Tae Young Kim,Byoung Dae Lee
Tae Young Kim
Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of misfolded α-synuclein. Current treatments, including dopaminergic medications and deep brain sti...
Identification and application of promoters and terminators for plant synthetic biology [0.03%]
植物合成生物学的启动子和终止子的鉴定与应用
Hyunjin Koo,Minah Jung,Sangwoo Lee et al.
Hyunjin Koo et al.
Plant synthetic biology is an emerging field that combines bioinformatics, computational gene circuit design, and plant science. It has the potential to be applied in various areas, including the production of pharmaceuticals, vaccines, bio...
Decoding Genomic Rearrangements in Cancer: Path to Novel Driver Discovery [0.03%]
解析癌症中的基因组重排：发现新型驱动因子之路
Enyoung Seo,Sooyeon Park,Inho Park et al.
Enyoung Seo et al.
Somatically acquired genomic rearrangements are common genomic alterations that contribute to malignancy by altering the expression or activity of cancer-related genes in human cancer. Genomic rearrangements play a crucial role in tumor dev...
The nutrient sensing for whole-body homeostasis: beyond the cellular level [0.03%]
营养感应与全身稳态：细胞水平之外的故事
Gahbien Lee,Jiyeon Lee,Greg S B Suh et al.
Gahbien Lee et al.
Systemic nutrient sensing is a fundamental process that aligns nutrient availability with an organism's metabolic demands. This mini-review explores nutrient sensors in the intestine, pancreas, portal vein, and the brain-organs that detect ...
Rationale and Emerging Evidence for Microglial Replacement in Alzheimer's Disease [0.03%]
阿尔茨海默病中微胶质细胞替代的理论依据和新兴证据
Jee Yoon Bang,Yongjin Yoo
Jee Yoon Bang
Microglial biology in Alzheimer's disease (AD) has become a major focus of investigation, aiming to define how these cells contribute to neurodegeneration and to develop new therapeutic strategies. Once regarded as passive responders, micro...
Iron Metabolism Dysregulation and Ferroptosis: Emerging Drivers in Pulmonary Fibrosis Pathogenesis and Therapy [0.03%]
铁代谢失调与铁依赖性细胞死亡在肺纤维化发生发展中的作用及治疗潜力
Yawen Jiang,Ligang Zhang,Yuandong Lin et al.
Yawen Jiang et al.
Ferroptosis is an iron-dependent and regulated form of cell death, characterized by lipid peroxidation and oxidative stress. The progressive development of pulmonary fibrosis (PF) is closely linked to the ferroptosis pathway. Although the u...
Identification of a Unique Subpopulation of Mucosal Fibroblasts in Colorectal Cancer with Tumor-Restraining Characteristics [0.03%]
识别具有抗肿瘤特性的结直肠癌黏膜成纤维细胞独特亚群
Jamin Ku,Eunjin Jeong,Jeong-Ryeol Gong et al.
Jamin Ku et al.
While Tumor-restraining cancer-associated fibroblasts (Tr-CAFs) have been investigated in various cancers, their existence in colorectal cancer remains unexplored. We performed a comprehensive analysis of diverse colorectal cancer datasets,...
Multifaceted role of serine hydroxymethyltransferase in health and disease [0.03%]
丝氨酸羟甲基转移酶在健康和疾病中的作用
Jing Zhang,Seong Eun Lee,Ji Yeon Yoon et al.
Jing Zhang et al.
Serine hydroxymethyltransferase (SHMT) is a key enzyme in one-carbon metabolism (OCM), a biochemical pathway critical for cellular growth, proliferation, and survival. OCM integrates the folate and methionine cycles to produce essential int...
Role of expression quantitative trait loci (eQTL) in understanding genetic mechanisms underlying common complex diseases [0.03%]
表达定量性状位点（eQTL）在阐明复杂疾病遗传机制中的作用
Sung Eun Hong,Murim Choi,Jeongha Lee
Sung Eun Hong
Attaining a complete understanding of the genetic architecture underlying common complex traits is challenging due to the substantial contributions of non-genetic factors and the involvement of numerous influencing genes. Genome-wide associ...
Junsoo Oh,Yeseul Park,Shinae Park et al.
Junsoo Oh et al.
Protein phosphatase 2A-B56 (PP2A-B56) is a key regulator of mitosis, playing an essential role in maintaining chromosomal stability and ensuring the fidelity of cell division. As a component of the PP2A holoenzyme, the B56 regulatory subuni...