Mouse liver plasma membrane redox system activity is altered by aging and modulated by calorie restriction [0.03%]
热量限制可改变老龄小鼠肝血浆膜抗氧化体系的活性
G López-Lluch,M Rios,M A Lane et al.
G López-Lluch et al.
Caloric restriction (CR) is known as the only non-genetic method proven to slow the rate of aging and extend lifespan in animals. Free radicals production emerges from normal metabolic activity and generates the accumulation of oxidized mac...
Frederick L Crane,Hans Low
Frederick L Crane
We consider possible contributions of plasma membrane redox systems to Aging control by sirtuin (SIR). Reported changes in plasma membrane redox introduced by calorie restriction (CR) may lead to activation of SIR. The most obvious effect w...
Plácido Navas,José Manuel Villalba,Giorgio Lenaz
Plácido Navas
Coenzyme Q (Q) is reduced in plasma membrane and mitochondria by NAD(P)H-dependent reductases providing reducing equivalents to maintain both respiratory chain and antioxidant protection. Reactive oxygen species (ROS) are accumulated in the...
The plasma membrane redox system: a candidate source of aging-related oxidative stress [0.03%]
质膜氧化还原体系：与衰老相关氧化应激的候选来源
Aubrey D N J de Grey
Aubrey D N J de Grey
The plasma membrane redox system (PMRS) is an electron transport chain in the plasma membrane that transfers electrons from either intra- or extracellular donors to extracellular acceptors. Unlike the superoxide-generating NADPH oxidase of ...
Guest editorial [0.03%]
客座编辑絮语
Rafael C de Cabo,Plácido Navas
Rafael C de Cabo
Exercise training effects on skeletal muscle plasticity and IGF-1 receptors in frail elders [0.03%]
运动训练对脆弱老年人骨骼肌可塑性及IGF-1受体的影响
Maria L Urso,Maria A Fiatarone Singh,Wenjing Ding et al.
Maria L Urso et al.
Age-related sarcopenia inhibits mobility, increasing the risk for developing many diseases, including diabetes, arthritis, osteoporosis, and heart disease. Tissue plasticity, or the ability to regenerate following stress, has been a subject...
Decreased alpha-adrenergic constriction of renal preglomerular arteries occurs with age and is gender-specific in the rat [0.03%]
大鼠肾血管的α-肾上腺素能收缩功能随年龄增长而下降且与性别有关
Jeff C Falcone,Irving G Joshua,John C Passmore
Jeff C Falcone
Age and/or gender appear to moderate alpha-adrenergic mediated constrictor mechanisms found in the interlobar arteries of the Munich Wistar rat. We have determined the extent of constriction to alpha-adrenergic receptor stimulation using no...
Development of an in vitro model of excess intracellular reactive oxygen species [0.03%]
体内多余细胞内活性氧模型的开发
K A Greer,M Pine,D L Busbee
K A Greer
These investigations characterize an in vitro model for generating excess intracellular reactive oxygen species (ROS). This novel model may be useful in the identification and delineation of cellular mechanisms associated with aging due to ...
Phenotype screening for genetically determined age-onset disorders and increased longevity in ENU-mutagenized mice [0.03%]
ENU诱导的突变小鼠的遗传性老年发病疾病和延长寿命的表型筛选
Dabney K Johnson,Eugene M Rinchik,Naima Moustaid-Moussa et al.
Dabney K Johnson et al.
With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the chemical N-ethyl-N...
Effect of diet on the disruption of operant responding at different ages following exposure to (56)Fe particles [0.03%]
饮食对不同年龄段暴露于铁粒子后的操作反应干扰的影响
Bernard M Rabin,Kirsty L Carrihill-Knoll,Amanda Carey et al.
Bernard M Rabin et al.
Rats were exposed to 2.0 Gy of (56)Fe particles to study the relationship between age and diet in the heavy particle-induced disruption of performance on an ascending fixed-ratio task. Irradiation produced a disruption of operant responding...