Alexander Dubeykovskiy,Thomas Nguyen,Zinaida Dubeykovskaya et al.
Alexander Dubeykovskiy et al.
The unprocessed gastrin precursor, progastrin (PG), is often overexpressed in colon cancer and other malignancies where it appears to stimulate colonic growth. Overexpression of progastrin also stimulates proliferation of normal colonic muc...
Impaired glucose-stimulated insulin secretion in the GK rat is associated with abnormalities in islet nitric oxide production [0.03%]
Henrik Mosén,Claes-Göran Ostenson,Ingmar Lundquist et al.
Henrik Mosén et al.
We investigated implications of nitric oxide (NO) derived from islet neuronal constitutive NO synthase (ncNOS) and inducible NOS (iNOS) on insulin secretory mechanisms in the mildly diabetic GK rat. Islets from GK rats and Wistar controls w...
Effects of cold exposure, exogenous melatonin and short-day treatment on the weight-regulation and body temperature of the Siberian hamster (Phodopus sungorus) [0.03%]
Tuula Korhonen,Anne-Mari Mustonen,Petteri Nieminen et al.
Tuula Korhonen et al.
Objective: To investigate how winter acclimatization (WA), exogenous melatonin (MEL) or endogenous melatonin (SD) affect plasma leptin and ghrelin concentrations and how leptin and ghrelin contribute to the regulation of ...
Andreas Lindqvist,Annemie Baelemans,Charlotte Erlanson-Albertsson
Andreas Lindqvist
In the Western world, consumption of soft drinks has increased the last three decades and is partly responsible for the epidemic-like increase in obesity. Soft drinks, originally sweetened by sucrose, are now sweetened by other caloric swee...
Activation of submucosal but not myenteric plexus of the gastrointestinal tract accompanies reduction of food intake by camostat [0.03%]
Shannon J Raboin,Joseph R Reeve Jr,Marvis S Cooper et al.
Shannon J Raboin et al.
It has been shown in the rat that endogenous cholecystokinin (CCK), released in response to the non-nutrient trypsin inhibitor camostat, reduces food intake at meals and increases Fos-like immunoreactivity (Fos-LI; a marker for neuronal act...
Inhibitory effect of somatostatin on prostaglandin E2 synthesis by primary neonatal rat glial cells [0.03%]
Naama Dror,Liat Tveria,Inbal Meniv et al.
Naama Dror et al.
Glial inflammation plays an integral role in the development of neurodegenerative disease. Although somatostatin is known to be a local anti-inflammatory factor in the periphery, evidence of a similar function in the brain is scarce. The ai...
B-type natriuretic peptide (BNP) attenuates the L-type calcium current and regulates ventricular myocyte function [0.03%]
R Sodi,E Dubuis,A Shenkin et al.
R Sodi et al.
A fundamental question in physiology is how hormones regulate the functioning of a cell or organ. It was therefore the aim of this study to investigate the effect(s) of BNP-32 on calcium handling by ventricular myocytes obtained from the ra...
Disulfide-containing peptides from the glandular skin secretions of froglets of the genus Crinia: structure, activity and evolutionary trends [0.03%]
齿突蛙属幼体皮肤腺分泌中的含二硫键多肽：结构、活性及进化趋势
Rebecca J Jackway,Tara L Pukala,Vita M Maselli et al.
Rebecca J Jackway et al.
The skin secretions of Crinia signifera, C. riparia and C. deserticola contain bioactive disulfide-containing peptides. Signiferin 1 (RLCIPYIIPC-OH) from C. signifera and C. deserticola) contracts smooth muscle at a concentration of 10(-9) ...
Vera Todorović,Predrag Pesko,Marjan Micev et al.
Vera Todorović et al.
Growth factors play an important role in orchestrating and enabling the cellular responses required for successful wound healing. In the present study, rat surgical incision was used to investigate insulin-like growth factor-I (IGF-I) expre...
Involvement of ORL1 receptor and ERK kinase in the orphanin FQ-induced nociception in the nucleus accumbens of rats [0.03%]
大鼠伏隔核中孤儿素FQ诱导的疼痛行为与ORL1受体和ERK激酶的关系研究
Li-Ying Chen,Jia-Xin Huang,Long-Chuan Yu
Li-Ying Chen
Nociceptin/orphanin FQ (N/OFQ) is a heptadecapeptide, which has been identified as an endogenous ligand of the opioid receptor-like (ORL1) receptor. The present study investigated the nociceptive effect of intra-nucleus accumbens (intra-NAc...