Integrating cases, enhancing interaction, and promoting learning through assessment: teaching reform and practical outcomes of medical genetics under the OBE concept [0.03%]
基于OBE理念的医学遗传学课程教学改革与实践效果
Shi-Qian Liang,Fan Fan,Yi-Yang Hu et al.
Shi-Qian Liang et al.
In the new era, the teaching of Medical Genetics requires medical students to not only master solid knowledge, but also possess practical abilities in diagnosing and treating clinical genetic diseases. This paper systematically elaborates o...
Machine learning-based geographical ancestry inference model for the Han Chinese population [0.03%]
基于机器学习的汉族人群地理谱系推断模型
Shuai-Qi Wang,Chun-Nian Wang,De-Qin Zhang et al.
Shuai-Qi Wang et al.
The Han Chinese population exhibits a complex genetic structure characterized by subtle yet discernible regional differentiation. Elucidating this fine-scale population structure and developing robust models for biogeographical ancestry inf...
Yu-Qin Hu,Fan Liu,Ying Li et al.
Yu-Qin Hu et al.
Vascular development begins with vasculogenesis during early embryogenesis. This process is controlled by a highly integrated, multi-layered molecular network. However, the role of post-transcriptional regulation in this context remains poo...
Potential risk proteins for suicide attempts: multi-omics analysis based on European population biobanks [0.03%]
基于欧洲人群生物库的多组学分析所得的潜在自杀尝试风险蛋白
Mei-Qi Peng,Bo Xiang
Mei-Qi Peng
Suicide is defined as an intentional act of ending one's own life. Suicide attempt (SA) is a significant risk factor for suicide death. Research on SA has progressed from socio-psychological perspectives to the molecular and genetic levels....
Assessment of biological age for aging evaluation and its clinical applications [0.03%]
生物学年龄的评估及其临床应用评价
Dan-Qing Huang,Jing Guo,Yan Guo et al.
Dan-Qing Huang et al.
As the global population ages, the development of methods that can accurately quantify individual aging status and overcome the limitations of chronological age assessment has become an important need in aging research and precision medicin...
Lu Tian,Qian Liu,Shan Cen et al.
Lu Tian et al.
Transposons, also known as jumping genes, are DNA sequences capable of relocating within or between chromosomes. Long interspersed element-1 (LINE-1), the only autonomously active retrotransposon in the human genome, plays a critical role i...
Operational model of the French livestock and poultry genetic resources management system and its implications [0.03%]
法国畜禽遗传资源管理体系运行模式及其启示
Xiao-Jing Zhang,Ai-Ling Wang,Jing-Juan Zhao et al.
Xiao-Jing Zhang et al.
As the largest agricultural producer in the European Union, France has established a mature and systematic livestock and poultry genetic resources management system. Based on comprehensive domestic legislation and effectively aligned with E...
Construction and implementation of an ICF-based integrated teaching model for genetic disease severity assessment [0.03%]
基于ICF的遗传病严重程度评估综合教学模式的构建与实施
Qing-Li Quan,Mei-Xing Yu,Hai-Ou Jiang
Qing-Li Quan
To enhance the competency of clinical medicine students in evaluating the severity of genetic disorders, this study first modularized an assessment of genetic diseases severity based on the World Health Organization's International Classifi...
Identification and prenatal genetic testing of pathogenic variants in a case of myoclonus-dystonia syndrome [0.03%]
肌张力不全症候群致病基因变异的鉴定及产前基因检测
Han-Xiao Ou,Xia Zhou,Li-Ya Chen et al.
Han-Xiao Ou et al.
Myoclonus-dystonia syndrome (MDS) is a movement disorder syndrome characterized primarily by myoclonus as the core feature. In this study, we reported a case of MDS with myoclonus as the prominent feature, which was accompanied by learning ...
Case Reports
Yi chuan = Hereditas. 2026 Jun;48(6):638-647. DOI:10.16288/j.yczz.25-235 2026
A novel strategy to enhance precise targeting of the RNA base editor mxABE [0.03%]
一种增强RNA基础编辑器mxABE精确靶向的新策略
Tan Liu,Hui-Jie Jiang,Xue-Lang Wang et al.
Tan Liu et al.
Single nucleotide variations (SNVs) represent the most common form of pathogenic mutations in humans, while base editing technology offers an ideal solution for treating such pathogenic variants. RNA editing has become a hotspot in current ...