Ameliorative effects of lotus seedpod proanthocyanidins on cognitive deficits and oxidative damage in senescence-accelerated mice [0.03%]
Yushi Gong,Liegang Liu,Bijun Xie et al.
Yushi Gong et al.
We investigated the effects of lotus seedpod proanthocyanidins (LSPC) administration by oral gavage for 3 months on body weight, learning and memory deficits using Y-maze test, oxidative stress and antioxidative enzyme activity in brain and...
Is co-administration of bupropion with SSRIs and SNRIs in forced swimming test in mice, predictive of efficacy in resistant depression? [0.03%]
Corina Prica,Martine Hascoet,Michel Bourin
Corina Prica
The monoamine hypothesis based on the deficiency of one or several monoamines is commonly evoked to explain the physiopathology of depression. This hypothesis initially based on noradrenalin and serotonin deficiency has been extended to dop...
Age related differences in stress-induced neurobehavioral responses in rats: modulation by antioxidants and nitrergic agents [0.03%]
Ayanabha Chakraborti,Kavita Gulati,Arunabha Ray
Ayanabha Chakraborti
The effect of restraint stress (RS) on neurobehavioral and brain oxidative/nitrosative stress markers and their modulation by antioxidants and nitrergic agents were evaluated in young (2 months) and old (16 months) male Wistar rats. Exposur...
Food deprivation-like effects of neuropeptide Y on heroin self-administration and reinstatement of heroin seeking in rats [0.03%]
Tia Maric,Stephanie Tobin,Tammie Quinn et al.
Tia Maric et al.
Numerous findings suggest that drug seeking and ingestive behaviors share common neurobiological mechanisms, but the relevant pathways are unknown. Dietary manipulations result in changes in endocrine the and/or neuropeptide signals, such a...
Eun Ran Kim,Arnold Leckstrom,Tooru M Mizuno
Eun Ran Kim
Neurotensin plays a role in regulating feeding behavior. Central injection of neurotensin reduces food intake and the anorectic effect of neurotensin is mediated through neurotensin receptor 1 (Ntsr1). Ntsr1-deficient mice are characterized...
Cabergoline and pramipexole fail to modify already established dyskinesias in an animal model of parkinsonism [0.03%]
Celia Larramendy,Irene R E Taravini,Mariano D Saborido et al.
Celia Larramendy et al.
Levodopa-induced dyskinesias are one of the major limiting side effects encountered in the treatment of Parkinson's disease. Dopamine agonists of the D2 family are less prone to induce these abnormal involuntary movements (AIMs), and in som...
A delayed and chronic treatment regimen with the 5-HT1A receptor agonist 8-OH-DPAT after cortical impact injury facilitates motor recovery and acquisition of spatial learning [0.03%]
Jeffrey P Cheng,Ann N Hoffman,Ross D Zafonte et al.
Jeffrey P Cheng et al.
An early (i.e., 15min) single systemic administration of the 5-HT(1A) receptor agonist 8-OH-DPAT enhances behavioral recovery after experimental traumatic brain injury (TBI). However, acute administration of pharmacotherapies after TBI may ...
Site-specific effects of anosmia and cloacal gland anesthesia on Fos expression induced in male quail brain by sexual behavior [0.03%]
Mélanie Taziaux,Matthieu Keller,Gregory F Ball et al.
Mélanie Taziaux et al.
In rats, expression of the immediate early gene, c-fos observed in the brain following male copulatory behavior relates mostly to the detection of olfactory information originating from the female and to somatosensory feedback from the peni...
Neonatal endotoxin exposure impairs avoidance learning and attenuates endotoxin-induced sickness behavior and central IL-1beta gene transcription in adulthood [0.03%]
Rachel A Kohman,Andrew J Tarr,Nathan L Sparkman et al.
Rachel A Kohman et al.
Infection during infancy, a time of critical neural development, may have long-term implications. Infection or exposure to an immune stimulus such as lipopolysaccharide (LPS) early in life leads to alterations in the reactivity of the hypot...
Chronic corticosterone administration does not potentiate unconditioned freezing to the predator odor, trimethylthiazoline [0.03%]
Jeffrey B Rosen,Melanie P Donley,Dione Gray et al.
Jeffrey B Rosen et al.
Chronic high levels of corticosterone (CORT) are known to facilitate learning and memory of aversive events. Whether this effect of chronic CORT also generalizes to unconditioned or unlearned fear behavior is not known. The present study in...