J Gustavo Vázquez-Jiménez,Tatiana Romero-García
J Gustavo Vázquez-Jiménez
The significant concern about the incidence and prevalence of cardiometabolic disorders around the world continues to rise as this upward trend persists. As researchers intensify their search for underlying causes, there is a growing demand...
In Search of a Biomarker for Vasculopathy Associated with Metabolic Syndrome [0.03%]
寻找与代谢综合征相关的血管病生物标志物之旅
Donjuán-Loredo Guadalupe,Saavedra-Serrato Luis,Chávez-Morales Tómas et al.
Donjuán-Loredo Guadalupe et al.
Central obesity is associated with a group of metabolic and cardiovascular alterations known as metabolic syndrome (MetS). MetS affects an estimated 20-25% of the global population. The clinical diagnosis of MetS is made using different met...
Are the Direct Oral Anticoagulants Better Than Warfarin for the Prevention and Treatment of Stroke and Atrial Fibrillation? [0.03%]
直接口服抗凝药物较华法林更有优势用于预防和治疗卒中及相关房颤吗？
Vittorio Pengo,Francesco Marongiu,Doris Barcellona
Vittorio Pengo
Atrial fibrillation is the most common cardiac arrhythmia in adults, affecting approximately 59.7 million people worldwide as of 2019-a 111% increase since 1990. Over the past 20 years, the prevalence of AF has risen by 33%, and it is proje...
Antiplatelet Therapy [0.03%]
抗血小板治疗
Richard T Amison,Simon C Pitchford
Richard T Amison
Platelets are a crucial component in the maintenance of normal haemostasis. In response to vascular damage, activated platelets adhere to the damaged endothelium leading to both aggregation and coagulation. Under healthy conditions, these p...
Laboratory and Point of Care Monitoring of Vitamin K Antagonist Treatment [0.03%]
维生素K拮抗剂治疗的实验室和即时检测监护
Ian Jennings,Dianne Kitchen
Ian Jennings
Vitamin K antagonist (VKA) therapy is given to patients either after a thrombosis or prophylactically to prevent a thrombotic event. VKAs block the action of vitamin K reductase which converts inactive forms of Factors II, FVII, FIX, FX, pr...
Antonia Katsouda,Andreas Papapetropoulos
Antonia Katsouda
Over the past several decades, sulfide has emerged as an important signaling molecule, playing diverse physiological and pathological roles across a broad spectrum of human health conditions. Among its recently recognized systemic effects, ...
Alice Y Pollitt,Craig E Hughes,Chris I Jones
Alice Y Pollitt
Platelets are central mediators of haemostasis, responding rapidly to vascular injury through tightly regulated activation and inhibitory mechanisms. This response is mediated by a range of agonists, membrane receptors, and associated signa...
The Role of H2S in Atherosclerosis and Associated Cardiometabolic Comorbidities [0.03%]
H2S在动脉粥样硬化及其相关心血管代谢合并症中的作用
Odysseia Savvoulidou,Turtushikh Damba,Daniel F J Ketelhuth et al.
Odysseia Savvoulidou et al.
Hydrogen sulfide (H2S) is an important gasotransmitter with multiple roles and is involved in several pathophysiological processes, including atherosclerosis and associated cardiometabolic comorbidities. This chapter examines the molecular ...
Eman Hassan,Will Lester
Eman Hassan
This chapter provides a comprehensive overview of direct oral anticoagulants (DOACs), focusing on their mechanisms of action, clinical utility, and practical considerations in anticoagulation management. DOACs have revolutionised anticoagul...
John Hogwood,Elaine Gray
John Hogwood
This chapter provides an overview of heparin, including discovery, structure, mechanism of action, and principal use for anticoagulation. For over 100 years, heparin has a central role in prophylaxis and treatment of prothrombotic states, b...