Krishan Maggon
Krishan Maggon
This is the story of my quest to jump-start new drug development activities in India at the custom synthesis, animal models, bulk drug production, toxicology and preclinical stages. A snapshot of research and evaluation during the 1995-1999...
Bikash Debnath,Laith Q Al-Mawsawi,Nouri Neamati
Bikash Debnath
For the last two decades, we have seen remarkable growth in the pharmaceutical industry. This growth has mainly been due to the approximately 100 new blockbuster drugs, such as Lipitor® (atorvastatin) and Plavix® (clopidogrel). More than ...
Epigenetic alterations of tumor marker microRNAs: towards new cancer therapies [0.03%]
肿瘤标志microRNA表观遗传改变：面向新的癌症治疗方法
Jia Wei,Li Xie,Miquel Taron et al.
Jia Wei et al.
MicroRNAs (miRNAs) are a class of short noncoding RNAs that participate in mastering the balance of gene-regulating networks. By targeting and controlling expression of messenger RNA, miRNAs can control highly complex signal transduction pa...
Electroporation: a promising method for the nonviral delivery of DNA vaccines in humans? [0.03%]
电穿孔：人类非病毒递送DNA疫苗的前景方法？
Lars Frelin,Anette Brass,Gustaf Ahlén et al.
Lars Frelin et al.
The without a doubt major obstacle for making DNA vaccines a commercial success is delivery. If delivery cannot be made simple, cheap and effective, DNA vaccines may not become a viable option for human use. Numerous clinical trials have co...
Shikha S Chauhan,Moni Sharma,Prem M S Chauhan
Shikha S Chauhan
Artemisinin, with its 1,2,4-trioxane as active motif, is now the first-line treatment for multidrug-resistant malaria. The endoperoxide ring is essential for the antimalarial activity of artemisinin. Based on its mechanism of action, new hy...
Inhibition of potassium currents as a pharmacologic target for investigation in chronic lymphocytic leukemia [0.03%]
钾电流抑制作为慢性淋巴细胞白血病研究的药理学靶点
Bella Biderman,Andrey Marakhonov,Mikhail Skoblov et al.
Bella Biderman et al.
Chronic lymphocytic leukemia (CLL) represents 22-30% of all leukemia cases, thus being the most commonly diagnosed form of adult leukemia in the Western world. On a cellular level, the disease progresses due to the prolonged survival of B-c...
Rainer Kalscheuer,William R Jacobs Jr
Rainer Kalscheuer
Largely neglected by the industrialized world for decades, tuberculosis (TB), caused by the bacterium Mycobacterium tuberculosis, has made a fulminant return to the public health agenda as a major global health threat. The worsening of the ...
Financial conflicts of interest in biomedical research: the need to improve the system [0.03%]
生物医学研究中的财务利益冲突：改善体系的必要性
Amy T Wang,Victor M Montori,Mohammad Hassan Murad
Amy T Wang
Fifty years ago, the issue of conflict of interest in biomedical research appeared in the national spotlight and has remained in a state of constant evolution. Government legislation caused a boom in collaborations between physicians, resea...