Physiological Functions of the Volume-Regulated Anion Channel VRAC/LRRC8 and the Proton-Activated Chloride Channel ASOR/TMEM206 [0.03%]
容积调节性阴离子通道VRAC/LRRC8和质子激活的氯通道ASOR/TMEM206的生理功能
Yulia Kostritskaia,Malte Klüssendorf,Yingzhou Edward Pan et al.
Yulia Kostritskaia et al.
Volume-regulated anion channels (VRACs) and the acid-sensitive outwardly rectifying anion channel (ASOR) mediate flux of chloride and small organic anions. Although known for a long time, they were only recently identified at the molecular ...
Gender Differences in Cardiovascular Health: Hormonal Effects on Cardiovascular Risk and Management [0.03%]
心血管健康中的性别差异：激素对心血管风险和治疗的影响
Anna Tsirka
Anna Tsirka
Cardiovascular disease is the number one cause of death worldwide both in men and women. Significant differences however exist in the age of onset, type of cardiovascular disease (CVD), and treatment response among the genders. These differ...
Biological and Clinical Implications of Sex-Specific Differences in Alzheimer's Disease [0.03%]
阿尔茨海默病的性别差异及其生物学和临床意义
Jose A Santiago,Judith A Potashkin
Jose A Santiago
Mounting evidence indicates that the female sex is a risk factor for Alzheimer's disease (AD), the most common cause of dementia worldwide. Decades of research suggest that sex-specific differences in genetics, environmental factors, hormon...
Structures of Adrenoceptors [0.03%]
肾上腺受体的结构
Lukas Helfinger,Christopher G Tate
Lukas Helfinger
The first structure of an adrenoceptor (AR), the human β2-adrenoceptor (hβ2AR) was published in 2007 and since then a total of 78 structures (up to June 2022) have been determined by X-ray crystallography and electron cryo-microscopy (cry...
Sonia K Singh,Louise McCullough
Sonia K Singh
There are differences in the prevalence and strength of risk factors in women, along with sex-specific risk factors such as pregnancy. Women have a higher lifetime risk of stroke compared to men, with worse outcomes including higher rates o...
Evangelia Eirini Tsermpini,Alessandro Serretti,Vita Dolžan
Evangelia Eirini Tsermpini
Published Erratum
Handbook of experimental pharmacology. 2023:280:283. DOI:10.1007/164_2023_661 2023
Martin Hennenberg,Martin C Michel
Martin Hennenberg
Adrenoceptors importantly contribute to the physiological regulation of lower urinary tract (LUT) function and have become a target of several clinically successful treatments for major LUT diseases. In the bladder dome, β-adrenoceptor sub...
Hypothalamic-Pituitary-Gonadal Axis Disorders Impacting Fertility in Both Sexes and the Potential of Kisspeptin-Based Therapies to Treat Them [0.03%]
下丘脑-垂体-性腺轴紊乱影响男女生育能力及基于亲吻肽的治疗潜力
Maricedes Acosta-Martínez
Maricedes Acosta-Martínez
Impaired function of the hypothalamic-pituitary-gonadal (HPG) axis can lead to a vast array of reproductive disorders some of which are inherited or acquired, but many are of unknown etiology. Among the clinical consequences of HPG impairme...
Ebru Arioglu-Inan,Gizem Kayki-Mutlu
Ebru Arioglu-Inan
Sexual dimorphism has been demonstrated to have an effect on various physiological functions. In this regard, researchers have investigated its impact on glucose homeostasis in both preclinical and clinical studies. Sex differences mainly a...
Juliane Sachau,Ralf Baron
Juliane Sachau
Neuropathic pain is a common chronic pain condition that is caused by a lesion or disease of the somatosensory nervous system. The multitude of sensory negative and positive sensations and associated comorbidities have a major impact on qua...