Overconsumption and obesity: peptides and susceptibility to weight gain [0.03%]
过度消费与肥胖：肽类和易于体重增加的倾向
J E Blundell,F Levin,N A King et al.
J E Blundell et al.
Physiological control of feeding is mediated by tonic and episodic signalling systems. These are sometimes thought of as long-term and short-term control. Tonic signals arise from tissue stores whereas episodic signals oscillate periodicall...
Alfonso Abizaid,Tamas L Horvath
Alfonso Abizaid
Recent years have seen an impetus in the study for central mechanisms regulating energy balance, and caloric intake possibly as a response to the obesity pandemic. This renewed interest as well as drastic improvements in the tools that are ...
A potent, non-toxic insulin-releasing peptide isolated from an extract of the skin of the Asian frog, Hylarana guntheri (Anura:Ranidae) [0.03%]
一种从亚洲蛙Hylarana guntheri皮肤中提取的胰岛素促泌多肽
J Michael Conlon,Gavin J Power,Yasser H A Abdel-Wahab et al.
J Michael Conlon et al.
Peptides in extract of the skin of the Asian frog Hylarana guntheri Boulenger,1882 were purified by reversed-phase HPLC and individual components analysed for their ability to release insulin from the rat BRIN-BD11 clonal beta cell line. Th...
The transcriptional co-activator PGC-1alpha up regulates apelin in human and mouse adipocytes [0.03%]
转录共激活因子PGC-1α可上调人类和小鼠脂肪细胞中的附似素基因的表达
Anne Mazzucotelli,Carole Ribet,Isabelle Castan-Laurell et al.
Anne Mazzucotelli et al.
By using pangenomic microarray, we identified apelin as a unique adipokine up regulated by the transcriptional co-activator peroxisome proliferator-activated receptor gamma (PPARgamma) co-activator 1alpha (PGC-1alpha) in human white adipocy...
A new endogenous form of PYY isolated from canine ileum: Gly-extended PYY(1-36) [0.03%]
从犬回肠中分离出的一种新的内源性PYY形式：Gly-延伸的PYY(1-36)
David A Keire,Julian P Whitelegge,Sara Bassilian et al.
David A Keire et al.
We purified and identified the peptide YY (PYY) forms present and determined their levels from a portion of the canine ileum directly adjacent to the cecum by a new extraction method designed to prevent and evaluate degradation of endogenou...
Ullamari Pesonen
Ullamari Pesonen
Neuropeptide Y (NPY) is an abundant and widespread peptide in mammalian nervous system, both in the central and peripheral nervous systems. NPY is a multifunctional neurotransmitter with multiple modulator effects in the regulation of physi...
Vagotomy enhances experimental metastases of 4THMpc breast cancer cells and alters substance P level [0.03%]
切断迷走神经促进4THMpc乳腺癌细胞实验性转移并改变缓激肽的水平
Nuray Erin,Güliz Akdas Barkan,John F Harms et al.
Nuray Erin et al.
We have previously demonstrated that inactivation of capsaicin-sensitive sensory neurons enhances lung and heart metastases of breast carcinoma. Because a significant part of sensory innervation of lung tissue is supplied by the vagus nerve...
Leila Karhunen,Karl-Heinz Herzig
Leila Karhunen
William A Banks
William A Banks
The BBB prevents the unrestricted exchange of substances between the central nervous system (CNS) and the blood. The blood-brain barrier (BBB) also conveys information between the CNS and the gastrointestinal (GI) tract through several mech...
Hans-Rudolf Berthoud
Hans-Rudolf Berthoud
Food interacts with sensors all along the alimentary canal to provide the brain with information regarding its composition, energy content, and beneficial effect. Vagal afferents innervating the gastrointestinal tract, pancreas, and liver p...