Sandra M Rojas-Montoya,Mario E Cuevas-Galindo,Mónica Farfán-Paredes et al.
Sandra M Rojas-Montoya et al.
BODIPY and aza-BODIPY fluorophores have attracted considerable attention in theragnostic research because of their excellent photophysical properties, high photostability, structural versatility, and ease of chemical functionalization. Thes...
Billy Vuong,Nitesh Sanghai,Muhammad Shaharyar Khan Afridi et al.
Billy Vuong et al.
Boron has emerged as a versatile element in medicinal chemistry because its empty p-orbital enables reversible covalent interactions with biologically important nucleophiles while supporting diverse, tunable molecular architectures. Followi...
Icosahedral Boron Clusters as Platforms for Biomedical Applications: From Cellular Bioimaging to In Vivo Theranostics [0.03%]
用于生物医学应用的二十面体硼簇：从细胞生物成像到活体诊疗学
Javier Ordóñez-Hernández,Rosario Núñez
Javier Ordóñez-Hernández
Icosahedral boron clusters have gained increasing attention as biomedical platforms for integrated imaging and therapy. Their outstanding chemical and metabolic stability, high boron density, and structural adaptability enable the design of...
Igor B Sivaev
Igor B Sivaev
The first quarter of the twenty-first century has seen a rapid expansion of research into the medical applications of boron cluster-based compounds. Key areas of this research include the use of polyhedral boron hydrides (carboranes, borane...
Boron Clusters for Potential Glioblastoma Therapy: Emerging Molecular and Nanostructured Strategies [0.03%]
用于胶质母细胞瘤治疗的硼簇：新兴分子和纳米结构策略
Marcos Couto
Marcos Couto
Glioblastoma remains among the most aggressive and treatment-refractory brain tumors, prompting the exploration of alternative therapeutic strategies. Boron clusters including carboranes, metallacarboranes, and dodecaborate-based systems ha...
Physiology of Kidney Glucose Transport and Mechanisms of Kidney Protection by SGLT2 Inhibitors [0.03%]
肾脏葡萄糖转运生理及SGLT2抑制剂肾保护机制
Volker Vallon
Volker Vallon
The Na+-coupled glucose transporter SGLT2 is expressed in the early proximal tubule of the kidney, where it reabsorbs most of the filtered glucose. Drugs that inhibit SGLT2 (SGLT2i) can protect the kidneys in patients with and without type ...
TAAR Immunopharmacology [0.03%]
TAAR免疫药理学
Anna Magnesa,Andrea Pacini,Grazia Rutigliano
Anna Magnesa
Trace amine-associated receptors (TAARs) were originally identified as G protein-coupled receptors involved in monoaminergic signaling within the central nervous system. However, accumulating evidence indicates that TAARs, particularly TAAR...
Ziqi Gu,De-Nong Liu,Yun-Ai Su
Ziqi Gu
Substantial evidence indicates that stress serves as a major risk factor for various psychiatric disorders, including major depressive disorder (MDD), anxiety disorders, post-traumatic stress disorder (PTSD), and bipolar disorder. Although ...
Beyond Glucose Thresholds: Nutrition, Glycaemic Dynamics and Vascular Dysfunction in Gestational Diabetes Mellitus [0.03%]
超越血糖阈值：妊娠糖尿病的营养、糖代谢动力学和血管功能障碍
Paola Valero,Sarah Maria Barneze Costa,Marilza Vieira Cunha Rudge et al.
Paola Valero et al.
Gestational diabetes mellitus (GDM) is increasingly diagnosed in women strongly driven by the increase in overweight and obesity in women of childbearing age, yet the literature still addresses this condition more often through the lens of ...
Lesha Pretorius,Carine Smith
Lesha Pretorius
Most TAAR-related drug discovery research which has advanced to clinical trials has focused on neuropsychiatric disease. Unfortunately, most studies are either conducted on males only or male and female data are not presented separately to ...