GPX8 inhibits myogenic differentiation and promotes slow myofiber formation of porcine skeletal muscle satellite cells [0.03%]
GPX8通过抑制肌源性分化促进猪骨骼肌卫星细胞慢肌纤维的形成
Teng-Fei Zheng,Xin-Yue Liang,Ying-Ying Meng et al.
Teng-Fei Zheng et al.
Glutathione peroxidase 8(GPX8) is a key member of the glutathione peroxidase family. Genome-wide association studies (GWAS) have indicated that GPX8 is highly associated with growth and carcass traits of pigs. Using porcine skeletal muscle ...
pnr cooperate with fred to regulate SOP cell fate both positively and negatively in the medial notum of Drosophila [0.03%]
PNR与FREEDOM合作调控Drosophila中胸背板SOP细胞命运的正负调控机制
Kai-Yue Song,Yi-Fei Zhang,Yao Zhang et al.
Kai-Yue Song et al.
According to the "Prepattern Hypothesis", the development of dorsal sensory organ precursors (SOP) in Drosophila melanogaster depends on the sequential regulation of prepattern genes, proneural genes, and neurogenic genes. In most cases, ec...
Characterizing transcriptomic signatures and identifying hub differentially expressed genes in resistant hypertension [0.03%]
难治性高血压的转录特征及关键差异基因识别
Tong Jiang,Shi-Jing Peng,Shan-Shan Wang et al.
Tong Jiang et al.
Resistant hypertension (RH) is one of the high-risk types within the spectrum of hypertensive disorders, characterized by a complex pathogenesis. To identify hub differentially expressed genes (DEGs) associated with this disease, this study...
Progress on miRNAs involved in regulating plant responses to drought and salt stresses [0.03%]
植物microRNA参与调节植物响应干旱和盐胁迫的研究进展
Hao-Dong Li,Jia-Xin Meng,Hua Wang et al.
Hao-Dong Li et al.
Drought and salt stress are common abiotic constraints that limit plant growth, development, and reproduction. In response, plants have evolved complex molecular regulatory networks enabling them to perceive external stresses acutely and in...
Advances in base editing technology and the construction of precise zebrafish disease models [0.03%]
基于编辑技术的研究进展及精准斑马鱼疾病模型的构建
Shao-Hui Zheng,Yang Liu,Xin-Xin Xia et al.
Shao-Hui Zheng et al.
Single nucleotide variants (SNVs) are among the primary pathogenic factors of human genetic diseases, accounting for a significant proportion of all mutation types. Conducting in-depth research on the pathogenic significance of these mutati...
Xin-Ran Li,Yan-Han Feng,Zhi-Dan Xia
Xin-Ran Li
Sarcopenia is an age-related degenerative disease characterized by progressive loss of skeletal muscle mass and function, resulting severe clinical outcomes such as falls, disability, and increased all-cause mortality, thereby significantly...
Expert consensus on the morphological characteristics diagnostic criteria and genetic counseling of human chromosomal polymorphisms [0.03%]
人类染色体多态性形态特征、诊断标准和遗传咨询专家共识
Bing-Huan Weng,Song-Bin Fu,Yu-Lin Jiang et al.
Bing-Huan Weng et al.
Karyotype analysis is a routine prenatal diagnostic procedure in genetic diagnosis and counseling. Chromosomal polymorphisms are frequently observed in karyotyping. However, the absence of standardized criteria for defining polymorphisms ha...
A journey into biological complexity: continuing the legacy of Doug and Bill [0.03%]
生物学复杂性探索：传承Doug和Bill的遗产
Miao-Ling Yang,Zhuo Du
Miao-Ling Yang
Given the inherent complexity, hierarchical organization, and dynamic nature of living systems, there is no single best strategy for investigation, and priorities shift with the evolution of the life sciences. In the 1990s, two classic stor...
Changes of epigenetic modification and donor cell metabolic status can improve the developmental efficiency of canine-porcine interspecies somatic cell nuclear transfer embryos [0.03%]
表观修饰及供体细胞代谢状态的改变可提高犬-猪跨物种体细胞克隆胚胎的发育效率
Yan-Xia Yan,Yu-Han Zhang,Zhen-Fang Wu et al.
Yan-Xia Yan et al.
To explore new ways to improve canine cloning efficiency, this study compared the effects of different concentrations and treatment times of glycolysis promoter PS48 and epigenetic modifiers (DNA methylase inhibitor RG108 and histone deacet...
Karyotype and genome characterization analysis of Chilobrachys jingzhao (Theraphosidae: Chilobrachys) [0.03%]
Jingzhao华平狼蛛的染色体核型和基因组特征分析
Yu-Xuan Zhang,Meng-Ying Zhang,Han-Ting Yang et al.
Yu-Xuan Zhang et al.
The medicinal preparation of Chilobrachys jingzhao possesses various therapeutic properties, including anti-inflammatory, detoxifying, analgesic, and anti-edema effects. However, research on its genetic background and toxin mechanisms is he...