Synthesis and biological evaluation of 2-benzylaminoquinazolin-4(3 H)-one derivatives as a potential treatment for SARS-CoV-2 [0.03%]
作为SARS-CoV-2潜在治疗药物的2-(苯基氨基)喹唑啉-4(3H)-one衍生物的合成及生物学评价
Jun Young Lee,Young Sup Shin,Sangeun Jeon et al.
Jun Young Lee et al.
Despite the continuing global crisis caused by coronavirus disease 2019 (COVID-19), there is still no effective treatment. Therefore, we designed and synthesized a novel series of 2-benzylaminoquinazolin-4(3H)-one derivatives and demonstrat...
Development of surface-enhanced Raman scattering-based immunoassay platforms using hollow Au nanostars for reliable SARS-CoV-2 diagnosis [0.03%]
开发基于空心金纳米星的表面增强拉曼散射免疫测定平台，以实现可靠的SARS-CoV-2诊断
Qian Yu,Yixuan Wu,Taejoon Kang et al.
Qian Yu et al.
We developed a novel surface-enhanced Raman scattering (SERS)-based SARS-CoV-2 assay platform using hollow Au nanostars to realize high-sensitivity diagnosis of SARS-CoV-2. The assay was performed using SARS-CoV-2 lysate as the target in a ...
New Synthetic Approach to the Bicyclo[3.1.0]hexane Ring System from (+)-(1 R,4 R)-4-(Benzyloxymethyl)-4-(hydroxymethyl)cyclopent-2-enol [0.03%]
从(+)-(1R,4R)-4-(苯甲氧基甲基)-4-(羟甲基)环戊-2-烯醇到新型合成双环[3.1.0]己烷环系统的方法
Soon-Ai Kim,Kenneth A Jacobson,Hak Sung Kim
Soon-Ai Kim
Study on the 2-Phenylchroman-4-One Derivatives and their anti-MERS-CoV Activities [0.03%]
2-苯基色满酮衍生物的抗MERS-CoV活性研究
Ji Hye Yoon,Jihye Lee,Jun Young Lee et al.
Ji Hye Yoon et al.
Study on the 2-phenylchroman-4-one derivatives and their anti-MERS-CoVactivities. Keywords: 2‐phenylchroman...
Selective Inhibition of Enzymatic Activities of Severe Acute Respiratory Syndrome Coronavirus Helicase with a Thioxopyrimidine Derivative [0.03%]
用于选择性抑制严重急性呼吸系统综合症冠状病毒解旋酶的酶活性的噻唑吡啶衍生物
Jin-Moo Lee,Jin-Beom Cho,Hee-Chul Ahn et al.
Jin-Moo Lee et al.
Keywords: ATP hydrolysis; DNA unwinding; Helicase; Inhibitor; Severe acute respiratory syndrome.
Synthesis and Binding Affinity of Homologated Adenosine Analogues as A3 Adenosine Receptor Ligands [0.03%]
同化腺苷类似物的合成及其与A3腺苷受体结合能力的研究
Hyuk Woo Lee,Won Jun Choi,Kenneth A Jacobson et al.
Hyuk Woo Lee et al.
Homologated analogues 3a and 3b of potent and selective A3 adenosine receptor ligands, IB-MECA and dimethyl-IB-MECA were synthesized from commercially available 1-O-acetyl-2,3,5-tri-O-benzoyl-β-d-ribofuranose (4) via Co2(CO)8-catalyzed sil...
Dosage Effects of Salt and pH Stresses on Saccharomyces cerevisiae as Monitored via Metabolites by Using Two Dimensional NMR Spectroscopy [0.03%]
二维核磁共振技术在监测不同浓度NaCl和pH胁迫下酿酒酵母代谢效应中的应用研究
Young Kee Chae,Seol Hyun Kim,James E Ellinger et al.
Young Kee Chae et al.
Saccharomyces cerevisiae, which is a common species of yeast, is by far the most extensively studied model of a eukaryote because although it is one of the simplest eukaryotes, its basic cellular processes resemble those of higher organisms...
Pump-Probe X-ray Solution Scattering Reveals Accelerated Folding of Cytochrome c Upon Suppression of Misligation [0.03%]
通过抑制误配体结合加速细胞色素c折叠的泵探针X射线溶液散射法研究
Tae Wu Kim,Jong Goo Kim,Cheolhee Yang et al.
Tae Wu Kim et al.
Tracing Metabolite Footsteps of Escherichia coli Along the Time Course of Recombinant Protein Expression by Two-Dimensional NMR Spectroscopy [0.03%]
二维核磁共振光谱法追踪大肠杆菌蛋白表达过程中代谢产物随时间的变化规律
Young Kee Chae,Seol Hyun Kim,James J Ellinger et al.
Young Kee Chae et al.
The recombinant expression of proteins has been the method of choice to meet the demands from proteomics and structural genomics studies. Despite its successful production of many heterologous proteins, Escherichia coli failed to produce ma...
Recombinant Expression, Isotope Labeling and Purification of the Vitamin D Receptor Binding Peptide [0.03%]
维生素D受体结合肽的重组表达、同位素标记及纯化
Young Kee Chae,Kiran Singarapu,W Milo Westler et al.
Young Kee Chae et al.
The vitamin D receptor binding peptide, VDRBP, was overexpressed as a fused form with the ubiquitin molecule in Rosetta(DE3)pLysS, a protein production strain of Escherichia coli harboring an induction controller plasmid. The fusion protein...