In Memoriam: Dr. Wan-Kyu Cho, Pioneer of Developmental Biology and Architect of Korean Science [0.03%]
沉痛悼念郑万규博士——发育生物学的先驱和韩国科学的建筑师
Min Whan Jung
Min Whan Jung
USP15 mutation associated with autism spectrum disorder alters progenitor fate and neuronal maturation in human brain organoids [0.03%]
USP15基因突变与自闭症谱系障碍相关并改变人脑类器官前体细胞命运和神经元成熟度
Tae-Hwan Park,In Gyeong Koh,Seoyoung Sung et al.
Tae-Hwan Park et al.
De novo variants in the ubiquitin-proteasome pathway are linked to autism spectrum disorder (ASD), yet their functional impact on neurodevelopment remains poorly understood. We investigated USP15, a deubiquitinating enzyme with rare damagin...
Oxidative Stress Drives Liver Failure During In Vivo Partial Reprogramming [0.03%]
氧化应激在体内部分重编程过程中驱动肝衰竭
Hee-Ji Eom,Beom-Ki Jo,Jumee Kim et al.
Hee-Ji Eom et al.
In vivo reprogramming using the Yamanaka factors (OCT4, SOX2, KLF4, and c-MYC; OSKM) enables tissue regeneration but raises major safety concerns when factor expression is sustained. Here, using a doxycycline-inducible OSKM mouse model, we ...
scpp5 Regulates Tooth Development and Injury-Induced Repair in Zebrafish through Mineralization and Wnt/β-Catenin Signaling [0.03%]
斑马鱼SCPP5通过矿化和Wnt/β-catenin信号通路调控牙齿发育和损伤修复
Qiqi Liu,Weifeng Hao,Zhenan Zhang et al.
Qiqi Liu et al.
A member of the secretory calcium-binding phosphoprotein (SCPP) family, scpp5 is specifically expressed in zebrafish tooth germ. Although preliminary data indicates that scpp5 deficiency impairs tooth mineralization, its molecular mechanism...
Corrigendum to "Molecular role of developmentally regulated GTP-binding protein 1 in coordinating osteoclast and osteoblast differentiation during bone remodeling" [Mol. Cells 49 (2026) 100342] [0.03%]
关于“发育相关GTP结合蛋白1在骨重建过程中协调破骨细胞和成骨细胞分化中的分子作用”的勘误[Mol. Cells 49 (2026) 100342]
Jung Ha Kim,Semun Seong,Kabsun Kim et al.
Jung Ha Kim et al.
Published Erratum
Molecules and cells. 2026 May 26;49(7):100370. DOI:10.1016/j.mocell.2026.100370 2026
Multiple ShKT domain-containing MUL-1 proteins act as redox-responsive modulators of oxidative stress signaling in C. elegans [0.03%]
多SHKT结构域的MUL-1蛋白作为C. elegans氧化应激信号的红氧响应调节因子
Emilio Carranza-Garcia,Abe Gayle Santos,Kyoung-Hye Yoon et al.
Emilio Carranza-Garcia et al.
Organismal survival depends on coordinated responses to oxidative stress and DNA damage. Using Caenorhabditis elegans, we investigate mul-1, a robust transcriptional target of ionizing radiation and reactive oxygen species. Although annotat...
Small Molecule Inhibition of VDAC1 Reroutes Mitochondrial Metabolite Flux [0.03%]
小分子抑制VDAC1重新导向线粒体代谢物通量
Seyed Majed Modaresi,Leilei Zhang,Amir Ata Saei et al.
Seyed Majed Modaresi et al.
Voltage dependent anion channels (VDACs 1, 2 and 3) in the outer mitochondrial membrane control the flux of anions and oxidizable substrates that sustain mitochondrial metabolism. NADH closes VDAC by binding to a pocket, conserved in all is...
Adherent-to-suspension transition modulates circulating tumor cell dynamics and metastatic potential in melanoma [0.03%]
黑色素瘤中附着到悬浮转变调节循环肿瘤细胞动态和转移潜能
Dong Ki Lee,Jongwook Oh,Soyeon Lee et al.
Dong Ki Lee et al.
Melanoma metastasis involves dynamic cellular reprogramming that enables tumor cells to survive detachment and disseminate to distant organs. We investigated the role of adherent-to-suspension transition (AST) in melanoma metastasis, examin...
Mitochondrial calcium modulates odor-mediated behavioral plasticity in C. elegans [0.03%]
线粒体钙离子调控秀丽隐杆线虫的气味介导的行为可塑性
Hee Kyung Lee,Abe Gayle Santos,Kyu-Sang Park et al.
Hee Kyung Lee et al.
Despite growing understanding of the various roles mitochondria play in neurons, how they contribute to higher brain functions such as learning and memory remains underexplored. Here, using the nematode Caenorhabditis elegans, we found that...
The 40% weight-reduction craze: market volatility, metabolic nuance, and the quest for sustainable health [0.03%]
40%减重风潮：市场波动、代谢细微差别与追求可持续健康之路
Weiping Han,Peter Shepherd,Kohjiro Ueki et al.
Weiping Han et al.
The pharmaceutical industry is currently engaged in an intense competition to maximize weight reduction percentages. The evolution from standard glucagon-like peptide-1 (GLP-1) receptor agonists to dual and triple agonists and even more com...