Single Cell mass spectrometry: Towards quantification of small molecules in individual cells [0.03%]
单细胞质谱：面向单个细胞中小分子定量的表面增强激光解吸电离质谱技术
Yunpeng Lan,Zhu Zou,Zhibo Yang
Yunpeng Lan
Studying cell heterogeneity can provide a deeper understanding of biological activities, but appropriate studies cannot be performed using traditional bulk analysis methods. The development of diverse single cell bioanalysis methods is in u...
Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization [0.03%]
多加合物组学：推进质谱技术以全面表征暴露组
Mu-Rong Chao,Yuan-Jhe Chang,Marcus S Cooke et al.
Mu-Rong Chao et al.
Adductomics, an emerging field within the 'omics sciences, focuses on the formation and prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous agents in biological systems. These modifications often result from expo...
Jinhua Chi,Jingmin Shu,Ming Li et al.
Jinhua Chi et al.
Metabolomics and artificial intelligence (AI) form a synergistic partnership. Metabolomics generates large datasets comprising hundreds to thousands of metabolites with complex relationships. AI, aiming to mimic human intelligence through c...
Nanopore Single-molecule Analysis of Biomarkers: Providing Possible Clues to Disease Diagnosis [0.03%]
纳米孔单分子生物标志物分析或可为疾病诊断提供线索
Xiaohan Chen,Shuo Zhou,Yunjiao Wang et al.
Xiaohan Chen et al.
Biomarker detection has attracted increasing interest in recent years due to the minimally or non-invasive sampling process. Single entity analysis of biomarkers is expected to provide real-time and accurate biological information for early...
Advances in Imaging Mass Spectrometry for Biomedical and Clinical Research [0.03%]
用于生物医学和临床研究的成像质谱技术进展
Katerina V Djambazova,Jacqueline M van Ardenne,Jeffrey M Spraggins
Katerina V Djambazova
Imaging mass spectrometry (IMS) allows for the untargeted mapping of biomolecules directly from tissue sections. This technology is increasingly integrated into biomedical and clinical research environments to supplement traditional microsc...
Microfluidic platforms integrated with nano-sensors for point-of-care bioanalysis [0.03%]
集成纳米传感器的微流控平台用于床边生物分析
Hamed Tavakoli,Samayeh Mohammadi,Xiaochun Li et al.
Hamed Tavakoli et al.
Microfluidic technology provides a portable, cost-effective, and versatile tool for point-of-care (POC) bioanalysis because of its associated advantages such as fast analysis, low volumes of reagent consumption, and high portability. Along ...
Probing the dynamic crosstalk of lysosomes and mitochondria with structured illumination microscopy [0.03%]
利用结构照明显微镜探测溶酶体和线粒体的动态串扰现象
Xiuqiong Xu,Kangqiang Qiu,Zhiqi Tian et al.
Xiuqiong Xu et al.
Structured illumination microscopy (SIM) is a super-resolution technology for imaging living cells and has been used for studying the dynamics of lysosomes and mitochondria. Recently, new probes and analyzing methods have been developed for...
Sensorization of microfluidic brain-on-a-chip devices: Towards a new generation of integrated drug screening systems [0.03%]
微流控器官芯片中的传感器集成：迈向新一代的药物筛选系统
Attilio Marino,Matteo Battaglini,Marie Celine Lefevre et al.
Attilio Marino et al.
Brain-on-a-chip (BoC) devices show typical characteristics of brain complexity, including the presence of different cell types, separation in different compartments, tissue-like three-dimensionality, and inclusion of the extracellular matri...
Hanjun Cheng,Yin Tang,Zhonghan Li et al.
Hanjun Cheng et al.
Metabolic assays serve as pivotal tools in biomedical research, offering keen insights into cellular physiological and pathological states. While mass spectrometry (MS)-based metabolomics remains the gold standard for comprehensive, multipl...
CRISPR-based Biosensors for Human Health: A Novel Strategy to Detect Emerging Infectious Diseases [0.03%]
基于CRISPR的生物传感器在人类健康领域的新应用：检测新发传染病的一种新型策略
Yawen He,Qinqin Hu,Samantha San et al.
Yawen He et al.
Infectious diseases (such as sepsis, influenza, and malaria), caused by various pathogenic bacteria and viruses, are widespread across the world. Early and rapid detection of disease-related pathogens is necessary to reduce their spread in ...