Sensitive liquid chromatography tandem mass spectrometry method for the quantification of Quetiapine in plasma [0.03%]
用于测定血浆中奎硫平的敏感液相色谱-质谱联用的定量方法
Ramakrishna Nirogi,Gopinadh Bhyrapuneni,Vishwottam Kandikere et al.
Ramakrishna Nirogi et al.
A sensitive high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of quetiapine in rat plasma. Following liquid-liquid extraction, the analyte was separated using a gradien...
Assessing the issue of instability due to Michael adduct formation in novel chemical entities possessing a carbon-carbon double bond during early drug development--applicability of common laboratory analytical protocols [0.03%]
Akshanth Reddy Polepally,Venkata V Pavan Kumar,Ravikanth Bhamidipati et al.
Akshanth Reddy Polepally et al.
The discovery of small-molecule novel chemical entities (NCEs) is often a complex play between appropriate structural requirements and optimization of the desired efficacy, safety and pharmacokinetic properties. One of the typical structura...
Development of a simultaneous liquid-liquid extraction and chiral derivatization method for stereospecific GC-MS analysis of amphetamine-type stimulants in human urine using fractional factorial design [0.03%]
W R Wan Aasim,S H Gan,S C Tan
W R Wan Aasim
A stereospecific gas chromatography-mass spectrometry analysis method for amphetamine-type stimulants in human urine was recently developed. For maximum efficiency, liquid-liquid extraction and chiral derivatization of the analytes using (R...
Yaping Zhang,Lei Shan,Wen Xu et al.
Yaping Zhang et al.
A rapid and sensitive method using liquid chromatography-tandem mass spectroscopy (LC-MS/MS) was developed and validated for the quantitative determination of cynandione A in rat plasma and tissues. The plasma samples were pretreated by liq...
Development of a rapid and sensitive liquid chromatography/tandem mass spectrometry method for the determination of 1,2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE), a novel anti-cancer agent in rat plasma [0.03%]
Hai-Yan Zhou,Gui-Fang Dou,Zhi-Yun Meng et al.
Hai-Yan Zhou et al.
A rapid and sensitive liquid chromatography/electrospray ionization tandem mass spectrometric (LC/ESI-MS/MS) method has been developed to determine 1, 2-[bis(1,2-benzisoselenazolone-3(2H)-ketone)]-ethane (BBSKE), a novel antineoplastic agen...
Shih-Ming Chen,Mau-Chih Hsieh,Su-Hui Chao et al.
Shih-Ming Chen et al.
A sample of 0.104 M nicardipine in methanol was photoirradiated with a Philips 400 W UV lamp for 3 h in a photochemical chamber. A total of four major photoproducts were found from the HPLC chromatogram. The same sample was used for taking ...
Simultaneous determination of udenafil and its active metabolite, DA-8164, in human plasma and urine using ultra-performance liquid chromatography-tandem mass spectrometry: application to a pharmacokinetic study [0.03%]
Soo Kyung Bae,Min Jeong Kang,Chang-Woo Yeo et al.
Soo Kyung Bae et al.
A rapid, sensitive, and simple ultra-performance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) method for the determination of udenafil and its active metabolite, DA-8164, in human plasma and urine using sildenafil as an inter...
Pharmacokinetic study of three active flavonoid glycosides in rat after intravenous administration of Trollius ledebourii extract by liquid chromatography [0.03%]
Deqiang Li,Qiao Wang,Lei Xu et al.
Deqiang Li et al.
A selective and sensitive reversed-phase high-performance liquid chromatography method was developed and validated for the simultaneous determination of orientin-2''-O-beta-L-galactopyranosyl (OGA), orientin and vitexin in rat plasma. Blood...
Identification of leucine-enkephalin radical oxidation products by liquid chromatography tandem mass spectrometry [0.03%]
Conceição Fonseca,Pedro Domingues,Ana Reis et al.
Conceição Fonseca et al.
The oxidation of the peptide leucine-enkephalin (YGGFL) induced by the hydroxyl radical (HO*), formed under Fenton-like conditions [Cu (II)/H(2)O(2)], was studied and monitored by LC-MS. The oxidation products identified included products r...