Brief guide to assays for measuring health parameters using Caenorhabditis elegans [0.03%]
利用秀丽隐杆线虫测量健康参数的检测简明指南
Seungjae Hwang,Jongsun Lee,Seung-Jae V Lee
Seungjae Hwang
Assessing health parameters is essential for understanding the decline of physiological functions during aging. The nematode Caenorhabditis elegans serves as a powerful model in aging research. This paper introduces representative methods f...
MicroRNA-196a increases apoptosis in B cells through downregulation of FOXO1 [0.03%]
微小核糖核酸-196a通过下调FOXO1增加B细胞凋亡
Soyoung Kim,Mina Han,Hyun Ju Hwang et al.
Soyoung Kim et al.
MicroRNAs (miRNAs) are key regulators of cancer pathogenesis, and their expression is often dysregulated in cancer cells. The role of miR-196a-5p has been investigated in various types of cancers, however it is relatively less understood in...
Effects of heterozygous SMG1 mutations on nonsense-mediated mRNA decay in human pluripotent stem cell model [0.03%]
SMG1杂合突变对人多能干细胞模型中无意义介导的mRNA降解的影响
Chanyoung Lee,Jin Sook Lee,Yejin Kwon et al.
Chanyoung Lee et al.
Nonsense-mediated mRNA decay (NMD) eliminates transcripts containing premature termination codons (PTCs), thereby preventing errors in protein synthesis. Serine/Threonine-protein kinase SMG1 is a crucial kinase for NMD response, interacting...
SimpleViz: A User-Friendly, Web-Based Tool for Publication-Ready Data Visualization in Bioinformatics [0.03%]
简单易用的基于Web的生物信息学出版物级数据展示工具 SimpleViz
Byeong Seob Oh,Juhee Kim,Minjeong Kwon et al.
Byeong Seob Oh et al.
Large-scale datasets are central to bioinformatics research, creating a demand for intuitive visualization tools that transform complex data into accessible graphics. Existing visualization software often comes with high costs or requires c...
Thilini Ranasinghe,Seon-Heui Cha
Thilini Ranasinghe
This work described simple methods for measuring locomotive activity using open-source software, ImageJ1.54fFiji and VirtualDub2. The significance of animal behavior is a mirror of brain activity, which can give information implicated with ...
Intestinal bacteria-derived extracellular vesicles in metabolic dysfunction-associated steatotic liver disease: from mechanisms to therapeutics [0.03%]
肠道菌群源性细胞外囊泡在代谢功能障碍相关性脂肪型肝病中的作用机制及治疗潜力
Li-Na Qin,Yun-Feng Yu,Lie Ma et al.
Li-Na Qin et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disease that affects the health of approximately one-third of the world's population. It is the primary cause of end-stage liver disease, liver malignancy, an...
Decoding SPP1 regulation: genetic and non-genetic insights into its role in disease progression [0.03%]
解码SPP1的调控：其在疾病进展中的作用的遗传和非遗传见解
Sungju Jung,Jiseon Ha,Jong Hoon Park et al.
Sungju Jung et al.
Secreted phosphoprotein 1 (SPP1), also known as osteopontin (OPN), is a multifunctional glycoprotein that plays a critical role in various physiological processes, including cell adhesion, chemotaxis, immune regulation, and tissue remodelin...
Phosphorylation of eIF2α suppresses the impairment of GSH/NADPH homeostasis and mitigates the activation of cell death pathways, including ferroptosis, during ER stress [0.03%]
eIF2α的磷酸化抑制GSH/NADPH平衡的损伤并在ER压力期间缓解细胞死亡途径，包括铁死亡，的激活
Hien Thi Le,Yong Hwan Kim,Mi-Jeong Kim et al.
Hien Thi Le et al.
eIF2α phosphorylation helps maintain cellular homeostasis and overcome endoplasmic reticulum (ER) stress through transcriptional and translational reprogramming. This study aims to elucidate the transcriptional regulation of glutathione (G...
Cholesterol Sulfate as a Negative Regulator of Cellular Cholesterol Homeostasis [0.03%]
胆固醇硫酸盐作为细胞胆固醇稳态的负调控因子
Le Ba Nam,Sung-Jin Kim,Tan Khanh Nguyen et al.
Le Ba Nam et al.
Cholesterol sulfate (CS), one of the most abundant cholesterol derivatives, recently emerged as a key regulatory molecule in several physiological processes. Here, we demonstrate multiple mechanisms by which CS reduces intracellular cholest...
Protein-O-fucosylation of co-receptors may be required for Nodal signaling in Xenopus [0.03%]
非洲爪蟾中Nodal信号可能需要共受体的O-岩藻糖基化修饰
Yeon-Jin Kim,Seung-Joo Nho,Soo Young Lee et al.
Yeon-Jin Kim et al.
Nodal-related ligands of TGF-β family play pivotal roles for mesoderm induction and body axis formation during vertebrate early embryogenesis. Nodal ligands are distinct from most other TGF-β ligands family as they require EGF-CFC factors...