Zheng Ao,De-wu Liu,Geng-yuan Cai et al.
Zheng Ao et al.
The cloning technique, also called somatic cell nuclear transfer (SCNT), has been successfully established and gradually applied to various mammalian species. However, the developmental rate of SCNT mammalian embryos is very low, usually at...
Gan-cheng Wang,Ma Ming,Yan-zhen Ye et al.
Gan-cheng Wang et al.
High-throughput screening, a powerful tool for the discovery of functionally important genes responsible for certain phenotypes, is performed according to loss-of-function or gain-of-function strategies. RNAi technology or knockout approach...
Yuan-feng Li,Yubo Han,Peng-bo Cao et al.
Yuan-feng Li et al.
Steady progress has been achieved in the medical genetics in China in 2015, as numerous original researches were published in the world's leading journals. Chinese scientists have made significant contributions to various fields of medical ...
Locked nucleic acid couples with Fok I nucleases to target and cleave hepatitis B virus's gene in vitro [0.03%]
锁核苷酸与Fok I核酸酶结合靶向并切割乙型肝炎病毒基因(in vitro)
Li Ma,Hong-yan Chen,Hua-xing Zhu et al.
Li Ma et al.
Hepatitis B virus (HBV) is a dented double-stranded DNA virus. After infecting human hepatic cells, it forms cccDNA that replicates persistently and integrates randomly into the host’s genome during the process of reserve transcription. On...
Genome-wide identification and expression profiling of the C2H2-type zinc finger protein transcription factor family in tobacco [0.03%]
烟草C2H2型锌指蛋白转录因子家族的基因组范围鉴定及表达分析
Ming-lei Yang,Jiang-tao Chao,Da-wei Wang et al.
Ming-lei Yang et al.
C2H2 zinc finger protein transcription factor family members have important biological functions in eukaryotes. They not only bind DNA and RNA, but also interact with proteins. In this study, 118 members of the tobacco C2H2 zinc finger prot...
Characterization of a cluster of CTCF-binding sites in a protocadherin regulatory region [0.03%]
靶向原钙粘素调节区的CTCF结合位点簇的表征研究
Ya-nan Zhai,Quan Xu,Ya Guo et al.
Ya-nan Zhai et al.
The mammalian clustered protocadherin (Pcdh) locus contains more than 50 highly-similar genes arrayed in tandem. These Pcdh genes are organized into three closely-linked clusters (Pcdhα, Pcdhβ, and Pcdhγ). The encoded PCDH proteins play ...
Hai-wei Shuai,Yong-jie Meng,Xiao-feng Luo et al.
Hai-wei Shuai et al.
Seed dormancy and germination are attractive topics in the fields of plant molecular biology as they are key stages during plant growth and development. Seed dormancy is intricately regulated by complex networks of phytohormones and numerou...
Min Zheng,Jun-wu Ma
Min Zheng
Gout is one of the most common inflammatory arthritis caused by hyperuricaemia, which is affected by both genetic factors and environmental factors. Early researches show that a few of rare monogenic mutations, such as PRPS1 and HPRT1 mutat...
Sun-yang Ying,Jia-xiu Xiong,Hong-xu Mai et al.
Sun-yang Ying et al.
Telomerase is composed of the catalytic subunit TERT (Telomerase reverse transcriptase),RNA subunit TERC (Telomerase RNA component) and other telomerase associated proteins. These two compartments with other telomerase subunits can assemble...
Xiao Zhang,Gui-fang Jia
Xiao Zhang
N(6)-methyladenosine (m(6)A) is one of the most prevalent internal modifications in eukaryotic messenger RNA. The dynamic and reversible modification is installed by methyltransferase complex charactered three subunits: METTL3 (Methyltransf...