Erectile dysfunction is associated with low bioactive testosterone levels and visceral adiposity in men with type 2 diabetes [0.03%]
2型糖尿病男性患者的勃起功能障碍与生物活性睾酮水平低下和内脏脂肪蓄积有关
D Kapoor,S Clarke,K S Channer et al.
D Kapoor et al.
Low testosterone levels in men are associated with type 2 diabetes mellitus. Erectile dysfunction (ED) is a frequent complication of type 2 diabetes. The aim of our cross-sectional study was to investigate the relationship between ED and to...
Environmental, occupational and familial risks for testicular cancer: a hospital-based case-control study [0.03%]
基于医院的睾丸癌病例对照研究中的环境、职业和家庭风险因素分析
Marie Walschaerts,Audrey Muller,Jacques Auger et al.
Marie Walschaerts et al.
Testicular cancer (TC) risk factors remain largely unknown, except for personal history of cryptorchidism and familial history of TC. We conducted a hospital-based case-control study on familial, environmental and occupational conditions in...
Trends in testicular germ cell tumours by ethnic group in the United States [0.03%]
美国按种族分睾丸生殖细胞肿瘤的流行趋势
Mona N Shah,Susan S Devesa,Kangmin Zhu et al.
Mona N Shah et al.
The incidence of testicular germ cell tumours (TGCT) has increased in white and black men in the United States. Little is known, however, about trends among men of other racial/ethnic groups. The current study sought to examine TGCT pattern...
Inge A Olesen,Christina E Hoei-Hansen,Niels E Skakkebaek et al.
Inge A Olesen et al.
Carcinoma in situ (CIS) testis is the precursor stage for the majority of testicular germ cell tumours (TGCT). Infertility is one of the conditions known to predispose to TGCT, but based on scarce existing data, the prevalence of CIS in thi...
Christina E Hoei-Hansen,Inge A Olesen,Niels Jorgensen et al.
Christina E Hoei-Hansen et al.
Testicular germ cell tumours have a favourable prognosis if detected early, but are potentially lethal in a subset of patients. Multi-modality treatment is often necessary, thus the preferable time of diagnosis is at the pre-invasive, but u...
Michael K Skinner
Michael K Skinner
The ability of an environmental exposure (i.e. endocrine disruptor) during sex determination to reprogramme the male germline and promote an epigenetic transgenerational disease phenotype suggests that environmental factors and compounds ma...
The transforming growth factor-beta superfamily in early spermatogenesis: potential relevance to testicular dysgenesis [0.03%]
转化生长因子-β超家族在早期精子发生中的作用及与睾丸发育异常的相关性
K L Loveland,V Dias,S Meachem et al.
K L Loveland et al.
Regulated transforming growth factor-beta (TGFbeta) superfamily signalling is an integral part of normal testicular development and the processes that enable the production of fertile sperm. Through shared utilization of receptors, signal t...
Inhibition of tyrosine kinases PDGFR and C-Kit by imatinib mesylate interferes with postnatal testicular development in the rat [0.03%]
甲磺酸伊马替尼通过抑制血小板源性生长因子受体和C-Kit干扰大鼠产后睾丸发育
Mirja Nurmio,Jorma Toppari,Farasat Zaman et al.
Mirja Nurmio et al.
The tyrosine kinase receptor c-kit and its interaction with the ligand, stem cell factor (SCF), play an essential role in the developing testis. C-kit is important for the development of the Leydig cells and for the migration, proliferation...
Jeroen de Jong,Hans Stoop,Ad J M Gillis et al.
Jeroen de Jong et al.
The JKT-1 cell line has been used in multiple independent studies as a representative model of human testicular seminoma. However, no cell line for this specific tumour type has been independently confirmed previously; and therefore, the se...
Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives [0.03%]
人类外生殖细胞肿瘤为何多发于身体正中线：旧概念与新视角
J Wolter Oosterhuis,Hans Stoop,Friedemann Honecker et al.
J Wolter Oosterhuis et al.
Hypotheses on the origin and distribution of extragonadal germ cell tumours (GCTs) and teratomas are briefly reviewed and revisited in the light of (i) new developments in the classification of GCTs, (ii) data on genomic imprinting of these...