Ulrike Alexiev,Eckart Rühl
Ulrike Alexiev
In this chapter, the visualization of nanocarriers and drugs in cells and tissue is reviewed. This topic is tightly connected to modern drug delivery, which relies on nanoscopic drug formulation approaches and the ability to probe nanoparti...
Pharmacology of Compounds Targeting Cation-Chloride Cotransporter Physiology [0.03%]
针对阳离子-氯化物共转运蛋白生理的化合物的药理学研究进展
Eric Delpire,Andrew S Terker,Kenneth B Gagnon
Eric Delpire
Transporters of the solute carrier family 12 (SLC12) carry inorganic cations such as Na+ and/or K+ alongside Cl across the plasma membrane of cells. These tightly coupled, electroneutral, transporters are expressed in almost all tissues/org...
Lin Cai,Ruxiang Wang,Donghui Zhang
Lin Cai
The rhythmically beating heart is the foundation of life-sustaining blood flow. There are four chambers and many different types of cell in the heart, but the twisted myofibrillar structures formed by cardiomyocytes are particularly importa...
Ilaria Campesi,Margherita Ruoppolo,Flavia Franconi et al.
Ilaria Campesi et al.
Sexual dimorphism creates different biological and cellular activities and selective regulation mechanisms in males and females, thus generating differential responses in health and disease. In this scenario, the sex itself is a source of p...
Blood-Brain Barrier (BBB)-Crossing Strategies for Improved Treatment of CNS Disorders [0.03%]
改善中枢神经系统疾病治疗的血脑屏障(BBB)穿越策略
Wandong Zhang
Wandong Zhang
Blood-brain barrier (BBB) is a special biological property of the brain neurovascular unit (including brain microvessels and capillaries), which facilitates the transport of nutrients into the central nervous system (CNS) and exchanges meta...
Kevin L Zacharoff
Kevin L Zacharoff
Pain is a highly personal experience. Pain is often considered to be a purely neurologic phenomenon, but in actuality, it is a combination of both sensory and emotional experiences. This has sometimes been translated clinically toward a mor...
S Clare Stanford,David J Heal
S Clare Stanford
Research into the involvement of adrenoceptor subtypes in the cause(s) of psychiatric disorders is particularly challenging. This is partly because of difficulties in developing animal models that recapitulate the human condition but also b...
Adrenal Anion Channels: New Roles in Zona Glomerulosa Physiology and in the Pathophysiology of Primary Aldosteronism [0.03%]
肾上腺阴离子通道在球旁细胞生理学及原发性醛固酮增多症发病机制中的新角色
Gabriel Stölting,Ute I Scholl
Gabriel Stölting
The mineralocorticoid aldosterone is produced in the zona glomerulosa of the adrenal cortex. Its synthesis is regulated by the serum concentrations of the peptide hormone angiotensin II and potassium. The primary role of aldosterone is to c...
Locus Coeruleus and Noradrenergic Pharmacology in Neurodegenerative Disease [0.03%]
蓝斑和去甲肾上腺素药理学在神经退行性疾病中的作用
Rachel A Matt,Renee S Martin,Andrew K Evans et al.
Rachel A Matt et al.
Adrenoceptors (ARs) throughout the brain are stimulated by noradrenaline originating mostly from neurons of the locus coeruleus, a brainstem nucleus that is ostensibly the earliest to show detectable pathology in neurodegenerative diseases ...
Wei Zhu,Xiaoyan Zhang,Shen Wu et al.
Wei Zhu et al.
The trabecular meshwork (TM) of the eye serves as an essential tissue in controlling aqueous humor (AH) outflow and intraocular pressure (IOP) homeostasis. However, dysfunctional TM cells and/or decreased TM cellularity is become a critical...