Marisa R Citarella,Marcelo R Choi,Mariela M Gironacci et al.
Marisa R Citarella et al.
Since renal natriuretic peptide urodilatin (URO) exerts similar natriuretic and diuretic actions to those of atrial natriuretic factor (ANF), we hypothesized that URO regulates renal dopamine (DA) availability, contributing to Na(+), K(+)-A...
Evaluation of new leptin fragments on food intake and body weight of normal rats [0.03%]
新型脂蛋白片段对正常大鼠摄食和体重的影响评价研究
M N C Martins,M M Telles,J C S Zemdegs et al.
M N C Martins et al.
Leptin, a protein hormone originating from adipose tissue, circulates in the plasma and affects the energy balance by interacting with the hypothalamus. Leptin plays an important role in the regulation of a variety of physiological function...
Altered leptin secretion in hyperinsulinemic mice under hypoxic conditions [0.03%]
低氧条件下高胰岛素小鼠的瘦素分泌异常
Iris Ostreicher,Udo Meissner,Christian Plank et al.
Iris Ostreicher et al.
Objective: Hypoxia and insulin are known key players in the activation leptin transcription and translation in vivo and in vitro. These insulin- and hypoxia-dependent effects are leptin transcription are mediated via inde...
Angiotensin II induces superoxide generation via NAD(P)H oxidase activation in isolated rat pancreatic islets [0.03%]
血管紧张素II通过激活NAD(P)H氧化酶诱导分离的胰岛中超氧化物生成
A E Hirata,D Morgan,H R Oliveira-Emilio et al.
A E Hirata et al.
Angiotensin II (Ang II) controls blood pressure, electrolyte balance, cell growth and vascular remodeling. Ang II activates NAD(P)H oxidase in several tissues with important function in the control of insulin secretion. Considering the conc...
Antidiabetic effects of sub-chronic activation of the GIP receptor alone and in combination with background exendin-4 therapy in high fat fed mice [0.03%]
高脂喂养小鼠中葡萄糖依赖性促胰岛素多肽受体的抗糖尿病效应及其与基础艾塞那肽治疗联合应用的效果：亚慢性激活作用
Nigel Irwin,Kerry Hunter,Norma Frizzell et al.
Nigel Irwin et al.
GLP-1 and GIP are the two key incretin hormones that regulate post-prandial glucose homeostasis. Furthermore, potent enzyme-resistant GIP and GLP-1 receptor agonists such as N-AcGIP and exendin-4 have now been developed. In the present stud...
Polypeptide from Chlamys farreri modulates UVB-induced activation of NF-kappaB signaling pathway and protection HaCaT cells from apoptosis [0.03%]
刺参多肽通过调节UVB诱导的NF-κB信号通路保护HaCaT细胞免受凋亡损伤
Xiaojin Liu,Zhengyang Zhang,Ping Li et al.
Xiaojin Liu et al.
Polypeptide from Chlamys farreri (PCF) possesses strong antioxidant and photochemo-preventive properties. Our previous study has preliminarily demonstrated that PCF could reduce the intracellular reactive oxygen species (ROS) production and...
The hypothalamus-pituitary-adrenal axis does not influence the protective effects of nociceptin/orphanin FQ on the rat gastric mucosa [0.03%]
脑-肠轴不参与伤害性肽/孤儿素FQ对大鼠胃粘膜的保护作用
Daniela Grandi,Elvira Solenghi,Remo Guerrini et al.
Daniela Grandi et al.
The participation of hypothalamus-pituitary-adrenal axis in the gastroprotective effects of nociceptin/orphanin FQ (N/OFQ) has been investigated. Gastric mucosal lesions were induced by intragastric administration of 50% ethanol, 1 ml/rat. ...
Inhibition of compensatory renal growth by the N-terminus of a sheep-derived peptide [0.03%]
sheep衍生肽N端抑制肾脏代偿性增生作用
J L Haylor,E Parker,G P Risbridger et al.
J L Haylor et al.
The N-terminal sequence of a novel sheep-derived peptide with growth inhibitory activity has been obtained. The N-terminal fragment was chemically synthesised and designated EPL001. The kidney was chosen as the first mammalian system in whi...
Tripeptides from dietary proteins inhibit TNFalpha-induced monocyte adhesion to human aortic endothelial cells [0.03%]
dietarily释放的三肽抑制TNFα诱导的单核细胞黏附到人主动脉内皮细胞中
Robert Ringseis,Vera Götze,Klaus Eder
Robert Ringseis
Dietary proteins have been shown to reduce atherosclerosis development. Although the components of proteins responsible for this effect are largely unknown, it has been suggested that specific bioactive peptides are involved. In order to el...
Stimulatory and Inhibitory regulation of lipolysis by the NPR-A/cGMP/PKG and NPR-C/G(i) pathways in rat cultured adipocytes [0.03%]
NPRA/cGMP/PKG和NPRC/Gi途径对大鼠培养脂肪细胞脂解的刺激与抑制调节作用
Toshio Nishikimi,Chikako Iemura-Inaba,Kazumi Akimoto et al.
Toshio Nishikimi et al.
Objective: Recent studies have suggested the abundant expression of natriuretic peptide receptor in adipose tissue. This study was designed to investigate the levels of natriuretic receptor-A (NPR-A) and NPR-C gene expres...