Natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system has inhibitory effects in renal fibrosis in mice [0.03%]
钠尿肽/钠尿肽受体A系统对小鼠肾纤维化具有抑制作用
Toshio Nishikimi,Chikako Inaba-Iemura,Kimihiko Ishimura et al.
Toshio Nishikimi et al.
Object: This study was designed to examine whether natriuretic peptide/natriuretic peptide receptor-A (NPR-A) system attenuates renal fibrosis in a unilateral ureteral obstruction (UUO) model and also examined the mechani...
Selective effect of INGAP-PP upon mouse embryonic stem cell differentiation toward islet cells [0.03%]
INGAP多肽选择性诱导小鼠胚胎干细胞向胰岛细胞分化的作用
Flavio Francini,Héctor Del Zotto,María L Massa et al.
Flavio Francini et al.
We evaluated the effect of islet neogenesis-associated protein pentadecapeptide (INGAP-PP) upon islet beta- and non-beta cell differentiation from mouse embryonic stem (mES) cells. ES-D3 cell lines were cultured following Lumelsky's protoco...
Carnosine inhibits high glucose-induced mesangial cell proliferation through mediating cell cycle progression [0.03%]
卡尼丁通过调控细胞周期抑制高糖诱导的系膜细胞增殖作用
Huijie Jia,Xiaodan Qi,Shaohong Fang et al.
Huijie Jia et al.
Increased mesangial cell proliferation is one of the major pathologic features in the early stage of diabetic nephropathy (DN). Carnosine is an endogenously synthesized dipeptide that has been reported as a protective factor in diabetic nep...
Evidence for a modulatory role of orexin A on the nitrergic neurotransmission in the mouse gastric fundus [0.03%]
orexin A调节小鼠胃底硝基神经传递的证据
Maria Caterina Baccari,Daniele Bani,Franco Calamai
Maria Caterina Baccari
The presence of orexins and their receptors in the gastrointestinal tract supports a local action of these peptides. Aim of the present study was to investigate the effects of orexin A (OXA) on the relaxant responses of the mouse gastric fu...
Role of CREB in vasoactive intestinal peptide-mediated wound healing in human bronchial epithelial cells [0.03%]
CREB在血管活性肠肽介导的人支气管上皮细胞伤口修复中的作用
Cha-Xiang Guan,Yan-Ru Cui,Guo-Ying Sun et al.
Cha-Xiang Guan et al.
Vasoactive intestinal peptide (VIP) is one of the most important sensory neuropeptides in respiratory system. We previously reported that VIP enhances wound healing and proliferation of human bronchial epithelial cells (HBECs), and these ef...
Helio Miranda Costa-Junior,Mariana J Suetsugu,José Eduardo Krieger et al.
Helio Miranda Costa-Junior et al.
Protein kinases are key drug targets for several diseases. However, despite large efforts, the development of drugs that are specific for these kinases has been a great challenge. The discovery that protein-protein interactions can be media...
Fetuin-A and arterial stiffness in patients with normal kidney function [0.03%]
正常肾功能患者载脂蛋白A与动脉僵硬度的关系
Marcel Roos,Tom Richart,Tatiana Kouznetsova et al.
Marcel Roos et al.
Aim: To evaluate the association between fetuin-A level (AHSG), its encoding gene (Thr256Ser) and arterial function in subjects with normal kidney function. ...
RXFP1-inactive relaxin activates human glucocorticoid receptor: further investigations into the relaxin-GR pathway [0.03%]
无活性的 Relaxin 通过激活糖皮质激素受体信号通路影响人类生殖和肿瘤进展：深入研究 RELAXIN-GLUCOCORTICOID RECEPTOR (RXFP1-GR) 轴
Thomas Dschietzig,Cornelia Bartsch,Gert Baumann et al.
Thomas Dschietzig et al.
The relaxin peptide family regulates diverse biological functions (central nervous processes, reproduction, cardiovascular and kidney function, and connective tissue composition) through different G protein-coupled receptors. We reported ea...
Characterization of the insulinostatic effect of urotensin II: a study in the perfused rat pancreas [0.03%]
尿鸟苷的胰岛素静止作用的特征研究：实验于灌流大鼠胰腺中进行
Ramona A Silvestre,Eva M Egido,Raquel Hernández et al.
Ramona A Silvestre et al.
We have investigated the effect of urotensin II (UII) on insulin secretion at normal and high glucose concentrations as well as induced by secretagogues acting on the B cell via different mechanisms. The study was performed in the perfused ...
Short-chain fatty acid signaling pathways in bovine mammary epithelial cells [0.03%]
短链脂肪酸在牛乳腺上皮细胞中的信号通路研究进展
Tomo Yonezawa,Satoshi Haga,Yosuke Kobayashi et al.
Tomo Yonezawa et al.
GPR41 and 43 have recently been identified as G-protein-coupled cell-surface receptors for short-chain fatty acids (SCFAs). Bovine orthologs of GPR41 and 43 (bGPR41 and 43) mRNA were detected by RT-PCR in cloned bovine mammary epithelial ce...