在肢端肥大症诊断和随访中的测定：初步数据
Mirtha Guitelman,Graciela Radczuk,Natalia García Basavilbaso et al.
Mirtha Guitelman et al.
Measurement of serum insulin-like growth factor-1 (IGF-I) is the current method for diagnosing and monitoring acromegaly. However, the use of commercially available kits needs to be validated. In our study, we have investigated the use of t...
Enrico Gabellieri,Luca Chiovato,Mary Lage et al.
Enrico Gabellieri et al.
Growth hormone deficiency (GHD) in adults is a recognized syndrome which is defined biochemically within an appropriate clinical context. Clinically, patients investigated for GHD should include those with signs and symptoms of hypothalamic...