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Comparative Study Behavioural brain research. 2008 Dec 12;194(2):152-61. doi: 10.1016/j.bbr.2008.06.035 Q22.32025

A novel adenosine A(1) and A(2A) receptor antagonist ASP5854 ameliorates motor impairment in MPTP-treated marmosets: comparison with existing anti-Parkinson's disease drugs

一种新型腺苷A1和A2A受体拮抗剂ASP5854可改善MPTP致狨猴的运动障碍:与现有抗帕金森病药物比较研究 翻译改进

Takuma Mihara  1, Akinori Iwashita, Nobuya Matsuoka

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  • 1 Department of Neuroscience, Pharmacology Research Labs, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan. takuma.mihara@jp.astellas.com
  • DOI: 10.1016/j.bbr.2008.06.035 PMID: 18657577

    摘要 Ai翻译

    Recent evidence indicates that adenosine A(2A) receptor antagonists hold therapeutic potential for the treatment of Parkinson's disease (PD). A study on the novel adenosine A(1) and A(2A) receptor dual antagonist 5-[5-amino-3-(4-fluorophenyl)pyrazin-2-yl]-1-isopropylpyridine-2(1H)-one (ASP5854) showed it to be effective in various rodents models of PD and cognition. In the present study, we further investigated the potential of ASP5854 as an anti-PD drug u... ...点击完成人机验证后继续浏览
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    期刊名:Behavioural brain research

    缩写:BEHAV BRAIN RES

    ISSN:0166-4328

    e-ISSN:1872-7549

    IF/分区:2.3/Q2

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    A novel adenosine A(1) and A(2A) receptor antagonist ASP5854 ameliorates motor impairment in MPTP-treated marmosets: comparison with existing anti-Parkinson's disease drugs