Typological and ancient DNA evidences reveal the influence of Ming dynasty migration on the Shengjizui population in Bishan, Chongqing [0.03%]
类型学和古DNA证据揭示明初移民对重庆bishan地区shengjizui人群的影响
Bo-Xuan Zhao,Lei Gao,Zi-Qing Lin et al.
Bo-Xuan Zhao et al.
Historical migration activities have played a crucial role in the exchange and dissemination of populations and cultures, leading to significant cultural transformations in certain regions. Previous research has often focused on historical ...
Application of ultrasound and artificial intelligence in the prediction of fetal chromosomal numerical abnormalities [0.03%]
超声联合人工智能技术在胎儿染色体非整倍体畸形产前筛查中的应用研究进展
Lin-Yao Tang,Jing-Rou-Zi Wu,Ge Lin
Lin-Yao Tang
Fetal chromosomal numerical abnormalities is a significant cause of pregnancy loss and birth defects. Ultrasound has emerged as a critical modality for fetal chromosomal anomaly screening due to its real-time capability, repeatability, and ...
Current understanding of mitochondrial DNA genetic diseases and gene therapy [0.03%]
线粒体DNA遗传病的基因治疗研究进展与挑战
Cheng Tang,Shun-Qing Xu,Han-Zeng Li
Cheng Tang
Mitochondria, as crucial organelles within eukaryotic cells, have their proteins and RNAs encoded by both the nuclear genome and the mitochondrial genome. They play vital roles in energy regulation, cellular metabolism, signal transduction,...
Advances in functional mechanisms of genomic G-quadruplex structures in transcriptional regulation [0.03%]
基因组G-四链体结构在转录调控中的功能机制研究进展
Zhen-Zhen He,Xiao-Feng Chen,Yue Hou et al.
Zhen-Zhen He et al.
As a canonical non-B DNA secondary structure, the G-quadruplex (G4) dynamically regulates core biological processes, including telomere homeostasis, DNA replication and gene transcription/translation-through its unique four-stranded conform...
Tian-Li Guo,Tao Zhang,Hua Guan et al.
Tian-Li Guo et al.
In the field of forensic science, mixed DNA evidence obtained from crime scenes often contains genetic information from multiple individuals, and its accurate interpretation is crucial for case investigation and judicial decision-making. Wi...
Effect of V-ATPase a3 subunit on microglial phagosome maturation in zebrafish [0.03%]
V-ATP酶a3亚基对斑马鱼小胶质细胞吞噬体成熟的影响
Han-Jing Kou,Zhi-Bin Huang,Wen-Qing Zhang et al.
Han-Jing Kou et al.
Microglia, as the resident immune cells of the central nervous system (CNS), maintain neural homeostasis by orchestrating the clearance of necrotic neurons, cellular debris, and pathogens through phagocytosis. This intracellular process inv...
Exploration of the regulatory function of genetic variants at FAM167A-BLK locus in systemic lupus erythematosus [0.03%]
探讨FAM167A-BLK位点遗传变异在系统性红斑狼疮发病中的调控功能研究
Ke Li,Xiao-Rong Zhou,Dong-Li Zhu et al.
Ke Li et al.
Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease with multi-organ involvement. The FAM167A-BLK locus at 8p23 has been identified as a genetic susceptibility locus for SLE by previous genome-wide association studies (GW...
Function of Bcl-2 gene and its mechanism on body size adaptive evolution in primates [0.03%]
Bcl-2基因在灵长类体型适应性进化中的功能及其机制研究
Run Li,Hong Shi
Run Li
Significant body size variations exist among different primate species. To investigate the genes influencing primate body size evolution, this study employed evolutionary genetics approaches to analyze functional differences and natural sel...
Lei Miao,Ke-Lai Kang,Chi Zhang et al.
Lei Miao et al.
Short tandem repeat (STR) is a significant genetic marker for the identification of forensic DNA. DNA databases worldwide, including those in China, are established based on STR markers. Length- and sequence-based polymorphism are two featu...
Jia-Qiang Chen,Mei Ding
Jia-Qiang Chen
Extracellular vesicles (EVs) are membrane-bound particles released by cells into the extracellular microenvironment. In the nervous system, EVs serve as critical mediators of biomolecule trafficking and intercellular communication. These ve...