Applications of Induced Pluripotent Stem Cell-Derived Glia in Brain Disease Research and Treatment [0.03%]
诱导多能干细胞来源的胶质细胞在脑疾病研究和治疗中的应用
Zhiqi Yang,Mingyue Gong,Chuanyan Yang et al.
Zhiqi Yang et al.
Glia are integral components of neural networks and are crucial in both physiological functions and pathological processes of the brain. Many brain diseases involve glial abnormalities, including inflammatory changes, mitochondrial damage, ...
Nour Allahham,Ines Colic,Melissa L D Rayner et al.
Nour Allahham et al.
In addition to proteins, discussed in the Chapter "Advances in Vaccine Adjuvants: Nanomaterials and Small Molecules", there are a wide range of alternatives to small molecule active ingredients. Cells, extracellular vesicles, and nucleic ac...
Jillian G Baker,Dominick E Shaw
Jillian G Baker
Asthma has been recognised as a respiratory disorder for millennia and the focus of targeted drug development for the last 120 years. Asthma is one of the most common chronic non-communicable diseases worldwide. Chronic obstructive pulmonar...
Liên S Reichel,Anja Traeger
Liên S Reichel
Considering nucleic acids as the language of life and the genome as the instruction manual of cells, their targeted modulation promises great opportunities in treating and healing diseases. In addition to viral gene transfer, the overwhelmi...
Ilva D Rupenthal,Priyanka Agarwal
Ilva D Rupenthal
The eye has several dynamic and static barriers in place to limit the entry of foreign substances including therapeutics. As such, efficient drug delivery, especially to posterior segment tissues, has been challenging. This chapter describe...
Human Retinal Organoids in Therapeutic Discovery: A Review of Applications [0.03%]
人视网膜类器官在治疗发现中的应用：综述
Lin Cheng,Markus H Kuehn
Lin Cheng
Human embryonic stem cells (hESCs)- and induced pluripotent stem cells (hiPSCs)-derived retinal organoids (ROs) are three-dimensional laminar structures that recapitulate the developmental trajectory of the human retina. The ROs provide a f...
Eva Becher,Sabine Oertelt-Prigione
Eva Becher
Sex and gender play a pivotal role in health and disease. Differences can be identified in symptoms, biomarkers, lifetime experiences of diseases, incidence, prevalence, therapeutic options, health-related behavior, and resiliency. However,...
Therapeutics for Substance-Using Women: The Need to Elucidate Sex-Specific Targets for Better-Tailored Treatments [0.03%]
阐释性别特异性靶点以更好地针对女性成瘾者制定治疗措施的必要性
Helen C Fox,Verica Milivojevic,Rajita Sinha
Helen C Fox
In the last decade, alcohol consumption in the US has risen by 84% in women compared with 35% in men. Furthermore, research has shown that sex- and gender-related differences may disadvantage women in terms of developing a range of psycholo...
Nanomedicine - Immune System Interactions: Limitations and Opportunities for the Treatment of Cancer [0.03%]
纳米医学与免疫系统相互作用：癌症治疗的局限性与机遇
Sara Elsafy,Josbert Metselaar,Twan Lammers
Sara Elsafy
Nanoparticles interact with immune cells in many different ways. These interactions are crucially important for determining nanoparticles' ability to be used for cancer therapy. Traditionally, strategies such as PEGylation have been employe...
Andrea Ahles,Stefan Engelhardt
Andrea Ahles
Adrenoceptors are class A G-protein-coupled receptors grouped into three families (α1-, α2-, and β-adrenoceptors), each one including three members. All nine corresponding adrenoceptor genes display genetic variation in their coding and ...