Interplay between glutamate and serotonin within the dorsal periaqueductal gray modulates anxiety-related behavior of rats exposed to the elevated plus-maze [0.03%]
Cladis L K Moraes,Leandro J Bertoglio,Antonio P Carobrez
Cladis L K Moraes
Several neurotransmitters, including glutamate and serotonin, modulate defensive behaviors related to anxiety in the rat dorsal periaqueductal gray (PAG). Although both glutamate N-methyl-d-aspartic acid (NMDA) and serotonin type 1-A (5-HT(...
A role of nitric oxide mechanism involved in the protective effects of venlafaxine in sleep deprivation [0.03%]
Anil Kumar,Ruchika Garg
Anil Kumar
The present study was designed to explore the possible nitric oxide mechanism in protective effect of venlafaxine in sleep deprivation in mice. Laca mice were sleep deprived for period of 72 h using grid suspended over water method. Venlafa...
Non-linear quantitative electroencephalographic (qEEG) changes during processing of chemo-sensory stimulations: a preliminary study [0.03%]
Anett Járdánházy,Tamás Járdánházy
Anett Járdánházy
The present study was to investigate the processing of pleasant smell and taste stimuli by non-linear EEG measures. Point correlation dimension (PD2i) has been used for studying the local, and synchronization likelihood (SL) the global dyna...
The combination of human neuronal serotonergic cell implants and environmental enrichment after contusive SCI improves motor recovery over each individual strategy [0.03%]
Mary J Eaton,Damien D Pearse,Jordan S McBroom et al.
Mary J Eaton et al.
A human neuronal cell line, hNT2.19, which secretes serotonin (5-HT) after differentiation, was used as a transplant source to improve motor dysfunction following severe contusive spinal cord injury (SCI). Also, environmental enrichment (EE...
A novel adenosine A(1) and A(2A) receptor antagonist ASP5854 ameliorates motor impairment in MPTP-treated marmosets: comparison with existing anti-Parkinson's disease drugs [0.03%]
Takuma Mihara,Akinori Iwashita,Nobuya Matsuoka
Takuma Mihara
Recent evidence indicates that adenosine A(2A) receptor antagonists hold therapeutic potential for the treatment of Parkinson's disease (PD). A study on the novel adenosine A(1) and A(2A) receptor dual antagonist 5-[5-amino-3-(4-fluoropheny...
Comparative Study
Behavioural brain research. 2008 Dec 12;194(2):152-61. DOI:10.1016/j.bbr.2008.06.035 2008
The hyperactive syndrome: metanalysis of genetic alterations, pharmacological treatments and brain lesions which increase locomotor activity [0.03%]
Davide Viggiano
Davide Viggiano
The large number of transgenic mice realized thus far with different purposes allows addressing new questions, such as which animals, over the entire set of transgenic animals, show a specific behavioural abnormality. In the present study, ...
M Cecchi,N Capriles,S J Watson et al.
M Cecchi et al.
We compared acute and chronic antinociceptive effects of morphine in animals with high reactivity (HR) vs. low reactivity (LR) to novelty. Antinociception was assessed by tail-flick test. Rats were i.p. injected with either saline or morphi...
Lipopolysaccharide-induced immune activation impairs attention but has little effect on short-term working memory [0.03%]
John Michael Holden,Julia E Meyers-Manor,J Bruce Overmier et al.
John Michael Holden et al.
Cytokine-induced CNS inflammation has been theorized to contribute to cognitive dysfunction in sickness and neurodegenerative disease. We investigated the effects of systemic endotoxin-induced acute immune activation and inflammation on wor...
Antidepressant-like effect of liquiritin from Glycyrrhiza uralensis in chronic variable stress induced depression model rats [0.03%]
Zhiyu Zhao,Weixing Wang,Hongzhu Guo et al.
Zhiyu Zhao et al.
Many flavonoids extracted from nature plants have been reported to exert antidepressant-like effect in animal studies. The present study was designed to observe the effects of liquiritin, a flavone compound derived from Glycyrrhiza uralensi...
Temporal patterns of motor behavioural improvements by MK-801 in Mongolian gerbils submitted to different duration of global cerebral ischemia [0.03%]
Branka Janać,Vesna Selaković,Lidija Radenović
Branka Janać
The purpose of this study was to investigate the temporal pattern of NMDA receptors antagonist-MK-801 on motor behaviour parameters in gerbils submitted to different duration of global cerebral ischemia. The common carotid arteries of gerbi...