Endogenous ghrelin is an orexigenic peptide acting in the arcuate nucleus in response to fasting [0.03%]
内源性胃抑素是一种在下丘脑弓状核应答禁食的摄食刺激多肽
Michela Bagnasco,Giovanni Tulipano,Maria R Melis et al.
Michela Bagnasco et al.
Ghrelin, a circulating growth-hormone releasing peptide derived from stomach, stimulates food intake through neuropeptide Y (NPY) neurons of the arcuate nucleus in the hypothalamus (ARC). We examined the effect of ghrelin microinjected into...
Xenin plasma concentrations during modified sham feeding and during meals of different composition demonstrated by radioimmunoassay and chromatography [0.03%]
改变化学法和放射免疫法测定不同组成体形试验餐及假饲时血浆中支链氨基酸的浓度
Gerhard E Feurle,Sotirios Ikonomu,Giorgios Partoulas et al.
Gerhard E Feurle et al.
Xenin is a 25 amino acid peptide produced by specific endocrine cells of the duodenal mucosa. Xenin has multiple biological actions in the gastrointestinal tract. It modulates intestinal motility, affects exocrine pancreatic secretion, and ...
Triple therapy with octreotide, galanin, and serotonin reduces the size and blood vessel density and increases apoptosis of a rat colon carcinoma [0.03%]
生长抑素、加兰肽和五羟色胺三联疗法可抑制大鼠结肠癌的生长并增加肿瘤细胞凋亡比例
Magdy El-Salhy,Basel Sitohy,Orjan Norrgård
Magdy El-Salhy
A rat colonic adenocarcinoma was implanted subcutaneously in female nude (C57BL/6JBom-nu) mice. After 7 days, the animals were divided into different groups. One group received triple therapy with octreotide, galanin, and serotonin, 10 micr...
Different role of intracellular loops of glucagon-like peptide-1 receptor in G-protein coupling [0.03%]
胰高血糖素样肽-1受体不同胞内环对G蛋白偶联的调节作用不同
Aljosa Bavec,Mattias Hällbrink,Ulo Langel et al.
Aljosa Bavec et al.
Previous studies revealed the importance of the third intracellular loop of glucagon-like peptide-1 receptor (GLP-1R) in coupling to G(s) and G(i1) proteins. In order to further study the signaling mechanisms of GLP-1R, we tested three pept...
Early regulation of hypothalamic arcuate nucleus CART gene expression by short photoperiod in the Siberian hamster [0.03%]
西伯利亚仓鼠下丘脑弓状核CART基因表达的短日照诱导效应
Julian G Mercer,Claire Ellis,Kim M Moar et al.
Julian G Mercer et al.
Cocaine- and amphetamine-regulated transcript (CART) mRNA is expressed in a number of hypothalamic nuclei including the arcuate nucleus (ARC). An increase in CART gene expression in the ARC of juvenile female Siberian hamsters (Phodopus sun...
Existence of ghrelin-immunopositive and -expressing cells in the proventriculus of the hatching and adult chicken [0.03%]
刚出壳和成年鸡 Crop 中胃饥饿素免疫反应阳性细胞和表达细胞的存在
Reiko Wada,Ichiro Sakata,Hiroyuki Kaiya et al.
Reiko Wada et al.
Ghrelin was isolated from the rat stomach as an endogenous ligand for the growth hormone secretagogue receptor (GHS-R) and has been found in the gastrointestinal tract of many vertebrates. Although the sequence and structure of chicken ghre...
Intracisternal administration of Angiotensin II AT1 receptor antisense oligodeoxynucleotides protects against cerebral ischemia in spontaneously hypertensive rats [0.03%]
血管紧张素ⅡAT1受体反义寡核苷酸脑室内注射对 SHR 瘀血中风的防治作用研究
Haruki Yamakawa,M Ian Phillips,Juan M Saavedra
Haruki Yamakawa
Pharmacological blockade of peripheral and brain Angiotensin II (Ang II) AT(1) receptors protects against brain ischemia. To clarify the protective role of brain AT(1) receptors, we examined the effects of specific antisense oligodeoxynucle...
Proteolytic processing of chromogranin A by the prohormone convertase PC2 [0.03%]
由嗜铬颗粒A蛋白酶PC2对嗜铬颗粒A的蛋白水解过程
Alfred Doblinger,Alexandra Becker,Nabil G Seidah et al.
Alfred Doblinger et al.
The neuroendocrine secretory protein chromogranin A (CgA) is a precursor for various biologically active peptides. Several single and paired basic residues are present within its primary amino acid sequence comprising cleavage sites for pro...
Jean Morisset,Jean Lainé,Judith Bourassa et al.
Jean Morisset et al.
This study was undertaken to confirm the presence of CCK receptor subtypes in calf pancreas and establish their cellular localization. Using specific antibodies against CCKA and CCKB receptors, somatostatin, glucagon and insulin, we were ab...
The effect of endomorphins on the release of 3H-norepinephrine from rat nucleus tractus solitarii slices [0.03%]
内吗啡肽对切片延髓孤束核释放3H-去甲肾上腺素的影响
Mahmoud Al-Khrasani,Guy Elor,Mamode Yusuf Abbas et al.
Mahmoud Al-Khrasani et al.
We used two, 3-min field stimulation cycles 30 min apart (S1, S2) in 3H-norepinephrine-loaded, superfused rat nucleus tractus solitarii-dorsal motor vagal nucleus (NTS-DVN) slices. The stimulation-induced release was expressed as the area a...