Laura Alonso-Herranz,Julián Albarrán-Juárez
Laura Alonso-Herranz
Atherosclerosis, the leading cause of cardiovascular death worldwide, is initiated by endothelial cells (ECs) dysfunction and sustained by maladaptive vascular remodeling. Far from being a uniform barrier, the endothelium is highly heteroge...
Endothelial Dysfunction and Neurovascular Alterations in Autism Spectrum Disorder [0.03%]
自闭症谱系障碍的内皮功能障碍和神经血管改变
Jorge Manzo
Jorge Manzo
The traditional view of autism spectrum disorder (ASD) has largely focused on neuronal mechanisms as the primary drivers of atypical neurodevelopment. However, increasing evidence suggests that vascular and neurovascular processes also cont...
Molecular Mechanisms of Endothelial Shear Stress Mechanotransduction in Health and Disease [0.03%]
健康与疾病状态下的内皮剪切应力力学信号转导的分子机制
Jesus H Beltran-Ornelas,Min Jeong Cho,Gavin Power et al.
Jesus H Beltran-Ornelas et al.
Endothelial cells translate hemodynamic forces into biochemical signals that regulate vascular homeostasis through a process called mechanotransduction. Over the past decades, the study of this physiological process has received significant...
Microvasculature of the Pancreatic Islets of Langerhans in Health and Diabetes [0.03%]
朗格汉斯胰岛的微血管在健康和糖尿病中的情况
D J Hill
D J Hill
Insulin and glucagon secreted by beta- and alpha-cells of the islets of Langerhans, respectively, regulate tissue glucose uptake, metabolism, and glycolysis. Islets represent around 2% of pancreatic mass but receive around 20% of the arteri...
Mechanisms of Actions of Physiological, Pharmacological, and Toxicological Dietary Bioactive Inorganic Boron [0.03%]
生理剂量、药理剂量及有毒剂量的膳食活性无机硼的作用机制研究进展
Forrest H Nielsen
Forrest H Nielsen
Based on a significant amount of evidence from in vitro, animal, and human experiments, the basic aspect of the mechanism of action of nutritional, pharmacological, and toxicologic inorganic boron is the formation of boron esters with biomo...
BNCT Plus Luminescence: New Paradigm for Boron-Containing Drug Design [0.03%]
硼中子捕获治疗联合发光：含硼药物设计的新范式
Xin Liu,Deshuang Tu,Chang-Sheng Lu et al.
Xin Liu et al.
Boron neutron capture therapy (BNCT) is an emerging modality for cancer treatment, where the development of advanced boron-containing drugs is crucial. Recent years have seen the application of boron-containing drugs exhibiting high boron c...
Calcium Fructoborate: Unique Among Other Boron-Carbohydrate Complexes from Nature: Biochemical Roles and Pharmacological Potential [0.03%]
钙果糖硼酸盐：天然其他硼-碳水化合物复合物的独特存在：生化作用和药理潜力
Ion Romulus Scorei,Andrei Biţă,George Dan Mogoşanu et al.
Ion Romulus Scorei et al.
Boron (B) is a trace element with distinctive coordination chemistry that enables the formation of reversible esters with cis-diol-containing ligands, particularly carbohydrates and polyols. Among naturally occurring B-carbohydrate complexe...
Rüya Kuru-Yaşar,Ayşen Yarat
Rüya Kuru-Yaşar
Boron is a naturally occurring trace element that has historically received limited attention in human nutrition and is of increasing biological importance. It is widely found in nature, primarily through food and drinking water, and has at...
Maria Eduarda de Sá Freire Onofre,Renata Trabach Santos,Fernanda Ferreira Cruz et al.
Maria Eduarda de Sá Freire Onofre et al.
Pulmonary hypertension is a progressive and multifactorial disorder associated with a broad spectrum of cardiovascular and respiratory conditions. The updated definition proposed at the World Symposium on Pulmonary Hypertension (mean pulmon...
Biology of the Endothelium [0.03%]
内皮细胞生物学
Jeremy D Pearson
Jeremy D Pearson
Endothelial cell functions are critical for cardiovascular health, and endothelial cell dysfunction underlies the pathology of many cardiovascular diseases. This review summarises the major aspects of endothelial physiology, which together ...