Christina Friedrich
Christina Friedrich
Quantitative systems pharmacology (QSP) is a modeling approach employed in drug research and development that combines mechanistic representations of biological processes with drug pharmacology to deepen biological understanding and predict...
Quantitative Systems Pharmacology Modeling in Immuno-Oncology: Hypothesis Testing, Dose Optimization, and Efficacy Prediction [0.03%]
定量系统药理学在肿瘤免疫治疗中的应用：假设检验、剂量优化及疗效预测模型研究
Hanwen Wang,Theinmozhi Arulraj,Alberto Ippolito et al.
Hanwen Wang et al.
Despite an increasing number of clinical trials, cancer is one of the leading causes of death worldwide in the past decade. Among all complex diseases, clinical trials in oncology have among the lowest success rates, in part due to the high...
Application of Quantitative Systems Pharmacology Approaches to Support Pediatric Labeling in Rare Diseases [0.03%]
定量系统药理学在罕见病儿科适应症中的应用支持定量系统药理学方法在罕见疾病儿科标签支持中的应用
Susana Zaph,Randolph J Leiser,Mengdi Tao et al.
Susana Zaph et al.
Quantitative Systems Pharmacology (QSP) models offer a promising approach to extrapolate drug efficacy across different patient populations, particularly in rare diseases. Unlike conventional empirical models, QSP models can provide a mecha...
The Use of Natural Products for Preventing Cognitive Decline/Providing Neuroprotection [0.03%]
天然产物在防治认知衰退及提供神经保护中的应用
Ozra Tabatabaei-Malazy,Bayan Azizi,Mohammad Abdollahi
Ozra Tabatabaei-Malazy
Neurocognitive disorders are characterized by a decline in various components of cognitive function, resulting in a high rate of morbidity and mortality. Despite multiple efforts, there is still a lack of practical preventive and therapeuti...
Valérie B Schini-Kerth,Ibrahima Diouf,Hira Muzammel et al.
Valérie B Schini-Kerth et al.
Maintaining good vascular health is a major component in healthy ageing as it reduces the risk of cardiovascular diseases. Endothelial dysfunction, in particular, is a key mechanism in the development of major cardiovascular diseases includ...
Thomas Hirse
Thomas Hirse
Public-private partnerships in drug R&D have great potential for driving innovation. They can bridge between excellent fundamental research and development and commercialization of innovative medicines to address unmet needs for the therapy...
Reaching Outer Space and Enabling the mRNA Revolution: A Critical Role of Partnerships for Successful Drug and Vaccine Development [0.03%]
迈向外太空及使mRNA革命成为可能：成功开发药物和疫苗的关键合作伙伴关系作用
Anita Seshire,Yukun Duan,Kahina Lang
Anita Seshire
mRNA and targeted delivery of mRNA carry the promise to enable targeted treatment of undruggable diseases with high unmet medical needs. The transient nature of mRNA opens options for safe influencing of protein biology, immune responses, a...
From Innovator Result-driven to Multi-actor Impact-oriented Public-Private Partnerships: Integrating the Patient Perspective [0.03%]
从以成果为导向的创新者合作到以患者为中心的多主体合作：公共部门和私营部门的合作整合了患者的视角
R L A de Vrueh,J S B de Vlieger,K M Orrling et al.
R L A de Vrueh et al.
Public-Private Partnerships (PPPs) have been crucial in medicine research and development (R&D) for decades. Initially, PPPs involved private and academic innovators working in bilateral collaborations to advance pharmaceutical innovation. ...
Pharmacology of Non-Psychoactive Phytocannabinoids and Their Potential for Treatment of Cardiometabolic Disease [0.03%]
非精神活性植物源性大麻二酚的药理及其潜在的心代谢疾病治疗作用
Cherry L Wainwright,Sarah K Walsh
Cherry L Wainwright
The use of Cannabis sativa by humans dates back to the third millennium BC, and it has been utilized in many forms for multiple purposes, including production of fibre and rope, as food and medicine, and (perhaps most notably) for its psych...
Innovation at the Interface between Academia and Industry: The BioMed X Model [0.03%]
学术界与工业界交叉创新的模式——BioMed X的例子
Flavia-Bianca Cristian,Christian Tidona,Thomas Rückle
Flavia-Bianca Cristian
In the evolving landscape of biomedical research, the convergence of molecular biology and translational medicine has ushered in a new era of pharmaceutical innovation. This paradigm shift, characterized by significant advances in targeted ...