The mechanism of synpo in intracerebral hemorrhage using a zebrafish model [0.03%]
模式生物斑马鱼中关于synpo在脑出血机制中的作用研究
Pei-Dong Ouyang,Jia-Lan Tang,Cheng-Chao Wu et al.
Pei-Dong Ouyang et al.
Intracerebral Hemorrhage (ICH) is a stroke subtype with high mortality, and its core pathological mechanism involves the disruption of cerebrovascular homeostasis. Genetic factors play a crucial role in ICH pathogenesis, underscoring the im...
Genome-wide association study of body size traits in dairy goats integrating structural variants [0.03%]
整合结构变异的奶山羊体型性状全基因组关联分析
Yan-Shuai Feng,Jia-Xin Li,Jiong-Yao Zhao et al.
Yan-Shuai Feng et al.
Body size traits serve as crucial phenotypic indicators of body conformation and growth, showing a close correlation with production performance. To elucidate the genetic basis of these traits and identify potential molecular markers in Saa...
Yu-Tian Yang,Cai-Hui Wang,Zhi-Kun Ma et al.
Yu-Tian Yang et al.
Ancient DNA technology directly retrieves genetic information from preserved biological materials, thereby offering significant advantages for elucidating species origins and evolution. In recent years, ancient DNA studies have yielded sign...
Analysis and application of sequence polymorphism features of 41 forensic Y-chromosome short tandem repeat loci [0.03%]
41个法医Y染色体短串联重复序列基因座的多态性特征分析及应用
Lei Miao,Chi Zhang,Ke-Lai Kang et al.
Lei Miao et al.
Y chromosome short tandem repeat (Y-STR) is an important genetic marker in forensic practices. Length-based Y-STR genotyping method has been used to screen paternal lineages and successfully solved many serious cases. However, it is hard to...
Advances in high-throughput screening of cyclic peptide drugs using mRNA display technology [0.03%]
基于mRNA展示技术的环肽药物高通量筛选研究进展
Shuang Wang,Xue Zhu,Jing Fang et al.
Shuang Wang et al.
Cyclic peptides have emerged as a promising therapeutic modality for targeting classically deemed "undruggable" protein that defy conventional small-molecule intervention. Their rigid conformations improve binding affinity, selectivity and ...
Genomic prediction of growth trait phenotypes in Large White pigs using a chromosome-encoded multi-head self-attention model [0.03%]
基于染色体编码的多头自注意力模型的约克夏猪生长性状表型预测
Wen-Xuan Zhou,Zhen-Jian Zhao,Dong Chen et al.
Wen-Xuan Zhou et al.
With the widespread adoption of genome sequencing technologies, predicting complex traits using genomic markers has become a key component in breeding programs. However, the high dimensionality and sparsity of genomic data, along with the c...
Multi-stage transcriptomic analysis of mouse embryonic lethality induced by homozygous knockout of the Vrtn gene [0.03%]
Vrtn基因纯合子敲除诱导的小鼠胚胎致死的多阶段转录组分析
Ya-Xin Deng,Bao-Jun Ding,Hong-Chun Li et al.
Ya-Xin Deng et al.
The Vrtn gene, a recently identified regulator of embryonic development and stem cell pluripotency, is essential for embryonic survival, as its homozygous knockout (Vrtn-/-) leads to lethality in mice at approximately embryonic day 12.5 (E1...
Identification of biomarkers for non-obstructive azoospermia based on microRNA and bioinformatics screening [0.03%]
基于微小核糖核酸和生物信息学筛选的非梗阻性无精子症生物标志物识别
Zhi-Hong Li,Miao-Qi Chen,Xiao-Jun Yuan et al.
Zhi-Hong Li et al.
MicroRNAs (miRNAs) play an important role in the occurrence of non-obstructive azoospermia (NOA). Nevertheless, there is still a lack of research on the molecular mechanisms by which miRNAs regulate target genes to mediate NOA at present. I...
Potential of SERINC2 as a biomarker in tumor prognosis and immunology: analysis from pan-cancer studies [0.03%]
泛癌分析揭示SERINC2作为肿瘤预后和免疫学生物标志物的潜力
Min Zhao,Hui-Qi Ying,Yi-Lei Yang et al.
Min Zhao et al.
Serine incorporator (SERINC) is a family of transmembrane protein involved in lipid synthesis. Among its family members, SERINC2 has been implicated in tumor pathogenesis. Pancreatic carcinoma (PAAD), a highly malignant tumor characterized ...
Xin-Yue Zhu,Kun-Long Hu,Wen-Huan Xu et al.
Xin-Yue Zhu et al.
N4-acetylcytidine (ac4C) is an emerging RNA epigenetic modification that has attracted considerable attention in the field of epitranscriptomics in recent years. This modification is widely present in tRNA, rRNA, mRNA, and various non-codin...