Xiao-Peng Xu,Xiao-Ying Fan
Xiao-Peng Xu
Expression quantitative trait loci (eQTL) represent genetic variants that regulate gene expression levels. eQTL analysis has become a crucial method for identifying the functional roles of disease-associated genetic variants in the post-gen...
Yu Liang,Wei Wu
Yu Liang
With the rapid development of high-throughput sequencing technology in the past decade, an increasing number of sequencing methods targeting different types of DNA damage have been developed and widely used in the field. These technologies ...
Yi-Chen Que,Qing-Quan Liu,Yi-Chi Xu
Yi-Chen Que
Illustrating molecular mechanisms of human embryonic development has always been one of the most significant challenges in biology. The scarcity of human embryo samples, the difficulty in dissecting embryo samples, and the complex structure...
Identification of a pathogenic variant and pre-implantation genetic testing for a Chinese family affected with split-hand/foot malformation [0.03%]
分裂手足畸形中国患者的致病突变鉴定及胚胎种植前遗传学检测
Li-Bin Mei,Yi-Yuan Zhang,Xian-Jing Huang et al.
Li-Bin Mei et al.
Split-hand/foot malformation is a serious congenital limb malformation characterized by syndactyly and underdevelopment of the phalanges and metatarsals. In this study, we reported a case of a fetus with hand-foot cleft deformity. Whole exo...
Analysis of expression characteristics and identification of interaction proteins of transcription factor BnaABI5 in Brassica napus [0.03%]
油菜转录因子BnaABI5的表达特性分析及其互作蛋白鉴定
Qian-Qian Ao,Fang-Xiao Lu,Liu-Qing Yang et al.
Qian-Qian Ao et al.
Rapeseed is one important oil crop in China. However, its planting benefit is frequently affected by environmental stresses such as drought in the northwest region of China. The abscisic acid(ABA) signaling pathway plays an important role i...
Effects of SvAPETALA1-5 gene on floral organ development in Senecio vulgaris [0.03%]
SvAPETALA1-5基因对鼠耳芥花器官发育的影响研究
Yu-Na Zhang,Yan-Min Hao,Min-Long Cui et al.
Yu-Na Zhang et al.
Asteraceae is a large class of eudicots with complex capitulum, and little is known regarding the molecular regulation mechanism of flower development. APETALA1(AP1) belongs to the MADS-box gene family and plays a key role in plant floral i...
CRISPR/Gal4BD-Cas donor adapting systems based on miniaturized Cas proteins for improved gene editing [0.03%]
基于小型化Cas蛋白的CRISPR/Gal4BD-Cas供体适应系统实现更高效的基因组编辑
Sen Yang,Bao-Xia Ma,Hong-Run Qian et al.
Sen Yang et al.
Targeted precise point editing and knock-in can be achieved by homology-directed repair(HDR) based gene editing strategies in mammalian cells. However, the inefficiency of HDR strategies seriously restricts their application in precision me...
Yan-Chun Bao,Cai-Xia Shi,Chuan-Qiang Zhang et al.
Yan-Chun Bao et al.
With the rapid growth of data driven by high-throughput sequencing technologies, genomics has entered an era characterized by big data, which presents significant challenges for traditional bioinformatics methods in handling complex data pa...
Progress on CRISPR-Cas gene editing technology in sheep production [0.03%]
CRISPR-Cas基因编辑技术在羊生产中的应用进展
Dong-Xia Pan,Hui Wang,Ben-Hai Xiong et al.
Dong-Xia Pan et al.
Gene editing is a kind of genetic engineering technology that can modify the genome. In recent years, with the rapid development of molecular biotechnology, the clustered regularly interspaced short palindromic repeats associated protein sy...
Min Yang,Si-Yuan Lin,Chang-Qi Yang et al.
Min Yang et al.
The sex determination in mammals refers to the development of an initial bipotential organ, termed the bipotential gonad/genital ridge, into either a testis or an ovary at the early stages of embryonic development, under the precise regulat...