Yixuan Pan,Bing Li
Yixuan Pan
Transcription is organized through a continuum of protein-protein interactions spanning from highly specific, stoichiometric assemblies to dynamic, multivalent contacts. In this review, we summarize structural, biochemical, and functional e...
A categorization of spatial transcriptomics methods for cell-cell communication analysis [0.03%]
空间转录组学方法分析细胞间通讯的分类
Zlatka Fischer,Katharina Imkeller,Marcel H Schulz et al.
Zlatka Fischer et al.
Cell-cell communication (CCC) is involved in regulating cellular behavior in tissues. Spatial transcriptomics adds local context to gene expression, enabling more biologically grounded CCC inference than single-cell RNA-seq alone. Rapid met...
Solveig Løkhammer,Charlotte A M Cecil,Astanand Jugessur et al.
Solveig Løkhammer et al.
In multicellular organisms, epigenetic inheritance is a process by which traits induced by life experiences or environmental factors in a parent are passed to offspring without involving changes in the DNA sequence, but rather in the epigen...
Ying Zhang,Chen-Long Wang,Lifang Wu et al.
Ying Zhang et al.
Allele-specific expression (ASE) serves as a unique readout for understanding how genetic and epigenetic variations fine-tune gene regulation in diploid organisms. While allelic transcriptional control mediated by cis-elements and epigeneti...
Kaylah B Samuelson,Stacey L Hanlon
Kaylah B Samuelson
In addition to the essential set of chromosomes, individuals can carry supernumerary chromosomes that are not required for normal growth, development, or reproduction. Collectively, these extra chromosomes are called B chromosomes, and mode...
James M Sikela
James M Sikela
Neoteny-a developmental slowdown that results in the retention of juvenile traits into adulthood-has long been viewed as central to human brain expansion. Olduvai domains are proposed here to function as a dosage-dependent metabolic 'brake'...
Hidenori Tani
Hidenori Tani
Steady-state RNA sequencing measures abundance-synthesis over decay-not activity, so abundance is an imperfect proxy for long noncoding RNA (lncRNA) function. A small, fast-decaying subpopulation can be filtered out. Reading turnover alongs...
Spliced [0.03%]
拆合ゲルmtimeclearfix
Maria A Smit
Maria A Smit
Lea Pradel,Aline Marnef,Gaelle Legube
Lea Pradel
When DNA double-strand breaks (DSBs) arise within actively transcribed loci, cells must tightly coordinate transcription with DNA repair to avoid detrimental interference between these processes. This coordination is initiated by signaling ...
Beyond gene expression: Single-cell transcriptomics at isoform resolution [0.03%]
单细胞转录组测序的同种异型分辨率超越基因表达水平
Feng Wang,Yi Xing,Lan Lin
Feng Wang
Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular heterogeneity, yet traditional scRNA-seq methods primarily capture transcript ends, limiting analyses to total gene expression. Advances in isoform-reso...