Novel and Proven Models of Public, Private, and Public-Private Partnerships in Healthcare: An Update [0.03%]
新型和经过验证的医疗卫生公共、私营和公私合作模式：更新版
Heike A Wieland,Jochen Maas
Heike A Wieland
Initiatives to share assets in the life science sector through dedicated partnerships had and still have a multitude of different aspects in the past few decades. The range goes from industry partners, small and big companies, in bilateral ...
Iris Valtingojer,Sasha Lièvre,Philippe Bordes et al.
Iris Valtingojer et al.
The outcome for children with cancer has improved significantly over the past 60 years, with more than 80% of patients today becoming 5-year survivors. Despite this progress, cancer remains the leading cause of death from disease in childre...
The Alliance Between the German Cancer Research Center and Bayer: A Retrospective of an Innovative Collaboration Model [0.03%]
德国癌症研究中心与拜耳的合作联盟：创新型合作模式的回顾性分析
A Zuccotti,R Carretero,H Hess-Stumpp
A Zuccotti
In 2009, the German Cancer Research Center (DKFZ) and the biopharmaceutical company Bayer AG initiated an academic-industry co-discovery collaboration. The partners combined their expertise in tumor biology and drug discovery to identify an...
Life Science Incubation at LabCentral/BioLabs with Partners Extending from the USA to Europe [0.03%]
美国与欧洲合作伙伴共同支持的生命科学孵化器——以LabCentral和BioLabs为例
Johannes Fruehauf
Johannes Fruehauf
This chapter provides a blueprint for accelerating biotech and life sciences innovation using public-private partnerships to create innovation infrastructure that become a platform for scientific breakthroughs and economic growth. Examples ...
Peter Hein,Martin C Michel
Peter Hein
Project-based collaborations between a single academic group and a single pharmaceutical company arguably are the most frequent form of public-private partnership in preclinical research and development of new drugs. This chapter discusses ...
Adrenoceptors: Receptors, Ligands and Their Clinical Uses, Molecular Pharmacology and Assays [0.03%]
肾上腺受体：作用机制及其临床应用、分子药理及检测方法
Jillian G Baker,Roger J Summers
Jillian G Baker
The nine G protein-coupled adrenoceptor subtypes are where the endogenous catecholamines adrenaline and noradrenaline interact with cells. Since they are important therapeutic targets, over a century of effort has been put into developing d...
Spoorthy Kulkarni,Ian B Wilkinson
Spoorthy Kulkarni
Hypertension is a very prevalent condition associated with high mortality and morbidity, secondary to changes resulting in blood vessels and resultant end-organ damage. Haemodynamic changes, including an initial rise in cardiac output follo...
Haneen Dwaib,Martin C Michel
Haneen Dwaib
The sympathetic nervous system plays an important role in the regulation of endocrine pancreatic function, most importantly insulin release. Among the nine adrenoceptor (AR) subtypes, the α2A-AR appears to be the subtype most abundantly ex...
Roles of β-adrenoceptor Subtypes and Therapeutics in Human Cardiovascular Disease: Heart Failure, Tachyarrhythmias and Other Cardiovascular Disorders [0.03%]
β肾上腺素能受体亚型及药物在人类心血管疾病中的作用：心力衰竭、快速性心律失常及其他心血管病态
Yee Weng Wong,Haris Haqqani,Peter Molenaar
Yee Weng Wong
β-Adrenoceptors (β-ARs) provide an important therapeutic target for the treatment of cardiovascular disease. Three β-ARs, β1-AR, β2-AR, β3-AR are localized to the human heart. Activation of β1-AR and β2-ARs increases heart rate, for...
Martin C Michel
Martin C Michel
This chapter provides a short history of adrenoceptor research starting from the initial discovery of adrenaline. It covers the evolving classification of adrenoceptor subtypes, the cloning of these subtypes from multiple species, and facto...