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Behavioural brain research. 2008 Dec 1;194(1):25-31. doi: 10.1016/j.bbr.2008.06.018 Q22.32025

Neonatal endotoxin exposure impairs avoidance learning and attenuates endotoxin-induced sickness behavior and central IL-1beta gene transcription in adulthood

新生期内毒素暴露可削弱避开学习并降低成年后内毒素诱发的病态行为和中枢IL-1β基因转录水平 翻译改进

Rachel A Kohman  1, Andrew J Tarr, Nathan L Sparkman, Tiroyaone M H Bogale, Gary W Boehm

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  • 1 Department of Psychology, Texas Christian University, Fort Worth, TX 76129 USA.
  • DOI: 10.1016/j.bbr.2008.06.018 PMID: 18634831

    摘要 Ai翻译

    Infection during infancy, a time of critical neural development, may have long-term implications. Infection or exposure to an immune stimulus such as lipopolysaccharide (LPS) early in life leads to alterations in the reactivity of the hypothalamic-pituitary-adrenal axis (HPA) and febrile response in adulthood. Relatively few studies have assessed the behavioral and cognitive alterations induced by perinatal immune challenge. The data indicate that neonatal... ...点击完成人机验证后继续浏览
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    期刊名:Behavioural brain research

    缩写:BEHAV BRAIN RES

    ISSN:0166-4328

    e-ISSN:1872-7549

    IF/分区:2.3/Q2

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    Neonatal endotoxin exposure impairs avoidance learning and attenuates endotoxin-induced sickness behavior and central IL-1beta gene transcription in adulthood