Guodong Zhang,Alvin V Terry Jr,Michael G Bartlett
Guodong Zhang
Antipsychotic drugs are popular for the treatment of schizophrenia and other psychoses. In general, antipsychotics are administered in oral doses of only a few milligrams per day and they are widely metabolized in the body. Therefore, the c...
Boldenone, testosterone and 1,4-androstadiene-3,17-dione determination in faeces from horses, untreated and after administration of androsta-1,4-diene-3,17-dione (boldione) [0.03%]
马匹粪便中异雄烯二酮给药前后的苯丙酸诺龙、睾丸素和雄烯二酮的测定
M A Popot,S Boyer,L Menaut et al.
M A Popot et al.
Faeces, which could be a potential alternative medium for doping control, have been used for the detection of 1,4-androstadiene-3,17-dione administration to the horse. Semi-quantitative analyses of 1,4-androstadiene-3,17-dione, testosterone...
Liquid chromatography/electrospray ionization tandem mass spectrometry for the quantification of mitiglinide in human plasma: validation and its application to pharmacokinetic studies [0.03%]
人血浆中米格列奈定量的液相色谱-串联质谱分析方法的验证及其在药代动力学研究中的应用
Yan Zhang,Likun Ding,Yun Tian et al.
Yan Zhang et al.
A sensitive and specific method was developed and validated for the determination of mitiglinide in human plasma using liquid chromatographic separation with electrospray ionization tandem mass spectrometric detection. Acidified plasma samp...
Identification of major alkaloids and steroidal saponins in rat serum by HPLC-diode array detection-MS/MS following oral administration of Huangbai-Zhimu herb-pair Extract [0.03%]
高效液相色谱二级质谱及二极管阵列检测法结合研究黄柏知母药对口服给药大鼠血浆中主要生物碱和甾体皂苷成分
Chunhui Ma,Mingsong Fan,Yihong Tang et al.
Chunhui Ma et al.
Huangbai-Zhimu herb-pair (HBZMHP) is a widely used Chinese traditional medicine formula in treating various diseases; however, its active components have remained unknown. In this paper, serum chemistry and combined high-performance liquid ...
Determination of the lipophilic antipsychotic drug ziprasidone in rat plasma and brain tissue using liquid chromatography-tandem mass spectrometry [0.03%]
采用液相色谱-串联质谱法测定大鼠血浆和脑组织中抗精神病药齐拉西酮残留量
Guodong Zhang,Alvin V Terry Jr,Michael G Bartlett
Guodong Zhang
A simple, sensitive and robust liquid chromatography/electrospray ionization tandem mass spectrometry (LCESI-MS/MS) method with low matrix effects was developed and validated for the quantification of the lipophilic antipsychotic ziprasidon...
Determination and pharmacokinetic study of nodakenin in rat plasma by RP-HPLC method [0.03%]
RP-HPLC法测定京尼平苷并进行药代动力学研究
Peng Zhang,Fei Li,Xiu-Wei Yang
Peng Zhang
A simple, sensitive and selective RP-HPLC method has been developed for quantification of nodakenin in rat plasma. Nodakenin in rat plasma was extracted with acetonitrile, which also acted as a deproteinization agent. Chromatographic separa...
Simultaneous determination of beta-blockers in human plasma using liquid chromatography-tandem mass spectrometry [0.03%]
用人血浆液相色谱-串联质谱法同时测定β受体阻滞剂类药物
Hironobu Umezawa,Xiao-Pen Lee,Yoshiko Arima et al.
Hironobu Umezawa et al.
A detailed procedure for the analysis of four beta-blockers, acebutolol, labetalol, metoprolol and propranolol, in human plasma by high-performance liquid chromatography (LC)-tandem mass spectrometry (MS-MS) using an MSpak GF column, which ...
Development of a 6-hydroxychroman-based derivatization reagent: application to the analysis of 5-hydroxytryptamine and catecholamines by using high-performance liquid chromatography with electrochemical detection [0.03%]
一种6-羟基黄烷衍生物化试剂的开发及其在高效液相色谱电化学检测中分析5-羟色胺和儿茶酚胺中的应用
Tsukasa Sasaki,Takeshi Fukushima,Madoka Ohishi et al.
Tsukasa Sasaki et al.
We developed a novel derivatization reagent, (2R)-2,5-dioxopyrrolidin-1-yl-2,5,7,8-tetramethyl-6-(tetrahydro-2H-pyran-2-yloxy)chroman-2-carboxylate (NPCA), for electrochemical (EC) detection in HPLC. NPCA was synthesized from (R)-(+)-6-hydr...
New applications of cyclodextrins in electrically driven chromatographic systems: a review [0.03%]
环糊精在电驱动色谱系统中的新应用：综述研究论文
T Cserháti
T Cserháti
The new achievements in the employment of native and derivatised cyclodextrins in various electrically driven chromatographic systems are compiled. Cyclodextrin-assisted separation techniques are concisely described and critically evaluated...
Sensitive and specific LC-MS assay for quantification of digoxin in human plasma and urine [0.03%]
一种检测人体血浆和尿液中毛花苷C的灵敏而准确的方法：LC-MS定量测定法
Brian J Kirby,Tom Kalhorn,Mary Hebert et al.
Brian J Kirby et al.
Digoxin, a commonly prescribed cardiac glycoside with a narrow therapeutic window, is routinely used in pharmacokinetic studies to assess the in vivo activity of the drug efflux pump P-glycoprotein. To minimize adverse events, a sub-therape...