Seongjun Kim,Hye Jin Cho,I-Hao Wang et al.
Seongjun Kim et al.
The precise assembly of neural circuits is a marvel of cellular engineering, requiring the seamless coordination of long-range axon navigation and short-range synapse formation. Traditionally, these two processes were thought to be governed...
Chan Hoon Jung,Hyeonseong Kang,Yusung Park et al.
Chan Hoon Jung et al.
Drosophila melanogaster is a powerful genetic model organism due to its short life cycle, simple husbandry, and versatile genetic toolkit. Reliable experimental outcomes, however, depend on standardized husbandry and stock maintenance pract...
Katsuhiko Tabuhi,Emi Kouyama-Suzuki,Toru Yanagawa et al.
Katsuhiko Tabuhi et al.
Calcium/calmodulin-dependent serine protein kinase (CASK) is an X-linked multidomain scaffolding protein originally identified as an intracellular binding partner for Neurexins, a family of presynaptic cell-adhesion molecules. Loss-of-funct...
Virus-induced genome editing enables functional genomics across diverse plant species [0.03%]
病毒诱导的基因组编辑可在多种植物物种中实现功能基因组学
Eunae Park,Sunghee Lee,Dongha Kim et al.
Eunae Park et al.
Virus-induced genome editing (VIGE) is expanding plant functional genomics by enabling precise and heritable genome modification across diverse species. While classical model systems such as Arabidopsis thaliana have provided foundational g...
Artificial Intelligence and Multi-Omics Integration for Parkinson's Disease Drug Development [0.03%]
人工智能与多组学整合在帕金森病药物研发中的应用
Seulah Lee,Jaehoon Kim,Hae-Un Jung et al.
Seulah Lee et al.
Recent advances underscore the potential of integrating multi-omics, such as genomics, transcriptomics, proteomics, and metabolomics, and artificial intelligence to overcome limitations regarding early diagnosis and treatment of Parkinson's...
Yejin Hwang,Seung-Jae V Lee
Yejin Hwang
In this editorial, we provide an integrative overview of MiniResource papers published in Molecules and Cells in 2024 and 2025, which establish reliable methodological practices across various fields in molecular and cellular biology. By em...
Victoria N Chang,Roberto Ogelman,Raul Satoshi Vargas et al.
Victoria N Chang et al.
Excitatory synapse plasticity at postsynaptic dendritic spines is directly modulated through neurotransmitter signaling. Serotonin (5-HT) is a primary neuromodulator in the brain that activates 14 subtypes of G-protein-coupled receptors, ea...
Workflows for Stable Cell Line Generation: Chemical Transfection and Viral Transduction [0.03%]
适用于稳定细胞系构建的实验方案：化学转染和病毒感染
Chanhyuk Min,Jongsik Kim,Gwangrog Lee
Chanhyuk Min
Stable mammalian cell lines with sustained transgene expression are indispensable for functional genomics and long-term genetic studies. However, transient approaches often suffer from inconsistent efficiency and expression instability acro...
CpG oligodeoxynucleotide reduces PrPSc accumulation and prolongs survival in prion-infected mice [0.03%]
CpG寡核苷酸减少prion感染小鼠PrPSc的积累并延长其生存期
Mohd Najib Mostafa,Byungki Jang,Mo-Jong Kim et al.
Mohd Najib Mostafa et al.
Prion diseases, also known as transmissible spongiform encephalopathies, are characterized by the accumulation of misfolded prion proteins (PrPSc), which resists clearance due to impaired removal mechanisms and immune tolerance. Although st...
Molecular role of DRG1 in coordinating osteoclast and osteoblast differentiation during bone remodeling [0.03%]
DRG1在骨重建过程中协调破骨细胞和成骨细胞分化的分子作用
Jung Ha Kim,Semun Seong,Kabsun Kim et al.
Jung Ha Kim et al.
The developmentally regulated GTP-binding protein (DRG) family, comprising DRG1 and DRG2, plays pivotal roles in cellular differentiation. While DRG2 has been recognized as a key regulator of bone homeostasis, the biological significance of...