Masoud Negahdary,Vaibhav Thirumalai,Mohamed S Draz
Masoud Negahdary
The effective management of epilepsy requires analytical tools capable of addressing the lack of specific biomarkers, and current antiepileptic drugs (AEDs) suffer from response variability, a narrow therapeutic index, and unpredictable neu...
Ambient high-spatial-resolution mass spectrometry imaging: recent advances in technologies and metabolomics studies [0.03%]
环境高空间分辨率质谱成像技术的最新进展及代谢组学研究
Dan Chen,Nathan Colwell,Zhibo Yang
Dan Chen
Achieving high-spatial-resolution in ambient mass spectrometry imaging (MSI) is critical in accurately characterizing the spatial distribution of biomolecules. Ambient MSI enables in situ mapping spatial heterogeneity of metabolites under a...
Current smartphone-assisted point-of-care cancer detection: Towards supporting personalized cancer monitoring [0.03%]
当前的智能手机辅助癌症现场检测：迈向个性化癌症监测支持体系
Linh Thi Phuong Le,Anh Hoang Quan Nguyen,Le Minh Tu Phan et al.
Linh Thi Phuong Le et al.
With the rising incidence of cancer-related mortality, new enabling technologies are necessary to offer comprehensive molecular profiles of patients in order to assist clinicians to establish an early presumptive diagnosis. Biosensors that ...
Stable isotope ratio analysis: an emerging tool to trace the origin of falsified medicines [0.03%]
稳定同位素比分析：一种追踪假冒药品来源的新工具
Alberto Roncone,Simon D Kelly,Zoe Giannioti et al.
Alberto Roncone et al.
Falsified medicines pose a serious threat to global public health. Over the past few decades, the number of public health issues and seizures of falsified medicines has dramatically increased across the world. The development of new analyti...
Multifunctional Nanobody Fusion Proteins in Immunoassays: Diverse Strategies for Enhanced Analytical Performance [0.03%]
免疫分析中的纳米抗体融合蛋白：提高分析性能的多种策略
Qiyi He,Junkang Pan,Yijia Zhang et al.
Qiyi He et al.
Nanobodies, derived from camelid heavy-chain antibodies, offer exceptional specificity, stability, and solubility, enabling rapid and sensitive immunoassays. Their small size makes them ideal scaffolds for genetic fusion with reporter prote...
Nanoplasmonics biosensors: At the frontiers of biomedical diagnostics [0.03%]
纳米等离激元生物传感器：生物医药诊断的前沿技术
Aidan J Canning,Joy Q Li,Supriya Atta et al.
Aidan J Canning et al.
This article presents an overview of various nanoplasmonics biosensors and their diverse applications, focusing on recent developments in our laboratory. We describe the versatility and effectiveness of different plasmonics-active platforms...
Mass Spectrometry-based Single-Cell Lipidomics: Advancements, Challenges, and the Path Forward [0.03%]
基于质谱的单细胞脂质组学：进展、挑战及未来方向
Caitlin E Randolph,Palak Manchanda,Harshit Arora et al.
Caitlin E Randolph et al.
In the past decade, lipidomics, now recognized as standalone subdiscipline of metabolomics, has gained considerable attention. Due to its sensitivity and unparalleled versatility, mass spectrometry (MS) has emerged as the tool of choice for...
Robert Powers,Erik R Andersson,Amanda L Bayless et al.
Robert Powers et al.
A literature survey was conducted to identify current practices used by NMR metabolomics investigators when conducting and reporting their metabolomics studies. A total of 463 papers from 2020 and 80 papers from 2010 were selected from PubM...
Darcy Cochran,Mai NourEldein,Dominika Bezdekova et al.
Darcy Cochran et al.
Cancer is a leading cause of world-wide death and a major subject of clinical studies focused on the identification of new diagnostic tools. An in-depth meta-analysis of 244 clinical metabolomics studies of human serum samples highlights a ...
Frontiers in Mass Spectrometry-Based Spatial Metabolomics: Current Applications and Challenges in the Context of Biomedical Research [0.03%]
基于质谱的空间代谢组学前沿：生物医学研究中的当前应用与挑战
Kate Wheeler,Camil Gosmanov,Michael Jimenez Sandoval et al.
Kate Wheeler et al.
Metabolites are critical products and mediators of cellular and tissue function, and key signals in cell-to-cell, organ-to-organ and cross-organism communication. Many of these interactions are spatially segregated. Thus, spatial metabolomi...