Intranasal administration of mouse [D-Leu-4]OB3, a synthetic peptide amide with leptin-like activity, enhances total uptake and bioavailability in Swiss Webster mice when compared to intraperitoneal, subcutaneous, and intramuscular delivery systems [0.03%]
与腹腔、皮下和肌肉给药系统相比，鼻内施用具有类似瘦素活性的合成肽[D-Leu-4]OB3可提高瑞士 Webster 小鼠的总吸收率和生物利用度
Zachary M Novakovic,Matthew C Leinung,Daniel W Lee et al.
Zachary M Novakovic et al.
Using a synthetic peptide strategy, we localized an active domain in mouse leptin to a sequence between amino acids 106 and 140. Intraperitoneal (ip) administration of a number of synthetic peptide amides encompassed by this domain reduced ...
Comparative Study
Regulatory peptides. 2009 Apr 10;154(1-3):107-11. DOI:10.1016/j.regpep.2009.01.002 2009
Expression of the serotonin transporter SERT in the genital tract of cattle [0.03%]
牛生殖道中的血清素转运体SERT的表达
Luigi M Pavone,Simona Tafuri,Roberta Lo Muto et al.
Luigi M Pavone et al.
Both prostate and vestibular glands of mammals contain neuroendocrine cells which synthesize, store and release growth factors including neuropeptides and biogenic amines such as serotonin. An increase of the secretory products by these cel...
Significance of salivary adrenomedullin in the maintenance of oral health: stimulation of oral cell proliferation and antibacterial properties [0.03%]
saliva中肾上腺素介素在维持口腔健康方面的意义：刺激口腔细胞增殖和抗菌性能
Michael Gröschl,Olaf Wendler,Hans-Georg Topf et al.
Michael Gröschl et al.
Adrenomedullin (ADM) promotes epithelial cell proliferation and antimicrobial activity in the gastrointestinal tract. Since ADM is also present in saliva, it was the objective of our study to investigate the role of salivary ADM in the main...
Elevated expression of urotensin II and its receptor in skeletal muscle of diabetic mouse [0.03%]
糖尿病小鼠骨骼肌中尿调素II及其受体表达上调
Hong Xia Wang,Xiang Jun Zeng,Yue Liu et al.
Hong Xia Wang et al.
Urotensin II (UII) is a somatostatin-like peptide recently identified to be involved in metabolic regulation and to play a significant role in diabetes and its complications. In the present study, we investigated the expression of UII and i...
Short-term physiological hyperleptinemia decreases arterial blood pressure [0.03%]
短期生理性高胰岛素血症降低动脉血压
W David Knight,R Seth,J Boron et al.
W David Knight et al.
We examined the possibility that chronic, low-dose peripheral leptin infusion would inhibit food intake but not increase blood pressure. Male Fisher Brown Norway (FBNF1) and Sprague-Dawley (SD) rats were instrumented for cardiovascular tele...
Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia [0.03%]
大鼠和人类三叉神经节神经元中的内源性血管紧张素系统
Hans Imboden,Jaspal Patil,Juerg Nussberger et al.
Hans Imboden et al.
To clarify the role of Angiotensin II (Ang II) in the sensory system and especially in the trigeminal ganglia, we studied the expression of angiotensinogen (Ang-N)-, renin-, angiotensin converting enzyme (ACE)- and cathepsin D-mRNA, and the...
Modification of atrial natriuretic peptide system in cold-induced hypertensive rats [0.03%]
冷诱导高血压大鼠心房利钠肽系统的变化研究
Kuichang Yuan,Xuanshun Jin,Woo Hyun Park et al.
Kuichang Yuan et al.
Cold exposure induces hypertension and cardiac hypertrophy via sympathetic activation. The sympathetic nervous system is fundamentally important for the regulation of cardiac atrial natriuretic peptide (ANP) secretion. The present study aim...
Natriuretic peptides as regulatory mediators of secretory activity in the digestive system [0.03%]
纳尿肽作为消化系统分泌活动的调节介质
Maria Eugenia Sabbatini
Maria Eugenia Sabbatini
Atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) are members of the natriuretic peptide family best known for their role in blood pressure regulation. However, in recent years all the natriuretic peptides and their rece...
Interleukin-1beta induces the novel adipokine chemerin in adipocytes in vitro [0.03%]
白细胞介素-1β在体外实验中诱导脂肪细胞产生新型脂肪细胞因子chemerin
Susan Kralisch,Sebastian Weise,Grit Sommer et al.
Susan Kralisch et al.
Chemerin has recently been characterized as a novel adipokine playing a crucial role in adipocyte differentiation and insulin signalling. In the current study, the impact of insulin resistance-inducing and proinflammatory interleukin (IL)-1...
Distribution and developmental changes in ghrelin-immunopositive cells in the gastrointestinal tract of African ostrich chicks [0.03%]
非洲鸵鸟雏鸡胃肠中ghrelin免疫反应阳性细胞的分布与发育变化
J X Wang,K M Peng,H Zh Liu et al.
J X Wang et al.
Ghrelin, the endogenous ligand for the growth hormone secretagogue receptor (GHS-R), has been found in the gastrointestinal tract of many vertebrates, but little is known about its distribution in the gastrointestinal tract of African ostri...