Regulation and role of p21-activated kinase 3 by corticotropin-releasing factor in mouse pituitary [0.03%]
糖皮质激素释放激素对小鼠垂体中p21活化激酶3的调节作用及意义
Kazunori Kageyama,Satoru Sakihara,Toshihiro Suda
Kazunori Kageyama
Corticotropin-releasing factor (CRF) is a major regulatory peptide in the hypothalamic-pituitary-adrenal (HPA) axis under stress conditions. In response to stress, CRF, produced in the hypothalamic paraventricular nucleus, releases adrenoco...
Peripheral GLP-1 gastroprotection against ethanol: the role of exendin, NO, CGRP, prostaglandins and blood flow [0.03%]
外周GLP-1对酒精的胃保护作用：内源性和外源性GLP-1的作用及NO、CGRP、前列腺素和血流的参与
Naciye Isbil-Buyukcoskun,Guldal Gulec,Betul Cam-Etoz et al.
Naciye Isbil-Buyukcoskun et al.
The aim of this study was to investigate the effects of peripherally injected glucagon like peptide-1 (GLP-1) on ethanol-induced gastric mucosal damage and the mechanisms included in the effect. Absolute ethanol was administered through an ...
Autoinhibition of endothelial nitric oxide synthase (eNOS) in gut smooth muscle by nitric oxide [0.03%]
一氧化氮通过内皮型一氧化氮合酶的自身抑制作用调节肠平滑肌功能
John R Grider,Karnam S Murthy
John R Grider
Nitric oxide in the gut is produced by nNOS in enteric neurons and by eNOS in smooth muscle cells. The eNOS in smooth muscle is activated by vasoactive intestinal peptide (VIP) released from enteric neurons. In the present study, we examine...
Short-term oral oleoyl-estrone decreases the expression of ghrelin in the rat stomach [0.03%]
口服油酰雌烯醇减少大鼠胃中生长抑素的表达
Raquel Ferrer-Lorente,José-Antonio Fernández-López,Marià Alemany et al.
Raquel Ferrer-Lorente et al.
Oleoyl-estrone (OE) mobilizes body fat and decreases food intake. The precise mechanism of its modulation of appetite is unknown. Since the effects of OE on food intake appear early, here we studied the effect of OE on the expression of gut...
Angiotensin processing is partially carried out by carboxypeptidases in the rat mesenteric arterial bed perfusate [0.03%]
大鼠肠系膜动脉床灌流液中的激肽类处理部分由羧基肽酶完成
Hugo J V Pereira,Laura L Souza,Maria Cristina O Salgado et al.
Hugo J V Pereira et al.
Here we investigated the possible association between the carboxypeptidase A (CPA)-like activity of the rat mesenteric arterial bed (MAB) perfusate and the ability of this fluid of forming angiotensin (Ang) 1-9 and Ang 1-7 upon incubation w...
The role of ether-a-go-go-related gene K(+) channels in glucocorticoid inhibition of adrenocorticotropin release by rat pituitary cells [0.03%]
ERG钾通道在糖皮质激素抑制促肾上腺皮质素释放中的作用研究
Miho Yamashita,Yutaka Oki,Kazumi Iino et al.
Miho Yamashita et al.
The present study investigated the role of K(+) channels in the inhibitory effect of glucocorticoid on adrenocorticotropin (ACTH) release induced by corticotropin-releasing hormone (CRH) using cultured rat anterior pituitary cells. Apamin a...
Effect of exendin-4 treatment upon glucose uptake parameters in rat liver and muscle, in normal and type 2 diabetic state [0.03%]
Exendin-4治疗对正常及2型糖尿病状态大鼠肝、肌糖转运参数的影响
Luis Arnés,Paola Moreno,Bernardo Nuche-Berenguer et al.
Luis Arnés et al.
Exendin-4, like GLP-1, is insulinotropic, antidiabetic and glucoregulatory among other properties, which are thought to be exerted through the pancreatic GLP-1 receptor; exendin-4 is also an agonist of the GLP-1 stimulatory action upon live...
Vagotomy and accompanying pyloroplasty down-regulates ghrelin mRNA but does not affect ghrelin secretion [0.03%]
迷走神经切断伴幽门成形术下调胃泌素mRNA但并不影响胃泌素的释放
Charlotte Erlanson-Albertsson,Andreas Lindqvist
Charlotte Erlanson-Albertsson
In this study, we have examined how the lack of vagus activity affects the long-term secretion of total and active ghrelin. We subjected mice to sham-operation, pyloroplasty or vagotomy and pyloroplasty. The study lasted for 2 weeks, during...
Role of the rat gastrointestinal mucosa in catabolism of endothelin peptides [0.03%]
大鼠胃肠粘膜在内皮素肽类分解代谢中的作用
Roman M Janas,Jadwiga Janas,Krzysztof Warnawin et al.
Roman M Janas et al.
Endothelin-1 is involved in physiology and pathophysiology of the alimentary tract. The peptide modulates blood flow in the gastrointestinal microvasculature and regulates contractility of smooth muscles and, when present in excess, may be ...
Venous endotelin-1 (ET-1) and brain natriuretic peptide (BNP) plasma levels during 6-month bosentan treatment for pulmonary arterial hypertension [0.03%]
治疗肺动脉高压6个月期间静脉内内皮素-1和脑利钠肽血浆水平的变化
Carmine Dario Vizza,Claudio Letizia,Luigi Petramala et al.
Carmine Dario Vizza et al.
Objective: Bosentan, an endothelin (ET) ETA-ETB receptors antagonist, is an effective therapy for idiopathic pulmonary arterial hypertension (PAH) and for PAH related to connective tissue disease (CTD). The aim of this st...