Dajeong Bong,Hyunwoo C Kwon,Seung-Jae V Lee
Dajeong Bong
Aging in Caenorhabditis elegans is regulated by evolutionarily conserved pathways that coordinate cellular maintenance and systemic homeostasis. Here, we review recent advances on four major longevity regimens including reduced insulin/insu...
Jiwon Choi,Geert De Jaeger,Hoo Sun Chung
Jiwon Choi
Cytokinesis, the final stage of cell division, physically partitions cytoplasm between daughter cells through mechanisms evolved to accommodate unique cellular constraints. Plant cells divide by the formation of rigid cell walls using the p...
Set1-dependent H3K4 methylation is essential for sustained gene expression at newly activated loci [0.03%]
组蛋白H3赖氨酸4甲基化对于新转录起始位点上基因表达的维持是必需的
Shinae Park,Kyungmin Lee,Junsoo Oh et al.
Shinae Park et al.
Histone H3 lysine 4 trimethylation (H3K4me3) has been associated with active transcription, yet whether it plays a causative role in gene activation remains an open question. In this study, we reveal that the deletion of Paf1 complex subuni...
Seok Chan Cho,Hyun Woo Park
Seok Chan Cho
Protein-protein interactions (PPIs) are central to all cellular processes and play critical roles in both normal physiology and disease pathogenesis. In this brief guide, we outline the fundamental principles and widely used methods for PPI...
RE-Aging, A Functional Analysis Platform for Human RNA Editing Associated with Aging [0.03%]
RE-Aging，与人类衰老相关的RNA编辑功能分析平台
Xinyu Pan,Hui Zhang,Weiwen Huang et al.
Xinyu Pan et al.
RNA editing alters mRNA sequences and is linked to aging. We introduce RE-Aging, a platform analyzing age-related RNA editing using GTEx data (259,620 A-to-I and 30,502 C-to-U sites across 27 tissues). Features include site exploration, age...
THRAISE: An Automated and Reproducible Web Platform for RNA-seq Analysis [0.03%]
基于Web的自动化和可重复RNA序列分析平台THRAISE
Hyeon Ho Heo,Soo-Jong Um
Hyeon Ho Heo
THRAISE (Transcriptome-wide High-throughput RNA-seq Analysis Integrated System) is a highly streamlined web platform for RNA-seq analysis that requires no programming expertise. Starting from raw NCBI SRA data, it performs the entire analys...
Deficient chaperone-mediated autophagy in macrophages aggravates colitis and colitis-associated tumorigenesis in mice [0.03%]
小鼠巨噬细胞中自噬功能缺陷加重结肠炎和相关肿瘤发生
Weichun Zhu,Zehao Chen,Yunqian Gao et al.
Weichun Zhu et al.
Chaperone-mediated autophagy (CMA) is a highly selective form of autophagy re-sponsible for the degradation of specific cytosolic proteins within lysosomes. Recent research has established a significant correlation between CMA and colorecta...
Seokjun G Ha,Ji-Hoon Park,Mi-Young Kim et al.
Seokjun G Ha et al.
Western blot is an essential method that detects specific proteins using antibodies, which is one of the most widely applied techniques for protein detection. Here, we present a brief guide to western blot, following the overall procedure f...
Ionotropic receptors mediate arachidic acid perception and food avoidance behavior in Drosophila melanogaster [0.03%]
硬脂酸感受器介导果蝇对有害食物的规避行为
Roshani Nhuchhen Pradhan,Muhammad Atif,Youngseok Lee
Roshani Nhuchhen Pradhan
Chemosensory functions are essential for animals to distinguish between nutritious and harmful compounds. Fatty acids are vital dietary components, but their taste perception mechanisms remain poorly understood. In Drosophila melanogaster, ...
Ravi Shankar Goutam,Neha Kaushik,Basant Kumar et al.
Ravi Shankar Goutam et al.
The Iroquois (Iro/Irx) gene family encodes transcription factors that belong to the TALE-class homeodomain group, distinguished by a conserved Iro-box domain. Iroquois signaling is evolutionarily conserved from invertebrates to vertebrates ...