NF45 and NF90 in murine seminiferous epithelium: potential role in SP-10 gene transcription [0.03%]
NRF45和NRF90在小鼠生精小管上皮中的作用及对SP-10基因转录的潜在影响
Sandeep A Ranpura,Umesh Deshmukh,Prabhakara P Reddi
Sandeep A Ranpura
Identification of transcription factors involved in the progression of spermatogenic cell differentiation is important for understanding the molecular mechanisms controlling spermatogenesis. To this end, we utilized the mouse SP-10 gene enc...
Molecular pharmacotherapeutic targeting of PDE5 for preservation of penile health [0.03%]
PDE5分子药理靶向在阴茎健康保护中的作用
Arthur L Burnett
Arthur L Burnett
The molecular science of erection physiology has established that phosphodiesterase 5 (PDE5) serves an important biological role in the penis. Current research in the field has revealed this molecular effector to be relevant for penile erec...
A dose-response study of testosterone on sexual dysfunction and features of the metabolic syndrome using testosterone gel and parenteral testosterone undecanoate [0.03%]
一项采用睾丸素凝胶和十四烷酸睾酮的剂量反应研究：对性功能障碍及代谢综合征特征的影响
Farid Saad,Louis J Gooren,Ahmad Haider et al.
Farid Saad et al.
The objective of this study was to observe the dose-response effects of testosterone (T) treatment on symptoms of sexual dysfunction and the metabolic syndrome. Two cohorts of elderly men with late-onset hypogonadism were followed over 9 mo...
Clinical Trial
Journal of andrology. 2008 Jan-Feb;29(1):102-5. DOI:10.2164/jandrol.107.002774 2008
Morphology and meiotic segregation in spermatozoa from men of proven fertility [0.03%]
精子形态和生育力男性的精子减数分裂分离现象
Giulia Collodel,Elena Moretti
Giulia Collodel
Estimates of semen parameters are important for defining normal ranges, which are currently established by 1999 World Health Organization guidelines. However, it is well known that semen evaluation is questionable because it is necessary fo...
Downregulation of thymosin beta4 expression by androgen in prostate cancer LNCaP cells [0.03%]
雄激素下调前列腺癌LNCaP细胞中胸腺素β4的表达
Kazuhiro Iguchi,Mai Ito,Shigeyuki Usui et al.
Kazuhiro Iguchi et al.
Androgen ablation therapy is an effective treatment for advanced prostate cancer, but the tumor often progresses toward a more aggressive phenotype. We determined the changes in genes associated with the malignant progression and found incr...
Wendie A Robbins,Fusheng Wei,David A Elashoff et al.
Wendie A Robbins et al.
Several epidemiologic investigations have shown shifts in sex ratios at birth toward females in populations with relatively high boron exposure. To investigate the paternal origin of these shifts, we assayed sperm Y:X ratio in men exposed t...
The clinical implementation of sperm chromosome aneuploidy testing: pitfalls and promises [0.03%]
精子染色体非整倍体检测的临床实施：挑战与前景
Douglas T Carrell
Douglas T Carrell
Severe male infertility has been shown to be associated with improper meiotic recombination and elevated sperm chromosome aneuploidy. Elevated sperm aneuploidy increases the risk of embryo lethality or fetal anomalies. Although difficulties...
Expression and distribution of laminin chains in the testis for patients with azoospermia [0.03%]
无精子症患者睾丸Ⅳ型胶原的表达及分布
Takeshi Ooba,Tomomoto Ishikawa,Kohei Yamaguchi et al.
Takeshi Ooba et al.
The aim of our study was to investigate the relationships between the expression of laminin in the testis and spermatogenesis, and the basement membrane (BM) of testicular tubules in fertile and infertile men. Testicular tissue samples were...
Proinflammatory cytokines as an intermediate factor enhancing lipid sperm membrane peroxidation in in vitro conditions [0.03%]
细胞因子作为体外增强脂质精子膜过氧化的中间因素
Monika Fraczek,Dorota Sanocka,Marzena Kamieniczna et al.
Monika Fraczek et al.
We have examined the effect of white blood cells (WBCs), various proinflammatory cytokines, or a combination of the two on the peroxidation of human sperm membrane lipids in in vitro conditions. Six recombinant cytokines, such as interleuki...
Higher sperm DNA damage in semen from men with spinal cord injuries compared with controls [0.03%]
脊髓损伤男性精子DNA损伤高于正常对照者
Nancy L Brackett,Emad Ibrahim,Jason A Grotas et al.
Nancy L Brackett et al.
Semen from men with spinal cord injuries (SCI) and control subjects was investigated for sperm DNA damage using the sperm chromatin structure assay. Three experiments were performed. In experiment 1, the DNA fragmentation index (DFI) was co...